The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals
Open accessAbstract
We recently found that long-term exposure to nitric oxide (NO) triggers mitochondrial biogenesis in mammalian cells and tissues by activation of guanylate cyclase and generation of cGMP. Here, we report that the NO/cGMP-dependent mitochondrial biogenesis is associated with enhanced coupled respiration and content of ATP in U937, L6, and PC12 cells. The observed increase in ATP content depended entirely on oxidative phosphorylation, because ATP formation by glycolysis was unchanged. Brain, kidney, liver, heart, and gastrocnemius muscle from endothelial NO synthase null mutant mice displayed markedly reduced mitochondrial content associated with significantly lower oxygen consumption and ATP content. In these tissues, ultrastructural analyses revealed significantly smaller mitochondria. Furthermore, a significant reduction in the number of mitochondria was observed in the subsarcolemmal region of the gastrocnemius muscle. We conclude that NO/cGMP stimulates mitochondrial biogenesis, both in vitro and in vivo, and that this stimulation is associated with increased mitochondrial function, resulting in enhanced formation of ATP.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Chronic exposure to relatively high levels of NO results in mitochondrial biogenesis [113-115], which could reprogram a cell or tissue to have a higher metabolic capacity.”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [115]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Mitochondrial diseases in man and mouse
Wallace, D. C. (1999) · Science · doi:10.1126/science.283.5407.1482 · Cited by 3,060
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546
Red Cell Metabolism: A Manual of Biochemical Methods.
(1971) · Annals of Internal Medicine · doi:10.7326/0003-4819-75-6-985_1 · Cited by 2,327
Hypertension in mice lacking the gene for endothelial nitric oxide synthase
Huang, P. L., Huang, Z., Mashimo, H., Bloch, K. D., Moskowitz, M. A., Bevan, J. A., & Fishman, M. C. (1995) · Nature · doi:10.1038/377239a0 · Cited by 2,070
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952
Stuehr, D. J., & Nathan, C. F. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.5.1543 · Cited by 1,744
Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis
Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10268 · Cited by 1,285
Research works printed but not linked: 2
- Duguez, S., Feasson, L., Denis, C. & Freyssenet, D. (2002) Am. J. Physiol. 282, E802–E809.
- Nakane, M. (2003) Clin. Chem. Lab. Med. 41, 865–870.12940510
Cited by
Sorted by citations
Items 301–400 of 492
Caballano‐Infantes, E., Bautista, J., Beltrán-Povea, A., Cahuana, G. M., Soria, B., Hajji, N., Bedoya, F. J., & Tejedo, J. R. (2017) · World Journal of Stem Cells · doi:10.4252/wjsc.v9.i2.26 · Cited by 22
Suh, K. S., Chon, S., & Choi, E. M. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.10.001 · Cited by 24
Boon, M. R., Hanssen, M. J. W., Brans, B. T., Hülsman, C. J. M., Joris Hoeks, J., Nahon, K. J., Bakker, C., van Klinken, J. B., Havekes, B., Schaart, G., et al. (2018) · Diabetologia · doi:10.1007/s00125-018-4752-6 · Cited by 22
Akinrinde, A. S., Tijani, M. O., Awodele, O. A., & Oyagbemi, A. A. (2020) · Toxicology and Environmental Health Sciences · doi:10.1007/s13530-020-00070-6 · Cited by 22
Effects of nitric oxide on steroidogenesis and apoptosis in goat luteinized granulosa cells
Guo, Y., Zhang, G., Yao, X., Tong, R., Cheng, C.-Y., Zhang, T., Wang, S., Yang, H., & Wang, F. (2018) · Theriogenology · doi:10.1016/j.theriogenology.2018.12.007 · Cited by 21
l ‐Citrulline supplementation improves glucose and exercise tolerance in obese male mice
Eshreif, A., Batran, R. A., Jamieson, K. L., Darwesh, A. M., Gopal, K., Greenwell, A. A., Zlobine, I., Aburasayn, H., Eaton, F., Mulvihill, E. E., et al. (2019) · Experimental Physiology · doi:10.1113/ep088109 · Cited by 21
Nelissen, E., Argyrousi, E. K., van Goethem, N. P., Zhao, F., Hines, C. D. G., Swaminath, G., Gerisch, M., Hueser, J., Sandner, P., & Prickaerts, J. (2021) · Biomedicines · doi:10.3390/biomedicines9081047 · Cited by 21
Red blood cell ATP/ADP & nitric oxide: The best vasodilators in diabetic patients
Bakhtiari, N., Hosseinkhani, S., Larijani, B. A., Mohajeri‐Tehrani, M. R., & Fallah, A. (2012) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/2251-6581-11-9 · Cited by 21
Choi, E. M., Suh, K. S., Rhee, S. Y., & Kim, Y. S. (2014) · Free Radical Research · doi:10.3109/10715762.2014.903562 · Cited by 21
Stanley, J. L., Sulek, K., Andersson, I. J., Davidge, S. T., Kenny, L. C., Sibley, C. P., Mandal, R., Wishart, D. S., Broadhurst, D., & Baker, P. N. (2015) · Scientific Reports · doi:10.1038/srep18241 · Cited by 21
Ma, X., Xie, Y., Chen, Y., Han, B., Li, J., & Qi, S. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.08.026 · Cited by 20
Cytotoxicity and mitochondrial dysfunction caused by the dietary supplement l-norvaline
Samardzic, K., & Rodgers, K. J. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.01.020 · Cited by 20
Bolasco, P. (2020) · Nutrients · doi:10.3390/nu12061773 · Cited by 20
Moroz, L. L., & Kohn, A. B. (2007) · Advances in experimental biology · doi:10.1016/s1872-2423(07)01001-0 · Cited by 20
Wang, D., Wu, M., Li, S., Gao, Q., & Zeng, Q.-P. (2015) · Science China Life Sciences · doi:10.1007/s11427-014-4736-9 · Cited by 21
Cyclic stretch increases mitochondrial biogenesis in a cardiac cell line
Kim, H. K., Kang, Y. G., Jeong, S. H., Park, N., Marquez, J. C., Ko, K. S., Rhee, B. D., Shin, J., & Han, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.10.003 · Cited by 19
Zhang, Y., Wang, S., Zhou, Q., Hu, Y., Xie, Y., Fang, W., Yang, C., Wang, Z., Ye, S., Wang, X., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.320714 · Cited by 19
Can Colorectal Cancer be Prevented or Treated by Oral Hormone Replacement Therapy?
Li, P., Lin, J. E., Schulz, S., Pitari, G. M., & Waldman, S. A. (2009) · Current Molecular Pharmacology · doi:10.2174/1874-470210902030285 · Cited by 19
Sharma, M., Rana, U., Joshi, C., Michalkiewicz, T., Afolayan, A., Parchur, A., Joshi, A., Teng, R., & Konduri, G. G. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0434oc · Cited by 19
van der Stel, W., Yang, H., Vrijenhoek, N. G., Schimming, J. P., Callegaro, G., Carta, G., Darici, S., Delp, J., Forsby, A., White, A., et al. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03160-7 · Cited by 20
Joo, J. I., & Yun, J. W. (2011) · Cellular Physiology and Biochemistry · doi:10.1159/000327959 · Cited by 19
Becerril, S., Rodrı́guez, A., Catalán, V., Sáinź, N., Ramírez, B., Gómez‐Ambrosi, J., & Frühbeck, G. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00039.2012 · Cited by 18
Corum, D. G., Jenkins, D. P., Heslop, J. A., Tallent, L. M., Beeson, G. C., Barth, J. L., Schnellmann, R. G., & Muise‐Helmericks, R. C. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013716 · Cited by 18
Lopez-Bellón, S., Rodríguez-López, S., González-Reyes, J. A., Burón, M. I., de Cabo, R., & Villalba, J. M. (2022) · GeroScience · doi:10.1007/s11357-022-00574-8 · Cited by 19
Chen, T., Bai, D., Gong, C., Cao, Y. J., Yan, X., & Peng, R. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116556 · Cited by 18
The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric Oxide
BOVERIS, A., Carreras, M. C., & Poderoso, J. J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00013-7 · Cited by 19
Kalogeris, T. J., Baines, C. P., & Korthuis, R. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098459 · Cited by 18
Artificial Mitochondrial Nanorobots Deliver Energy In Vivo by Oral Administration
Li, N., Zhou, M., Wu, Z., Chen, Y., Duan, Y., Zhang, Z.-Q., Wu, Z., Xia, X., Shen, J., Mao, C., et al. (2025) · Advanced Materials · doi:10.1002/adma.202500495 · Cited by 17
Suh, K., Rhee, S., Kim, Y. S., & Choi, E. (2014) · Food & Function · doi:10.1039/c4fo00127c · Cited by 17
de Carvalho, M. A. J., Chaves-Filho, A. J. M., de Souza, A. G., Lima, C. N. D. C., de Lima, K. A., Vasconcelos, E. R. R., Feitosa, M. L., Oliveira, J. V. S., de Souza, D. A. A., Macêdo, D. S., et al. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.04.008 · Cited by 17
Arginase-2 mediates renal ischemia-reperfusion injury
Raup‐Konsavage, W. M., Gao, T., Cooper, T. K., Morris, S. M., Reeves, W. B., & Awad, A. S. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00620.2016 · Cited by 17
RetractedPennec, S. L., Mirebeau‐Prunier, D., Boutet-Bouzamondo, N., Jacques, C., Guillotin, D., Lauret, É., Houlgatte, R., Malthièry, Y., & Savagner, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.217521 · Cited by 16
Cho, S., Park, J., & Hwang, E. S. (2011) · Molecules and Cells · doi:10.1007/s10059-011-1032-4 · Cited by 16
Suwa, M., Nakano, H., Radak, Z. O., & Kumagai, S. (2015) · Europe PMC (PubMed Central) · Cited by 16
Sharma, N. S., Wallenstein, E. J., Novik, E., Maguire, T. J., Schloss, R. S., & Yarmush, M. L. (2009) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2008.0303 · Cited by 16
Choi, S., Yu, E., Kim, D., Sugimori, M., & Llinás, R. R. (2015) · Physiological Reports · doi:10.14814/phy2.12261 · Cited by 15
Priming metabolism with the type 5 phosphodiesterase: the role of cGMP-hydrolyzing enzymes
Campolo, F., Pofi, R., Venneri, M. A., & Isidori, A. M. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.08.007 · Cited by 16
PGC-1α Mediated Muscle Aerobic Adaptations to Exercise, Heat and Cold Exposure
Ihsan, M., Watson, G., & Abbiss, C. R. (2014) · Cellular and Molecular Exercise Physiology · doi:10.7457/cmep.v3i1.e7 · Cited by 15
Wright, N. J. D. (2019) · AIMS neuroscience · doi:10.3934/neuroscience.2019.3.146 · Cited by 15
Mitochondrial biogenesis of astrocytes is increased under experimental septic conditions
Wang, Y., Chen, Z., Zhang, Y., Fang, S., & Zeng, Q. (2014) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20131934 · Cited by 15
Zhang, H., Zheng, P., Chen, D., Yu, B., He, J., Mao, X., Yu, J., Luo, Y., Luo, J., Huang, Z., et al. (2021) · Antioxidants · doi:10.3390/antiox10121995 · Cited by 14
Bueno, M., Calyeca, J., Khaliullin, T. O., Miller, M. P., Álvarez, D., Rosas, L., Brands, J., Baker, C., Nasser, A., Shulkowski, S., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.161487 · Cited by 14
Turner, K., Kronemberger, A., Bae, D., Bock, J. M., Hughes, W. E., Ueda, K., Feider, A. J., Hanada, S., de Sousa, L. G. O., Harris, M. P., et al. (2022) · Nutrients · doi:10.3390/nu14214479 · Cited by 14
Mitochondrial metabolism in aging: Effect of dietary interventions
Cerqueira, F. M., & Kowaltowski, A. J. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.03.009 · Cited by 14
PDE 5 inhibitor improves insulin sensitivity by enhancing mitochondrial function in adipocytes
Yu, H. M., Chung, H. K., Kim, K. S., Lee, J. M., Hong, J. H., & Park, K. S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.140 · Cited by 14
Supplementation with Essential Amino Acids in Middle Age Maintains the Health of Rat Kidney
Corsetti, G., Stacchiotti, A., D’Antona, G., Nisoli, E., Dioguardi, F. S., & Rezzani, R. (2010) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201002300214 · Cited by 14
Self-citationGamage, U. S. K., & Morimoto, Y. (2025) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12672 · Cited by 13
Chronic nitric oxide deprivation induces an adaptive antioxidant status in human endothelial cells
Cattaneo, M. G., Cappellini, E., Ragni, M., Tacchini, L., Scaccabarozzi, D., Nisoli, E., & Vicentini, L. M. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.07.026 · Cited by 13
Self-citationAlfaro, G. F., Novak, T. E., Rodning, S. P. P., & Moisá, S. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235481 · Cited by 14
The Mito-Hormetic Mechanisms of Ozone in the Clearance of SARS-CoV2 and in the COVID-19 Therapy
Chirumbolo, S., Varesi, A., Franzini, M., Valdenassi, L., Pandolfi, S., Tirelli, U., Esposito, C., & Ricevuti, G. (2022) · Biomedicines · doi:10.3390/biomedicines10092258 · Cited by 13
p21WAF1/CIP1 deficiency induces mitochondrial dysfunction in HCT116 colon cancer cells
Kim, A. J., Jee, H. J., Song, N., Kim, M., Jeong, S.-Y., & Yun, J. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.11.096 · Cited by 13
Nitric oxide: emerging concepts about its use in cell-based therapies
Brunelli, S., Rovere, P. Q., Sciorati, C., Manfredi, A. A., & Clementi, E. (2006) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.1.33 · Cited by 13
Self-citationKatz, D. H., Lindholm, M. E., & Ashley, E. A. (2024) · Physiology · doi:10.1152/physiol.00024.2024 · Cited by 12
Myoglobin in Brown Adipose Tissue: A Multifaceted Player in Thermogenesis
Aboouf, M. A., Gorr, T. A., Hamdy, N. Μ., Gassmann, M., & Thiersch, M. (2023) · Cells · doi:10.3390/cells12182240 · Cited by 14
Role of nitric oxide on mitochondrial biogenesis during the ovarian cycle
Navarro, A. (2006) · Frontiers in bioscience · doi:10.2741/2134 · Cited by 12
Expression of cGMP-dependent protein kinase type I in mature white adipocytes
Leiss, V., Illison, J., Domes, K., Hofmann, F. B., & Łukowski, R. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.08.071 · Cited by 12
Terasawa, N., & Nakada, K. (2019) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.8.147 · Cited by 12
Coordination of physiologic and toxic pathways in hippocampus by nitric oxide and mitochondria
Laranjinha, J. A. N. (2006) · Frontiers in bioscience · doi:10.2741/2129 · Cited by 12
Lee, H. K., & Shim, E. B. (2013) · Journal of Diabetes Investigation · doi:10.1111/jdi.12048 · Cited by 12
Nitric Oxide Formation From Inorganic Nitrate
Lundberg, J. O., & Weitzberg, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00012-0 · Cited by 13
Cai, J., Luo, L.-M., Tang, H., & Zhou, L. (2018) · Molecular Biology · doi:10.1134/s0026893318040040 · Cited by 12
Zhang, H., Zhao, F., Peng, A., Guo, S., Wang, M., Elsabagh, M., Loor, J. J., & Wang, H. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa133 · Cited by 12
Dietary L-arginine supplementation reduces fat mass in diet-induced obese rats
Jobgen, W. S. (2009) · OakTrust (Texas A&M University Libraries) · Cited by 12
Laird, P.-A. R., Wall, R. M., & Craige, S. M. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156360 · Cited by 14
Nguyen, M., & Ryoo, S. (2017) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2017.21.1.83 · Cited by 11
Genomics as a practical tool in sport - have we reached the starting line?
Williams, A. G., Day, S. H., Lockey, S. J., Heffernan, S. M., & Erskine, R. M. (2014) · e-space (Manchester Metropolitan University) · doi:10.7457/cmep.v3i1 · Cited by 11
Nitrotyrosine impairs mitochondrial function in fetal lamb pulmonary artery endothelial cells
Teng, R., Wu, T.-J., Afolayan, A. J., & Konduri, G. G. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00073.2015 · Cited by 11
Rukavina-mikusic, I. A., Rey, M., Martinefski, M., Tripodi, V. P., & Valdez, L. B. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.11.033 · Cited by 11
Cunningham, R. P., Moore, M. P., Dashek, R. J., Meers, G. M.-E., Jepkemoi, V., Takahashi, T., Vieira‐Potter, V. J., Kanaley, J. A., Booth, F. W., & Rector, R. S. (2022) · Obesity · doi:10.1002/oby.23414 · Cited by 10
Yusof, N. L. M., Affendi, T. N. T. T., Jubaidi, F. F., Zainalabidin, S., & Budin, S. B. (2020) · Sains Malaysiana · doi:10.17576/jsm-2020-4910-15 · Cited by 10
Kim, H. K., Ha, S. H., & Han, J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05623.x · Cited by 10
Exercise and Mitochondrial Function in Adipose Biology: All Roads Lead to NO
Bernlohr, D. (2014) · Diabetes · doi:10.2337/db14-0638 · Cited by 10
The Effects of Dietary Nitrate (Beetroot Juice) Supplementation on Exercise Performance: A Review
Zafeiridis, A. (2014) · American Journal of Sports Science · doi:10.11648/j.ajss.20140204.15 · Cited by 10
Urinary podocyte markers in diabetic kidney disease
Li, C., & Szeto, C. (2024) · Kidney Research and Clinical Practice · doi:10.23876/j.krcp.23.109 · Cited by 9
Mueller, I. A., & O’Brien, K. M. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.10.002 · Cited by 9
Insulin Resistance and Endothelial Dysfunction: Macro and Microangiopathy
Arce‐Esquivel, A. A., Aaron, K. E., Catherine, R., & Laughli, M. H. (2013) · InTech eBooks · doi:10.5772/56475 · Cited by 9
Han, Y., Lin, Y., Xu, J., Cao, L., Liu, X. W., Jiang, H., & Chi, Z. F. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.04.019 · Cited by 9
Rodrigues, G. S., Godinho, R. O., Kiyomoto, B. H., Gamba, J., Oliveira, A. S. B., Schmidt, B., & Tengan, C. H. (2016) · Scientific Reports · doi:10.1038/srep20780 · Cited by 9
Dymkowska, D., Kawalec, M., Wyszomirski, T., & Zabłocki, K. (2017) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2017.10.006 · Cited by 9
Zilocchi, M., Moutaoufik, M. T., Jessulat, M., Phanse, S., Aly, K. A., & Babu, M. (2020) · Expert Review of Proteomics · doi:10.1080/14789450.2020.1723419 · Cited by 10
Gencer, Z. K., Özkırış, M., Göçmen, Y., İntepe, Y. S., Akin, İ., Delibaş, N., & Saydam, L. (2014) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-014-2946-1 · Cited by 9
Sure, V. N. L. R., Sakamuri, S. S. V. P., Orgunati, L., Ageeli, R. Y., Murfee, W. L., & Katakam, P. V. G. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70187 · Cited by 8
Molecular mechanisms attributed to colistin renal proximal tubular epithelial cytotoxicity
Mahmoud, M. A., & Alharbi, M. (2025) · Saudi Pharmaceutical Journal · doi:10.1007/s44446-025-00049-9 · Cited by 8
Luckhart, S., & Riehle, M. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805350-8.00002-7 · Cited by 8
eNOS se correlaciona com a biogênese mitocondrial em corações com cardiopatia congênita e cianose
Xiao, J., Chen, L., Wang, X., Liu, M., & Xiao, Y. (2012) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2012005000072 · Cited by 8
Szabó, G., Hoek, J. B., Darley-Usmar, V. M., Hajnóczky, G., Knudsen, T. B., Mochly‐Rosen, D., & Zakhari, S. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000179318.48376.cd · Cited by 8
da Silva, C. P. V., Delbin, M. A., Guardia, P. G. L., Moura, C. S., Davel, A. P., Priviero, F. B. M., & Zanesco, A. (2015) · Life Sciences · doi:10.1016/j.lfs.2014.12.021 · Cited by 8
Nitric Oxide Formation from Inorganic Nitrate and Nitrite
Lundberg, J. O., & Weitzberg, E. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00016-2 · Cited by 11
5.2 Nitric Oxide in Regulation of Mitochondrial Function, Respiration, and Glycolysis
Bolaños, J. P., & Almeida, Á. (2007) · Springer eBooks · doi:10.1007/978-0-387-30411-3_18 · Cited by 8
Luteotrophic and luteolytic effects of nitric oxide in sheep are dose-dependent in vivo
Keator, C. S., Schreiber, D. T., Hoagland, T. A., & McCracken, J. A. (2008) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2008.02.001 · Cited by 8
Mesarosova, L., Scheper, M., Iyer, A. M., Anink, J. J., Mills, J. D., & Aronica, E. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106587 · Cited by 7
Impact of Vitamin D Supplementation on Inflammatory Markers’ Levels in Obese Patients
Wiciński, M., Ozorowski, M., Wódkiewicz, E., Otto, S. W., Kubiak, K., & Malinowski, B. (2021) · Current Issues in Molecular Biology · doi:10.3390/cimb43030114 · Cited by 7
Kido, K., Suga, T., Tanaka, D., Honjo, T., Fujita, S., Hamaoka, T., & Isaka, T. (2018) · Translational Sports Medicine · doi:10.1002/tsm2.36 · Cited by 7
Mitochondrial function maintenance and mitochondrial training in ageing and related diseases
Gao, G., Xie, Z., & Huang, H. (2025) · Journal of Holistic Integrative Pharmacy · doi:10.1016/j.jhip.2025.04.001 · Cited by 6
Renal mitochondria response to sepsis: a sequential biopsy evaluation of experimental porcine model
Müller, J., Chvojka, J., Ledvinova, L., Beneš, J., Tůma, Z., Grundmanova, M., Jedlička, J., Kuncová, J., & Matějovič, M. (2025) · Intensive Care Medicine Experimental · doi:10.1186/s40635-025-00732-0 · Cited by 6
Majerczak, J., Drzymała‐Celichowska, H., Grandys, M., Kij, A., Kuś, K., Celichowski, J., Kryściak, K., Molik, W. A., Szkutnik, Z., & Zoladz, J. A. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.031085 · Cited by 7
Efectos del óxido nítrico sobre la función cardíaca
Tamargo, J. L., Caballero, R., Gómez, R. J., Núñez, L., Vaquero, M., & Delpón, E. (2006) · Revista Española de Cardiología Suplementos · doi:10.1016/s1131-3587(06)74816-6 · Cited by 6
Nickens, K. P., Han, Y., Shandilya, H., Larrimore, A., Gerard, G. F., Kaldjian, E. P., Patierno, S. R., & Ceryak, S. M. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.10.005 · Cited by 6
Healthspan and Longevity in Mammals: A Family Game for Cellular Organelles?
Nisoli, E., & Valerio, A. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140306093651 · Cited by 6
Self-citationEndocannabinoids and obesity development – the adipose tissue
Nisoli, E. (2010) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2010.12.002 · Cited by 6
Self-citation
Metadata
- Authors
- Nisoli, E., Falcone, S., Tonello, C., Cozzi, V., Palomba, L., Fiorani, M., Pisconti, A., Brunelli, S., Cardile, A., Francolini, M., Cantoni, O., Carruba, M. O., Moncada, S., & Clementi, E.
- Affiliations
- University of Milan (IT)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-11-15
- Volume
- 101
- Issue
- 47
- Pages
- 16507-16512
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC534517
- OpenAlex
- W2116642215
- Cited by
- 495
- References
- 51
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 12 · 2023: 10 · 2022: 12 · 2021: 16 · 2020: 27 · 2019: 25 · 2018: 21 · 2017: 20 · 2016: 17 · 2015: 25 · 2014: 48 · 2013: 24 · 2012: 36
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Update notices
- correction (2005-04-12)
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
- Funders
- Ministero della Salute
- Associazione Italiana per la Ricerca sul Cancro
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial biogenesis, nitric oxide, cGMP signaling, guanylate cyclase, oxidative phosphorylation, ATP production, coupled respiration, endothelial nitric oxide synthase, mitochondrial ultrastructure, muscle mitochondria, oxygen consumption
- MeSH terms
- Adenosine Triphosphate, Animals, Brain, Cell Line, Glycolysis, Cyclic GMP, Humans, Kidney, Mitochondria, Mitochondria, Heart, Mitochondria, Liver, Mitochondria, Muscle, Nitric Oxide, Oxygen Consumption, Transcription, Genetic, PC12 Cells, Mice, Knockout, Nitric Oxide Synthase, U937 Cells, Mice, Rats, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review