The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation.
Open accessAbstract
Dendritic spines are small protrusions from dendritic shafts that contain the postsynaptic sites of glutamatergic synapses in the brain. Spines undergo dramatic activity-dependent structural changes that are particularly prominent during neuronal development. Although changes in spine shape or number have been proposed to contribute to forms of synaptic plasticity that underlie learning and memory, the extent to which spines remain plastic in the adult brain is unclear. We find that induction of long-term potentiation (LTP) of synaptic transmission in acute hippocampal slices of adult mice evokes a reliable, transient expansion in spines that are synaptically activated, as determined with calcium imaging. Similar to LTP, transient spine expansion requires N-methyl-D-aspartate (NMDA) receptor-mediated Ca2+ influx and actin polymerization. Moreover, like the early phase of LTP induced by the stimulation protocol, spine expansion does not require Ca2+ influx through L-type voltage-gated Ca2+ channels nor does it require protein synthesis. Thus, transient spine expansion is a characteristic feature of the initial phases of plasticity at mature synapses and so may contribute to synapse remodeling important for LTP.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Aerobic exercise has also been associated with certain morphological changes to the structure of neural cells, which may be important in facilitating hippocampal learning and memory (Lang et al., 2004).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Lang et al., 2004
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP
Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00084-2 · Cited by 3,042
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
Trachtenberg, J. T., Chen, B. E., Knott, G. W., Feng, G., Sanes, J. R., Welker, E., & Svoboda, K. (2002) · Nature · doi:10.1038/nature01273 · Cited by 1,927
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Engert, F., & Bonhoeffer, T. (1999) · Nature · doi:10.1038/19978 · Cited by 1,412
Morphological Changes in Dendritic Spines Associated with Long-Term Synaptic Plasticity
Yuste, R., & Bonhoeffer, T. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1071 · Cited by 1,269
Structure and function of dendritic spines
Nimchinsky, E. A., Sabatini, B. L., & Svoboda, K. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.160008 · Cited by 1,208
Long-term dendritic spine stability in the adult cortex
Grutzendler, J., Kasthuri, N., & Gan, W.-B. (2002) · Nature · doi:10.1038/nature01276 · Cited by 1,198
Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity
Maletic-Savatic, M., Malinow, R., & Svoboda, K. (1999) · Science · doi:10.1126/science.283.5409.1923 · Cited by 1,009
Dendritic spines as basic functional units of neuronal integration
Yuste, R., & Denk, W. (1995) · Nature · doi:10.1038/375682a0 · Cited by 950
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
Toni, N., Buchs, P.-A., Nikonenko, I., Bron, C. R., & Muller, D. (1999) · Nature · doi:10.1038/46574 · Cited by 949
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–245 of 245
Mechanisms of functional and morphological synapse plasticity
Maximov, D. (2026) · Biosystems · doi:10.1016/j.biosystems.2026.105786 · Cited by 2
Accelerators, Brakes, and Gears of Actin Dynamics in Dendritic Spines
Pontrello, C. G., & Ethell, I. M. (2014) · The Open Neuroscience Journal · doi:10.2174/1874082000903010067 · Cited by 1
Dendritic Elaboration: Morphology and Chemistry
Rollenhagen, A., & Lübke, J. H. R. (2022) · Springer eBooks · doi:10.1007/978-3-030-88832-9_11 · Cited by 1
Dendritic Organelles for Postsynaptic Trafficking
Hanus, C., & Ehlers, M. (2008) · Springer eBooks · doi:10.1007/978-0-387-77232-5_8 · Cited by 1
Recovery of function after lesions of the anterior thalamic nuclei: CA1 neuromorphology
Harland, B. C. (2013) · doi:10.26021/5935 · Cited by 1
Vadakkan, K. I. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/085589 · Cited by 1
Chen, L. Y., Haile, M. T., Khoja, S., de Carvalho, G., & Hunt, R. F. (2022) · Research Square · doi:10.21203/rs.3.rs-2265451/v1 · Cited by 1
Synapses, spines, zinc and pathology of Alzheimer's disease.
Familtsev, D. (2013) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/420 · Cited by 1
Young, P. A. (2010) · IUScholarWorks (Indiana University) · doi:10.7912/c2/2126 · Cited by 1
PKMζ, LTP Maintenance, and Long-Term Memory Storage
Sacktor, T. C. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00022-x
Role of mGluR5 and FMRP in mouse primary somatosensory cortex
Wijetunge, L. S. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
Genetic Marker Mice and Their Use in Understanding Learning and Memory
Murphy, M., Yvette, M., & Butler, C. (2013) · InTech eBooks · doi:10.5772/56498
Optical analysis of synaptic plasticity in rat hippocampus
Zhang, Y. (2008) · edoc (University of Basel) · doi:10.5451/unibas-004414662
Imaging activity-dependent structural and functional plasticity of hippocampal CA3-CA1 synapses
Becker, N. (2008) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.10129
Abbas, A.-K. (2015) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Bowden, J. B., Abraham, W. C., & Harris, K. M. (2010) · Otago University Research Archive (University of Otago)
Imaging cellular mechanisms of presynaptic structural plasticity
Helling, I. (2009)
The Effects of Androgens on Hippocampal Synaptic Plasticity in Male Mammals
Mendell, A. L. (2014) · The Atrium (University of Guelph)
Biochemical and functional characterization of RhoSAP: a RhoGAP of the postsynaptic density
Dahl, J. (2008) · OPen Access Repositorium der Universität Ulm (OPARU) (Ulm University) · doi:10.18725/oparu-1556
Analysis of Myosin VI in Drosophila melanogaster Synaptic Function and Development
Kisiel, M. (2014) · Library and Archives Canada (Government of Canada)
NOVEL APPROACHES TO THE STUDY OF SYNAPTIC PLASTICITY IN THE RAT HIPPOCAMPUS
Podor, B. (2017) · DalSpace (Dalhousie University)
Profilin isoforms in the hippocampus in health and disease
Zessin, S. (2014) · Digitale Bibliothek Braunschweig (Verbundzentrale Göttingen (VZG)) · doi:10.24355/dbbs.084-201501221125-0
Visualizing inhibitory and excitatory synapse dynamics In vivo
Berry, K. (2018) · DSpace@MIT (Massachusetts Institute of Technology)
Comparison of the structural organisation of reeler hippocampal CA1 region with wild type CA1.Preprint
Yousuf, M., Zhao, S., & Frotscher, M. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/508648
Ramachandran, P. (2009) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/e8pg-tq46
LincRNAs involved in DCS-induced fear extinction: Shedding light on the transcriptomic dark matterPreprint
Malan‐Müller, S., de Souza, V. B. C., Daniels, W. M. U., Seedat, S., Robinson, M. D., & Hemmings, S. M. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/834242
Exciting inhibition: Local regulation of synapse formation and plasticity
Kruijssen, D. L. H. (2020) · Utrecht University Repository (Utrecht University) · doi:10.33540/296
Higgs, G. V. (2013) · TSpace (University of Toronto)
Hell, J. W. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.5047958.4982062
Representation of Sounds in Auditory Cortex of Awake Rats (Dissertation)Preprint
Hromádka, T., & Hromádka, T. (2008) · Nature Precedings · doi:10.1038/npre.2008.2464 · Cited by 3
Actin and Actin-Binding Proteins: Masters of Dendritic Spine Formation, Morphology, and Function
Lin, W., & Webb, D. J. (2014) · The Open Neuroscience Journal · doi:10.2174/1874082000903010054
Medina, C., Ramos, S. O., Pozzo‐Miller, L. D., Romano, A. G., & de la Fuente, V. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.30.542970
Investigating Binding Partners of the Neuronal Adaptor Protein ShcC Involved in Learning and Memory
Driver, K. R. (2012) · Scholarship@Western (Western University)
Hristovska, I. (2019) · theses.fr (ABES) · doi:10.70675/af1c5105z3e0dz43ffzb906z1553e7a23a6e
Interaction between synaptic and structural plasticity
Camus, C. (2021) · theses.fr (ABES) · doi:10.70675/6340fbbaz26d9z40d5zade8z917b9d9fd531
MORRIS, B. J. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05954-1 · Cited by 1
Korkut, C. (2012) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/vqef-8314
Metadata
- Authors
- Lang, C., Barco, A., Zablow, L., Kandel, E. R., Siegelbaum, S. A., & Zakharenko, S. S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Center for Neurobiology and Behavior, Departments of Pharmacology and Physiology and Biophysics, Kavli Institute for Brain Sciences, and Howard Hughes Medical Institute, Columbia University, 1051 Riverside Drive, New York, NY 10032
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-11-12
- Volume
- 101
- Issue
- 47
- Pages
- 16665-16670
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC534531
- OpenAlex
- W2082900258
- Cited by
- 245
- References
- 34
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 11 · 2019: 16 · 2018: 10 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 16 · 2013: 14 · 2012: 10
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- dendritic spines, long-term potentiation, hippocampus, synaptic plasticity, NMDA receptor, calcium influx, actin polymerization, L-type calcium channels, protein synthesis, synaptic remodeling, adult brain plasticity
- MeSH terms
- Animals, Dendrites, Electric Stimulation, Hippocampus, Mice, Inbred C57BL, Mice, Transgenic, Synaptic Transmission, Recombinant Proteins, Synapses, Long-Term Potentiation, Pyramidal Cells, Calcium Signaling, Calcium Channels, L-Type, Green Fluorescent Proteins, Mice, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
