The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.
Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses
Open accessAbstract
Fragile X mental retardation is caused by absence of the RNA-binding protein fragile X mental retardation protein (FMRP), encoded by the FMR1 gene. There is increasing evidence that FMRP regulates transport and modulates translation of some mRNAs. We studied neurotransmitter-activated synaptic protein synthesis in fmr1 -knockout mice. Synaptoneurosomes from knockout mice did not manifest accelerated polyribosome assembly or protein synthesis as it occurs in wild-type mice upon stimulation of group I metabotropic glutamate receptors. Direct activation of protein kinase C did not compensate in the knockout mouse, indicating that the FMRP-dependent step is further along the signaling pathway. Visual cortices of young knockout mice exhibited a lower proportion of dendritic spine synapses containing polyribosomes than did the cortices of wild-type mice, corroborating this finding in vivo . This deficit in rapid neurotransmitter-controlled local translation of specific proteins may contribute to morphological and functional abnormalities observed in patients with fragile X syndrome.
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“However, we did not observe an increase in overall protein synthesis in response to DHPG, whereas Weiler and colleagues [31] observed a 1.3-fold increase in 35S-Met incorporation after 5 min of stimulation.”
From FMRP Mediates mGluR5-Dependent Translation of Amyloid Precursor Protein (2007) · cites this paper as [31]
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“Therefore, FMRP was not required for basal protein synthesis, which is in agreement with a prior report [31].”
From FMRP Mediates mGluR5-Dependent Translation of Amyloid Precursor Protein (2007) · cites this paper as [31]
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Cites
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Altered synaptic plasticity in a mouse model of fragile X mental retardation
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Fragile X clinical features and neurobiology
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Fmr1 exon 14 skipping in late embryonic development of the rat forebrain
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Additional file 1 of Fmr1 exon 14 skipping in late embryonic development of the rat forebrain
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Dissecting the role of calcium signaling in Fragile X syndrome
Castagnola, S. (2019) · theses.fr (ABES) · doi:10.70675/3d35096bz79d0z46edz8a70zb783a8f60257
Paluszkiewicz, S. M. (2011) · DigitalGeorgetown (Georgetown University Library)
ROLE OF DENDRITIC BDNF SYNTHESIS IN ADULT NEUROGENESIS AND SPINE MORPHOGENESIS
Waterhouse, E. G. (2011) · DigitalGeorgetown (Georgetown University Library)
Metadata
- Authors
- Weiler, I. J., Spangler, C. C., Klintsova, A. Y., Grossman, A. W., Kim, S. H., Bertaina-Anglade, V., Khaliq, H., de Vries, F. E., Lambers, F. A. E., Hatia, F., Base, C. K., & Greenough, W. T.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Beckman Institute, Neuroscience Program, and Departments of Psychology, Psychiatry, and Cell and Structural Biology, University of Illinois at Urbana–Champaign, Urbana, IL 61801
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-11-17
- Volume
- 101
- Issue
- 50
- Pages
- 17504-17509
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC536018
- OpenAlex
- W2007532395
- Cited by
- 210
- References
- 52
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 8 · 2016: 4 · 2015: 10 · 2014: 7 · 2013: 7 · 2012: 16
- FWCI
- 11.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- FRAXA Research Foundation (MH35321)
- Universiteit Antwerpen
- National Institutes of Health (5r03hd035565-02, 5r01hd037175-03)
- National Institute of Mental Health (MH-35321, R01MH035321, R37MH035321)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R03 HD 35565-01, HD 37175)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- FMRP, fragile X syndrome, FMR1 gene, synaptic protein synthesis, local translation, group I metabotropic glutamate receptors, protein kinase C, dendritic spines, synaptoneurosomes, visual cortex, Fmr1 knockout mice, RNA-binding proteins
- MeSH terms
- Animals, Glycine, Methionine, Microscopy, Electron, Nerve Tissue Proteins, Potassium, Resorcinols, Ribosomes, Synapses, Protein Biosynthesis, RNA-Binding Proteins, Gene Deletion, Mice, Knockout, Neurotransmitter Agents, Mice, Fragile X Messenger Ribonucleoprotein 1, Fragile X Mental Retardation Protein
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