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Cited by 111Stress Responses and CortisolNeuropeptides and Animal PhysiologyNeuroscience and Neuropharmacology Research

Tissue plasminogen activator promotes the effects of corticotropin releasing factor on the amygdala and anxiety-like behavior

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Matys, Tomasz, Pawlak, Robert, Matys, Elzbieta, Pavlides, Constantine, McEwen, Bruce S., Strickland, Sidney·2004·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0407355101PMC PMC528975
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Abstract

Stress-induced plasticity in the brain requires a precisely orchestrated sequence of cellular events involving novel as well as well known mediators. We have previously demonstrated that tissue plasminogen activator (tPA) in the amygdala promotes stress-induced synaptic plasticity and anxiety-like behavior. Here, we show that tPA activity in the amygdala is up-regulated by a major stress neuromodulator, corticotropin-releasing factor (CRF), acting on CRF type-1 receptors. Compared with WT, tPA-deficient mice responded to CRF treatment with attenuated expression of c-fos (an indicator of neuronal activation) in the central and medial amygdala but had normal c-fos responses in paraventricular nuclei. They exhibited reduced anxiety-like behavior to CRF but had a sustained corticosterone response after CRF administration. This effect of tPA deficiency was not mediated by plasminogen, because plasminogen-deficient mice demonstrated normal behavioral and hormonal changes to CRF. These studies establish tPA as an important mediator of cellular, behavioral, and hormonal responses to CRF.

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Cited by

Sorted by citations

Related

Authors
Matys, T., Pawlak, R., Matys, E., Pavlides, C., McEwen, B. S., & Strickland, S.
Affiliations
Rockefeller University (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2004-11-02
Volume
101
Issue
46
Pages
16345-16350
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0407355101
PMC
PMC528975
OpenAlex
W1989240245
Cited by
111
References
54
Citations by year
2026: 1 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 2 · 2012: 11
FWCI
1.90
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Leicester Research Archive (University of Leicester) (submittedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS-38472, R01NS035704, NS35704, R01NS038472)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
tissue plasminogen activator, corticotropin-releasing factor, amygdala, anxiety-like behavior, Fos expression, paraventricular nucleus, plasminogen, stress response
MeSH terms
CRF Receptor, Type 1, Amygdala, Animals, Anxiety, Corticotropin-Releasing Hormone, Mice, Inbred C57BL, Plasminogen, Tissue Plasminogen Activator, Recombinant Proteins, Proto-Oncogene Proteins c-fos, Receptors, Corticotropin-Releasing Hormone, Mice, Knockout, Mice

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