The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression
Open accessAbstract
Yeast cells modulate their protein synthesis capacity in response to physiological needs through the transcriptional control of ribosomal protein (RP) genes. Here we demonstrate that the transcription factor Sfp1, previously shown to play a role in the control of cell size, regulates RP gene expression in response to nutrients and stress. Under optimal growth conditions, Sfp1 is localized to the nucleus, bound to the promoters of RP genes, and helps promote RP gene expression. In response to inhibition of target of rapamycin (TOR) signaling, stress, or changes in nutrient availability, Sfp1 is released from RP gene promoters and leaves the nucleus, and RP gene transcription is down-regulated. Additionally, cells lacking Sfp1 fail to appropriately modulate RP gene expression in response to environmental cues. We conclude that Sfp1 integrates information from nutrient- and stress-responsive signaling pathways to help control RP gene expression.
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Cited by
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Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence
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“Furthermore, Sfp1, the transcriptional activator that controls ribosome biogenesis (Jorgensen et al., 2004; Marion et al., 2004), is found in the cytoplasm in large cells, unable to promote expression of ribosome biogenesis genes (Figures S6B and S6C).”
BackgroundReiling, J. H., & Sabatini, D. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209889 · Cited by 311
(2006) · doi:10.1007/978-3-540-28398-0 · Cited by 303
Kemmeren, P., Sameith, K., van de Pasch, L. A. L., Benschop, J. J., Lenstra, T. L., Margaritis, T., O’Duibhir, E., Apweiler, E., van Wageningen, S., Ko, C. W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.02.054 · Cited by 277
Metadata
- Authors
- Marion, R. M., Regev, A., Segal, E., Barash, Y., Koller, D., Friedman, N., & O'Shea, E. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-09-07
- Volume
- 101
- Issue
- 40
- Pages
- 14315-14322
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1975471112
- Cited by
- 386
- References
- 48
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- green
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