Cited by 211Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology ResearchRNA and protein synthesis mechanisms

The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.

Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses

Open access

Weiler, Ivan Jeanne, Spangler, Chad C., Klintsova, Anna Y., Grossman, Aaron W., Kim, Soong Ho, Bertaina-Anglade, Valerie, Khaliq, Hooma, de Vries, Froukje E., Lambers, Femke A. E., Hatia, Fatima, Base, Christine K., Greenough, William T.·2004·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0407533101PMC PMC536018

Open this paper in CoChat — free account

Abstract

Fragile X mental retardation is caused by absence of the RNA-binding protein fragile X mental retardation protein (FMRP), encoded by the FMR1 gene. There is increasing evidence that FMRP regulates transport and modulates translation of some mRNAs. We studied neurotransmitter-activated synaptic protein synthesis in fmr1 -knockout mice. Synaptoneurosomes from knockout mice did not manifest accelerated polyribosome assembly or protein synthesis as it occurs in wild-type mice upon stimulation of group I metabotropic glutamate receptors. Direct activation of protein kinase C did not compensate in the knockout mouse, indicating that the FMRP-dependent step is further along the signaling pathway. Visual cortices of young knockout mice exhibited a lower proportion of dendritic spine synapses containing polyribosomes than did the cortices of wild-type mice, corroborating this finding in vivo . This deficit in rapid neurotransmitter-controlled local translation of specific proteins may contribute to morphological and functional abnormalities observed in patients with fragile X syndrome.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.0407533101

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The unbiased estimation of number and sizes of arbitrary particles using the disector
Sterio, D. C. (1984) · Journal of Microscopy · doi:10.1111/j.1365-2818.1984.tb02501.x · Cited by 2,533
The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis
Gundersen, H. J. G., Bagger, P. V., Bendtsen, T. F., Evans, S. M., Korbo, L., Marcussen, N., Møller, A., Nielsen, K. N., Nyengaard, J. R., Pakkenberg, B., et al. (1988) · Apmis · doi:10.1111/j.1699-0463.1988.tb00954.x · Cited by 2,480
Altered synaptic plasticity in a mouse model of fragile X mental retardation
Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349
Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome
Brown, V., Jin, P., Ceman, S., Darnell, J. C., O'Donnell, W. T., Tenenbaum, S. A., Jin, X., Feng, Y., Wilkinson, K. D., Keene, J. D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00568-2 · Cited by 1,109
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,108
Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
Comery, T. A., Harris, J. B., Willems, P. J., Oostra, B. A., Irwin, S. A., Weiler, I. J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5401 · Cited by 1,046
Self-citation
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
Darnell, J. C., Jensen, K. B., Jin, P., Brown, V., Warren, S. T., & Darnell, R. B. (2001) · Cell · doi:10.1016/s0092-8674(01)00566-9 · Cited by 952
The FMR–1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation
Devys, D., Lutz, Y., Rouyer, N., Bellocq, J., & Mandel, J. (1993) · Nature Genetics · doi:10.1038/ng0893-335 · Cited by 781
Protein synthesis at synaptic sites on dendrites.
Steward, O., & Schuman, E. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.299 · Cited by 731
Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation
Weiler, I. J., Irwin, S. A., Klintsova, A. Y., Spencer, C. M., Brazelton, A. D., Miyashiro, K., Comery, T. A., Patel, B., Eberwine, J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5395 · Cited by 644
Self-citation

Show all 52 references

Research works printed but not linked: 3

Stefani, G., Fraser, C. E., Darnell, J. C. & Darnell, R. B. (2004) J. Neurosci. 24, 9272–9276.
Bakker, C. E., Verheij, C., Willemsen, R., van der Helm, R., Oerlemans, F., Vermey, M., Bygrave, A., Hoogeveen, A. T., Oostra, B. A., Reyniers, E., et al. (1994) Cell 78, 23–33.8033209
Klintsova, A. Y., Matthews, J. T., Goodlett, C. R., Napper, R. M. & Greenough, W. T. (1997) Alcohol. Clin. Exp. Res. 21, 1257–1263.9347087

Sorted by citations

Trinucleotide Repeat Disorders
Orr, H. T., & Zoghbi, H. Y. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113042 · Cited by 1,394
Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function
Bassell, G. J., & Warren, S. T. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.004 · Cited by 1,051
Fragile X syndrome
Hagerman, R. J., Berry-Kravis, E., Hazlett, H. C., Bailey, D. B., Moine, H., Kooy, R. F., Tassone, F., Gantois, I., Sonenberg, N., Mandel, J. L., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.65 · Cited by 838
Advances in the Treatment of Fragile X Syndrome
Hagerman, R. J., Berry-Kravis, E., Kaufmann, W. E., Ono, M. Y., Tartaglia, N., Lachiewicz, A., Kronk, R., Delahunty, C., Hessl, D., Visootsak, J., et al. (2009) · Pediatrics · doi:10.1542/peds.2008-0317 · Cited by 596
Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD
Park, S., Park, J. M., Kim, S., Kim, J.-A., Shepherd, J. D., Smith-Hicks, C. L., Chowdhury, S., Kaufmann, W., Kuhl, D., Ryazanov, A. G., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.023 · Cited by 516
Self-citation
From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome
Bagni, C., & Greenough, W. T. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1667 · Cited by 475
Self-citation
Dynamic Translational and Proteasomal Regulation of Fragile X Mental Retardation Protein Controls mGluR-Dependent Long-Term Depression
Hou, L., Antion, M. D., Hu, D., Spencer, C. M., Paylor, R., & Klann, E. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.005 · Cited by 469
Dysregulated Metabotropic Glutamate Receptor-Dependent Translation of AMPA Receptor and Postsynaptic Density-95 mRNAs at Synapses in a Mouse Model of Fragile X Syndrome
Muddashetty, R. S., Kelić, S., Gross, C., Xu, M., & Bassell, G. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0937-07.2007 · Cited by 421
A pilot open label, single dose trial of fenobam in adults with fragile X syndrome
Berry-Kravis, E., Hessl, D., Coffey, S., Hervey, C., Schneider, A., Yuhas, J., Hutchison, J., Snape, M., Tranfaglia, M., Nguyen, D. V., et al. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.063701 · Cited by 411
Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome
Osterweil, E. K., Krueger, D. D., Reinhold, K., & Bear, M. F. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3888-10.2010 · Cited by 384
New insights into the role of brain-derived neurotrophic factor in synaptic plasticity
Waterhouse, E. G., & Xu, B. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.06.009 · Cited by 352
Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice
de Vrij, F. M. S., Levenga, J., van der Linde, H. C., Koekkoek, S. K., De Zeeuw, C. I., Nelson, D. L., Oostra, B. A., & Willemsen, R. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.04.002 · Cited by 313
Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome
Zhao, M.-G., Toyoda, H., Ko, S. W., Ding, H.-K., Wu, L.-J., & Zhuo, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1520-05.2005 · Cited by 296
Dysregulation and restoration of translational homeostasis in fragile X syndrome
Richter, J. D., Bassell, G. J., & Klann, E. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4001 · Cited by 275
FMRP Mediates mGluR5-Dependent Translation of Amyloid Precursor Protein
Westmark, C. J., & Malter, J. S. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050052 · Cited by 296
“). Therefore, FMRP was not required for basal protein synthesis, which is in agreement with a prior report [”
Result
Metabotropic Receptor-Dependent Long-Term Depression Persists in the Absence of Protein Synthesis in the Mouse Model of Fragile X Syndrome
Nosyreva, E. D., & Huber, K. M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01316.2005 · Cited by 301
Postadolescent Changes in Regional Cerebral Protein Synthesis: An In Vivo Study in the Fmr1 Null Mouse
Qin, M., Kang, J., Burlin, T. V., Jiang, C., & Smith, C. B. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0093-05.2005 · Cited by 263
Dendritic spines: Revisiting the physiological role
Chidambaram, S. B., Rathipriya, A. G., Bolla, S. R., Bhat, A., Ray, B., Mahalakshmi, A. M., Manivasagam, T., Thenmozhi, A. J., Essa, M. M., Guillemin, G. J., et al. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.01.005 · Cited by 266
Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABA B Receptors with Arbaclofen
Henderson, C., Wijetunge, L., Kinoshita, M. N., Shumway, M., Hammond, R. S., Postma, F. R., Brynczka, C., Rush, R., Thomas, A., Paylor, R., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004218 · Cited by 249
Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome
Gross, C., Nakamoto, M., Yao, X., Chan, C.-B., Yim, S. Y., Ye, K., Warren, S. T., & Bassell, G. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0402-10.2010 · Cited by 241
Homer Interactions Are Necessary for Metabotropic Glutamate Receptor-Induced Long-Term Depression and Translational Activation
Ronesi, J. A., & Huber, K. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5019-07.2008 · Cited by 244
Brain-Derived Neurotrophic Factor Rescues Synaptic Plasticity in a Mouse Model of Fragile X Syndrome
Lauterborn, J. C., Rex, C. S., Kramár, E. A., Chen, L. Y., Pandyarajan, V., LYNCH, G. S., & Gall, C. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2624-07.2007 · Cited by 244
FMRP Phosphorylation Reveals an Immediate-Early Signaling Pathway Triggered by Group I mGluR and Mediated by PP2A
Narayanan, U., Nalavadi, V., Nakamoto, M., Pallas, D. C., Ceman, S., Bassell, G. J., & Warren, S. T. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2969-07.2007 · Cited by 228
The trouble with spines in fragile X syndrome: density, maturity and plasticity
He, C. X., & Portera‐Cailliau, C. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.049 · Cited by 217
Open-Label Treatment Trial of Lithium to Target the Underlying Defect in Fragile X Syndrome
Berry-Kravis, E., Sumis, A., Hervey, C., Nelson, M., Porges, S. W., Weng, N., Weiler, I. J., & Greenough, W. T. (2008) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0b013e31817dc447 · Cited by 215
Self-citation
RNA TRANSPORT AND LOCAL CONTROL OF TRANSLATION
Kindler, S., Wang, H., Richter, D., & Tiedge, H. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.122303.120653 · Cited by 215
The State of Synapses in Fragile X Syndrome
Pfeiffer, B. E., & Huber, K. M. (2009) · The Neuroscientist · doi:10.1177/1073858409333075 · Cited by 216
Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory
Bolduc, F. V., Bell, K., Cox, H., Broadie, K. S., & Tully, T. (2008) · Nature Neuroscience · doi:10.1038/nn.2175 · Cited by 211
Decreased Nociceptive Sensitization in Mice Lacking the Fragile X Mental Retardation Protein: Role of mGluR1/5 and mTOR
Price, T. J., Rashid, M. H., Millecamps, M., Sanoja, R., Entrena, J. M., & Cerveró, F. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4383-07.2007 · Cited by 220
Hippocampal pyramidal cells in adult Fmr1 knockout mice exhibit an immature-appearing profile of dendritic spines
Grossman, A. W., Elisseou, N. M., McKinney, B. C., & Greenough, W. T. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.044 · Cited by 206
Self-citation
Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models
Gatto (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00004 · Cited by 204
Lessons from Fragile X Regarding Neurobiology, Autism, and Neurodegeneration
Hagerman, R. J. (2006) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-200602000-00012 · Cited by 200
The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer
Didiot, M.-C., Tian, Z., Schaeffer, C., Subramanian, M., Mandel, J., & Moine, H. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn472 · Cited by 196
Spatially restricting gene expression by local translation at synapses
Wang, D. O., Martin, K. C., & Zukin, R. S. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.01.005 · Cited by 196
Local translational control in dendrites and its role in long‐term synaptic plasticity
Sutton, M. A., & Schuman, E. M. (2005) · Journal of Neurobiology · doi:10.1002/neu.20152 · Cited by 195
Dendritic pathology in mental retardation: from molecular genetics to neurobiology
Dierssen, M., & Ramakers, G. J. A. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00224.x · Cited by 191
Increased Threshold for Spike-Timing-Dependent Plasticity Is Caused by Unreliable Calcium Signaling in Mice Lacking Fragile X Gene Fmr1
Meredith, R. M., Holmgren, C. D., Weidum, M., Burnashev, N., & Mansvelder, H. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.028 · Cited by 190
FMRP Acts as a Key Messenger for Dopamine Modulation in the Forebrain
Wang, H., Wu, L.-J., Kim, S. S., Lee, F. J. S., Gong, B., Toyoda, H., Ren, M., Shang, Y.-Z., Xu, H., Liu, F., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.027 · Cited by 186
Self-citation
CGG repeat in the FMR1 gene: size matters
Willemsen, R., Levenga, J., & Oostra, B. (2011) · Clinical Genetics · doi:10.1111/j.1399-0004.2011.01723.x · Cited by 184
Fragile X mental retardation protein induces synapse loss through acute postsynaptic translational regulation
Pfeiffer, B. E., & Huber, K. M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0054-07.2007 · Cited by 189
RNA binding proteins and the regulation of neuronal synaptic plasticity
Ule, J., & Darnell, R. B. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.01.003 · Cited by 181
Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
Grossman, A. W., Aldridge, G. M., Weiler, I. J., & Greenough, W. T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1790-06.2006 · Cited by 177
Self-citation
Altered differentiation of neural stem cells in fragile X syndrome
Castrén, M., Tervonen, T., Kärkkäinen, V., Heinonen, S., Castrén, E., Larsson, K., Bakker, C. E., Oostra, B. A., & Åkerman, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508995102 · Cited by 176
GPCR Interacting Proteins (GIPs) in the Nervous System: Roles in Physiology and Pathologies
Bockaert, J., Perroy, J., Bécamel, C., Marin, P., & Fagni, L. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105705 · Cited by 185
Current advances in local protein synthesis and synaptic plasticity
Pfeiffer, B. E., & Huber, K. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1797-06.2006 · Cited by 168
Dendritic mRNAs encode diversified functionalities in hippocampal pyramidal neurons
Zhong, J. W., Zhang, T., & Bloch, L. M. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-17 · Cited by 162
Multiple Gq-Coupled Receptors Converge on a Common Protein Synthesis-Dependent Long-Term Depression That Is Affected in Fragile X Syndrome Mental Retardation
Volk, L. J., Pfeiffer, B. E., Gibson, J. R., & Huber, K. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2266-07.2007 · Cited by 166
Seizures in Fragile X Syndrome: Characteristics and Comorbid Diagnoses
Berry-Kravis, E., Raspa, M., Loggin-Hester, L., Bishop, E., Holiday, D., & Bailey, D. B. (2010) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/1944-7558-115.6.461 · Cited by 155
Fragile X targeted pharmacotherapy: lessons learned and future directions
Erickson, C. A., Davenport, M. H., Schaefer, T. L., Wink, L. K., Pedapati, E. V., Sweeney, J. A., Fitzpatrick, S. E., Brown, W. T., Budimirovic, D. B., Hagerman, R. J., et al. (2017) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-017-9186-9 · Cited by 157
Transcription, translation and fragile X syndrome
Garber, K. B., Smith, K. T., Reines, D., & Warren, S. T. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.04.010 · Cited by 148
Drosophilafragile X mental retardation protein developmentally regulates activity-dependent axon pruning
Tessier, C. R., & Broadie, K. S. (2008) · Development · doi:10.1242/dev.015867 · Cited by 147
The Role of Co-chaperones in Synaptic Proteostasis and Neurodegenerative Disease
Gorenberg, E. L., & Chandra, S. S. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00248 · Cited by 134
Therapeutic implications of the mGluR theory of fragile X mental retardation
Bear, M. F. (2005) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00135.x · Cited by 137
A reduced number of metabotropic glutamate subtype 5 receptors are associated with constitutive homer proteins in a mouse model of fragile X syndrome
Giuffrida, R., Musumeci, S., D'Antoni, S., Bonaccorso, C. M., Giuffrida-Stella, A. M., Oostra, B. A., & Catania, M. V. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0932-05.2005 · Cited by 141
Age-dependent and selective impairment of long-term potentiation in the anterior piriform cortex of mice lacking the fragile X mental retardation protein
Larson, J., Jessen, R. E., Kim, D., Fine, A.-K. S., & du Hoffmann, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2638-05.2005 · Cited by 135
Diverse Roles of Rho Family GTPases in Neuronal Development, Survival, and Death
Linseman, D. (2008) · Frontiers in Bioscience · doi:10.2741/2710 · Cited by 134
The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules
Davidovic, L., Jaglin, X. H., Lepagnol-Bestel, A.-M., Tremblay, S., Simonneau, M., Bardoni, B., & Khandjian, E. W. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm263 · Cited by 134
AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome
Levenga, J., Hayashi, S., de Vrij, F. M. S., Koekkoek, S. K. E., van der Linde, H. C., Nieuwenhuizen, I. M., Song, C., Buijsen, R. A. M., Pop, A. S., Gomez‐Mancilla, B., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.022 · Cited by 122
The fragile X mental retardation protein–RNP granules show an mGluR-dependent localization in the post-synaptic spines
Ferrari, F., Mercaldo, V., Piccoli, G., Sala, C., Cannata, S. M., Achsel, T., & Bagni, C. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.11.015 · Cited by 125
Molecular regulation of dendritic spine dynamics and their potential impact on synaptic plasticity and neurological diseases
Maiti, P., Manna, J., Ilavazhagan, G., Rossignol, J., & Dunbar, G. L. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.09.020 · Cited by 128
Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome
Gross, C., Chang, C.-W., Kelly, S. M., Bhattacharya, A., McBride, S. M. J., Danielson, S. W., Jiang, M. Q., Chan, C. B., Ye, K., Gibson, J. R., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.060 · Cited by 117
Modeling psychiatric disorders at the cellular and network levels
Brennand, K. J., Simone, A., Tran, N., & Gage, F. H. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.20 · Cited by 119
Increased Secreted Amyloid Precursor Protein-α (sAPPα) in Severe Autism: Proposal of a Specific, Anabolic Pathway and Putative Biomarker
Ray, B., Long, J. M., Sokol, D. K., & Lahiri, D. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020405 · Cited by 120
BC1 Regulation of Metabotropic Glutamate Receptor-Mediated Neuronal Excitability
Zhong, J. W., Chuang, S.-C., Bianchi, R., Zhao, W., Lee, H., Fenton, A. A., Wong, R. K. S., & Tiedge, H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3893-08.2009 · Cited by 120
microRNA Regulation of Synaptic Plasticity
Smalheiser, N. R., & Lugli, G. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8065-2 · Cited by 119
Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model
Goebel‐Goody, S. M., Wilson‐Wallis, E. D., Royston, S., Tagliatela, S. M., Naegele, J. R., & Lombroso, P. J. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00781.x · Cited by 108
Characterization of the Role of Microtubule-Associated Protein 1B in Metabotropic Glutamate Receptor-Mediated Endocytosis of AMPA Receptors in Hippocampus
Davidkova, G., & Carroll, R. C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3334-07.2007 · Cited by 112
microRNA involvement in developmental and functional aspects of the nervous system and in neurological diseases
Christensen, M., & Schratt, G. M. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.04.043 · Cited by 113
Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome
Kim, S. H., Markham, J. A., Weiler, I. J., & Greenough, W. T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800257105 · Cited by 97
Self-citation
Post-transcriptional Stimulation of Gene Expression by MicroRNAs
Lee, S., & Vasudevan, S. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5107-5_7 · Cited by 108
Therapeutic Strategies in Fragile X Syndrome: Dysregulated mGluR Signaling and Beyond
Groß, C., Berry‐Kravis, E., & Bassell, G. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.137 · Cited by 109
Fragile X Syndrome and Targeted Treatment Trials
Hagerman, R. J., Lauterborn, J. C., Au, J., & Berry‐Kravis, E. (2011) · Results and problems in cell differentiation · doi:10.1007/978-3-642-21649-7_17 · Cited by 111
Targeted treatments for fragile X syndrome
Berry‐Kravis, E., Knox, A. T., & Hervey, C. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-011-9074-7 · Cited by 108
Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders
Francis, S. M., Sagar, A., Levin-Decanini, T., Liu, W., Carter, C. S., & Jacob, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.021 · Cited by 101
Deregulated mTOR-mediated translation in intellectual disability
Troca-Marín, J. A., Alves-Sampaio, A., & Montesinos, M. L. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.01.005 · Cited by 109
Haploinsufficiency of Cyfip1 Produces Fragile X-Like Phenotypes in Mice
Bozdagi, O., Sakurai, T., Dorr, N., Pilorge, M., Takahashi, N., & Buxbaum, J. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042422 · Cited by 97
Update on the implication of potassium channels in autism: K+ channelautism spectrum disorder
Guglielmi, L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00034 · Cited by 89
Modulation of dendritic spines and synaptic function by Rac1: A possible link to Fragile X syndrome pathology
Bongmba, O. Y. N., Martinez, L. A., Elhardt, M. E., Butler, K., & Tejada-Simon, M. V. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.020 · Cited by 91
Attentional dysfunction, impulsivity, and resistance to change in a mouse model of fragile X syndrome.
Moon, J., Beaudin, A. E., Verosky, S. C., Driscoll, L. L., Weiskopf, M., Levitsky, D. A., Crnic, L. S., & Strupp, B. J. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.6.1367 · Cited by 91
Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach usPreprint
Santos, A. R., Kanellopoulos, A. K., & Bagni, C. (2014) · Learning & Memory · doi:10.1101/lm.035956.114 · Cited by 91
Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity
Clifton, N. E., Trent, S., Thomas, K. L., & Hall, J. (2019) · Complex Psychiatry · doi:10.1159/000500267 · Cited by 88
The RNA binding protein CPEB regulates dendrite morphogenesis and neuronal circuit assembly in vivo
Bestman, J. E., & Cline, H. T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806296105 · Cited by 81
Differential translation and fragile X syndrome
Vanderklish, P. W., & Edelman, G. M. (2005) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00134.x · Cited by 59
RNA-binding proteins in neurological diseases
Zhou, H.-L., Mangelsdorf, M., Liu, J., Zhu, L., & Wu, J. Y. (2014) · Science China Life Sciences · doi:10.1007/s11427-014-4647-9 · Cited by 82
Developmental characteristics of dendritic spines in the dentate gyrus of Fmr1 knockout mice
Grossman, A. W., Aldridge, G. M., Lee, K. J., Zeman, M. K., Jun, C. S., Azam, H. S., Arii, T., Imoto, K., Greenough, W. T., & Rhyu, I. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.07.090 · Cited by 79
Self-citation
The RNA binding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons
Price, T. J., Flores, C. M., Cerveró, F., & Hargreaves, K. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.05.047 · Cited by 76
Selective Role of the Catalytic PI3K Subunit p110β in Impaired Higher Order Cognition in Fragile X Syndrome
Gross, C., Raj, N., Molinaro, G., Allen, A. G., Whyte, A. J., Gibson, J. R., Huber, K. M., Gourley, S. L., & Bassell, G. J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.065 · Cited by 71
Fragile X mental retardation protein is required for chemically‐induced long‐term potentiation of the hippocampus in adult mice
Shang, Y., Wang, H., Mercaldo, V., Li, X., Chen, T., & Zhuo, M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06314.x · Cited by 72
A trace of silence: memory and microRNA at the synapse
Ashraf, S. I., & Kunes, S. M. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.08.007 · Cited by 73
Early‐phase ERK activation as a biomarker for metabolic status in fragile X syndrome
Weng, N., Weiler, I. J., Sumis, A. M., Berry‐Kravis, E., & Greenough, W. T. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30765 · Cited by 72
Self-citation
microRNAs: tiny regulators of synapse function in development and disease
Bicker, S., & Schratt, G. M. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00400.x · Cited by 72
Behavioral and Neurochemical Alterations in Mice Lacking the RNA-Binding Protein Translin
Stein, J. M., Bergman, W., Fang, Y., Davison, L., Brensinger, C. M., Robinson, M. B., Hecht, N. B., & Abel, T. G. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4437-05.2006 · Cited by 71
The Thorny Side of Addiction: Adaptive Plasticity and Dendritic Spines
Mulholland, P. J., & Chandler, L. J. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.247 · Cited by 69
Loss of the Fragile X Mental Retardation Protein Decouples Metabotropic Glutamate Receptor Dependent Priming of Long-Term Potentiation From Protein Synthesis
Auerbach, B. D., & Bear, M. F. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00449.2010 · Cited by 71
Excess Protein Synthesis in FXS Patient Lymphoblastoid Cells Can Be Rescued with a p110β-Selective Inhibitor
Groß, C., & Bassell, G. J. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00363 · Cited by 70
Which Comes First in Fragile X Syndrome, Dendritic Spine Dysgenesis or Defects in Circuit Plasticity?
Portera‐Cailliau, C. (2011) · The Neuroscientist · doi:10.1177/1073858410395322 · Cited by 72
BDNF in fragile X syndrome
Castrén, M. L., & Ċastrén, E. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.018 · Cited by 68
Dynamic Association of the Fragile X Mental Retardation Protein as a Messenger Ribonucleoprotein between Microtubules and Polyribosomes
Wang, H., Dictenberg, J. B., Ku, L., Li, W., Bassell, G. J., & Feng, Y. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-06-0583 · Cited by 71
Neuroanatomical, molecular genetic, and behavioral correlates of fragile X syndrome
Koukoui, S., & Chaudhuri, A. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.06.001 · Cited by 65
Open-label riluzole in fragile X syndrome
Erickson, C. A., Weng, N., Weiler, I. J., Greenough, W. T., Stigler, K. A., Wink, L. K., & McDougle, C. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.10.108 · Cited by 67
Self-citation

Authors: Weiler, I. J., Spangler, C. C., Klintsova, A. Y., Grossman, A. W., Kim, S. H., Bertaina-Anglade, V., Khaliq, H., de Vries, F. E., Lambers, F. A. E., Hatia, F., Base, C. K., & Greenough, W. T.
Affiliations: University of Illinois Urbana-Champaign (US)
Beckman Institute, Neuroscience Program, and Departments of Psychology, Psychiatry, and Cell and Structural Biology, University of Illinois at Urbana–Champaign, Urbana, IL 61801
ORCID: Klintsova, Anna Y.
Grossman, Aaron W.
de Vries, Froukje E.
Lambers, Femke A. E.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2004-11-17
Volume: 101
Issue: 50
Pages: 17504-17509
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0407533101
PMC: PMC536018
OpenAlex: W2007532395
Cited by: 210
References: 52
Citations by year: 2025: 1 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 8 · 2016: 4 · 2015: 10 · 2014: 7 · 2013: 7 · 2012: 16
FWCI: 11.25
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: FRAXA Research Foundation (MH35321)
Universiteit Antwerpen
National Institutes of Health (5r03hd035565-02, 5r01hd037175-03)
National Institute of Mental Health (MH-35321, R01MH035321, R37MH035321)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R03 HD 35565-01, HD 37175)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: FMRP, fragile X syndrome, FMR1 gene, synaptic protein synthesis, local translation, group I metabotropic glutamate receptors, protein kinase C, dendritic spines, synaptoneurosomes, visual cortex, Fmr1 knockout mice, RNA-binding proteins
MeSH terms: Animals, Glycine, Methionine, Microscopy, Electron, Nerve Tissue Proteins, Potassium, Resorcinols, Ribosomes, Synapses, Protein Biosynthesis, RNA-Binding Proteins, Gene Deletion, Mice, Knockout, Neurotransmitter Agents, Mice, Fragile X Messenger Ribonucleoprotein 1, Fragile X Mental Retardation Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks