Cited by 245Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsGenetics and Neurodevelopmental Disorders

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation.

Open access

Lang, Cynthia, Barco, Angel, Zablow, Leonard, Kandel, Eric R., Siegelbaum, Steven A., Zakharenko, Stanislav S.·2004·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0407581101PMC PMC534531

Open this paper in CoChat — free account

Abstract

Dendritic spines are small protrusions from dendritic shafts that contain the postsynaptic sites of glutamatergic synapses in the brain. Spines undergo dramatic activity-dependent structural changes that are particularly prominent during neuronal development. Although changes in spine shape or number have been proposed to contribute to forms of synaptic plasticity that underlie learning and memory, the extent to which spines remain plastic in the adult brain is unclear. We find that induction of long-term potentiation (LTP) of synaptic transmission in acute hippocampal slices of adult mice evokes a reliable, transient expansion in spines that are synaptically activated, as determined with calcium imaging. Similar to LTP, transient spine expansion requires N-methyl-D-aspartate (NMDA) receptor-mediated Ca2+ influx and actin polymerization. Moreover, like the early phase of LTP induced by the stimulation protocol, spine expansion does not require Ca2+ influx through L-type voltage-gated Ca2+ channels nor does it require protein synthesis. Thus, transient spine expansion is a characteristic feature of the initial phases of plasticity at mature synapses and so may contribute to synapse remodeling important for LTP.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.0407581101

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP
Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00084-2 · Cited by 3,042
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
Trachtenberg, J. T., Chen, B. E., Knott, G. W., Feng, G., Sanes, J. R., Welker, E., & Svoboda, K. (2002) · Nature · doi:10.1038/nature01273 · Cited by 1,927
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Engert, F., & Bonhoeffer, T. (1999) · Nature · doi:10.1038/19978 · Cited by 1,412
Morphological Changes in Dendritic Spines Associated with Long-Term Synaptic Plasticity
Yuste, R., & Bonhoeffer, T. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1071 · Cited by 1,269
Structure and function of dendritic spines
Nimchinsky, E. A., Sabatini, B. L., & Svoboda, K. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.160008 · Cited by 1,208
Long-term dendritic spine stability in the adult cortex
Grutzendler, J., Kasthuri, N., & Gan, W.-B. (2002) · Nature · doi:10.1038/nature01276 · Cited by 1,198
Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity
Maletic-Savatic, M., Malinow, R., & Svoboda, K. (1999) · Science · doi:10.1126/science.283.5409.1923 · Cited by 1,009
Dendritic spines as basic functional units of neuronal integration
Yuste, R., & Denk, W. (1995) · Nature · doi:10.1038/375682a0 · Cited by 950
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
Toni, N., Buchs, P.-A., Nikonenko, I., Bron, C. R., & Muller, D. (1999) · Nature · doi:10.1038/46574 · Cited by 949

Flagged first, then by citations

Show all 34 references

Sorted by citations

Items 101–200 of 245

α3-Integrins are required for hippocampal long-term potentiation and working memoryPreprint
Chan, C.-S., Levenson, J. M., Mukhopadhyay, P. S., Zong, L., Bradley, A., Sweatt, J. D., & Davis, R. L. (2007) · Learning & Memory · doi:10.1101/lm.648607 · Cited by 55
Dendritic Spines: The Stuff That Memories Are Made Of?
Hofer, S. B., & Bonhoeffer, T. (2010) · Current Biology · doi:10.1016/j.cub.2009.12.040 · Cited by 63
From synaptic transmission to cognition: An intermediary role for dendritic spines
González‐Burgos, I. (2012) · Brain and Cognition · doi:10.1016/j.bandc.2012.03.002 · Cited by 52
Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term Memory, and Cognitive Flexibility and Alters Dendritic Spine Properties
Nash, A., Aumann, T. D., Pigoni, M., Lichtenthaler, S. F., Takeshima, H., Munro, K. M., & Gunnersen, J. M. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz230 · Cited by 52
Quantification of Dendritic Spines Remodeling under Physiological Stimuli and in Pathological Conditions
Bączyńska, E., Pels, K. K., Basu, S., Włodarczyk, J., & Ruszczycki, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084053 · Cited by 49
In vivo imaging of dendritic spines during electrographic seizures
Rensing, N. R., Ouyang, Y., Yang, X., Yamada, K. A., Rothman, S. M., & Wong, M. L. (2005) · Annals of Neurology · doi:10.1002/ana.20658 · Cited by 51
Rapid Ultrastructural Changes in the PSD and Surrounding Membrane after Induction of Structural LTP in Single Dendritic Spines
Sun, Y., Smirnov, M., Kamasawa, N., & Yasuda, R. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.1964-20.2021 · Cited by 51
Layer‐specific alterations to CA1 dendritic spines in a mouse model of Alzheimer's disease
Merino‐Serrais, P., Knafo, S., Alonso‐Nanclares, L., Fernaud-Espinosa, I., & DeFelipe, J. (2010) · Hippocampus · doi:10.1002/hipo.20861 · Cited by 51
Effects of N-cadherin disruption on spine morphological dynamics
Mysore, S. P. (2007) · Frontiers in Cellular Neuroscience · doi:10.3389/neuro.03.001.2007 · Cited by 55
Structural basis for developmentally regulated changes in cadherin function at synapses
Elste, A. M., & Benson, D. L. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20876 · Cited by 50
Neuropathophysiology of lysosomal storage diseases: synaptic dysfunction as a starting point for disease progression
Pará, C., Bose, P., & Pshezhetsky, A. V. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030616 · Cited by 49
Protracted abstinence from chronic ethanol exposure alters the structure of neurons and expression of oligodendrocytes and myelin in the medial prefrontal cortex
Navarro, A. I., & Mandyam, C. D. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.02.043 · Cited by 47
Encoding, Consolidation, and Renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects
Rantamäki, T., & Kohtala, S. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018697 · Cited by 45
Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Na+/H+ exchanger NHE5
Diering, G. H., Mills, F., Bamji, S. X., & Numata, M. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-01-0066 · Cited by 45
Molecular mechanisms of dendritic spine development and maintenance [Review]
Sala, C., Cambianica, I., & Rossi, F. (2008) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2008-1696 · Cited by 45
Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat
Fox, M. E., Figueiredo, A. M. P. D., Menken, M. S., & Lobo, M. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-69339-7 · Cited by 47
Ultrastructural comparison of dendritic spine morphology preserved with cryo and chemical fixation
Tamada, H., Blanc, J., Korogod, N., Petersen, C. C. H., & Knott, G. W. (2020) · eLife · doi:10.7554/elife.56384 · Cited by 44
Accelerators, Brakes, and Gears of Actin Dynamics in Dendritic Spines
Pontrello, C. G., & Ethell, I. M. (2009) · The Open Neuroscience Journal · doi:10.2174/1874082000903020067 · Cited by 45
Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticity
Greathouse, K. M., Boros, B. D., Deslauriers, J. F., Henderson, B. W., Curtis, K. A., Gentry, E. G., & Herskowitz, J. H. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1748-4 · Cited by 38
Actin and Actin-Binding Proteins: Masters of Dendritic Spine Formation, Morphology, and Function
Lin, W., & Webb, D. J. (2009) · The Open Neuroscience Journal · doi:10.2174/1874082000903020054 · Cited by 42
Opposite effects of glucocorticoid receptor activation on hippocampal CA1 dendritic complexity in chronically stressed and handled animals
Alfarez, D. N., Karst, H., Velzing, E. H., Joëls, M., & Krugers, H. J. (2007) · Hippocampus · doi:10.1002/hipo.20360 · Cited by 39
Systems Biology Perspectives on Cerebellar Long-Term Depression
Ogasawara, H., Doi, T., & Kawato, M. (2008) · Neurosignals · doi:10.1159/000123040 · Cited by 39
Mechanisms and Role of Dendritic Membrane Trafficking for Long-Term Potentiation
Hiester, B. G., Becker, M. I., Bowen, A. B., Schwartz, S. L., & Kennedy, M. J. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00391 · Cited by 37
Imprinting of idyosyncratic experience in cortical sensory maps: Neural substrates of representational remodeling and correlative perceptual changes
Xerri, C. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.038 · Cited by 38
Methylphenidate Restores Behavioral and Neuroplasticity Impairments in the Prenatal Nicotine Exposure Mouse Model of ADHD: Evidence for Involvement of AMPA Receptor Subunit Composition and Synaptic Spine Morphology in the Hippocampus
Contreras, D., Piña, R., Carvallo, C., Godoy, F., Ugarte, G., Zeise, M., Rozas, C., & Morales, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137099 · Cited by 35
Neurologic links between epilepsy and depression in women
Hajszán, T., & MacLusky, N. J. (2006) · Neurology · doi:10.1212/wnl.66.66_suppl_3.s13 · Cited by 35
Increased AMPA receptor GluR1 subunit incorporation in rat hippocampal CA1 synapses during benzodiazepine withdrawal
Das, P., Lilly, S. M., Zerda, R., Gunning, W. T., Álvarez, F. J., & Tietz, E. I. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21866 · Cited by 36
GABAA receptor drugs and neuronal plasticity in reward and aversion: focus on the ventral tegmental area
Vashchinkina, E., Panhelainen, A. E., Aitta‐aho, T., & Korpi, E. R. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00256 · Cited by 38
Changes in the plastic properties of hippocampal dendritic spines underlie the attenuation of place learning in healthy aged rats
González-Ramírez, M. M., Velázquez-Zamora, D. A., Olvera‐Cortés, M. E., & González‐Burgos, I. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.017 · Cited by 32
Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders
Barrantes, F. J. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1476909 · Cited by 37
PKMζ is necessary and sufficient for synaptic clustering of PSD‐95
Shao, C., Sondhi, R., van de Nes, P. S., & Sacktor, T. C. (2011) · Hippocampus · doi:10.1002/hipo.20996 · Cited by 29
Stabilizing dendritic structure as a novel therapeutic approach for epilepsy
Wong, M. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.6.907 · Cited by 29
Exposure to RF-EMF Alters Postsynaptic Structure and Hinders Neurite Outgrowth in Developing Hippocampal Neurons of Early Postnatal Mice
Kim, J. H., Chung, K. H., Hwang, Y. R., Park, H. R., Kim, H. J., Kim, H.-G., & Kim, H. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105340 · Cited by 28
Long-Term Potentiation in Isolated Dendritic Spines
Corera, A. T., Doucet, G., & Fon, E. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006021 · Cited by 30
A Synaptic Function Approach to Investigating Complex Psychiatric Diseases
Earls, L. R., & Zakharenko, S. S. (2013) · The Neuroscientist · doi:10.1177/1073858413498307 · Cited by 28
Self-citation
Molecular Studies of Learning and Memory in Aplysia and the Hippocampus: A Comparative Analysis of Implicit and Explicit Memory Storage
Bailey, C. H., Barco, Á., Hawkins, R. D., & Kandel, E. R. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00191-1 · Cited by 28
Self-citation
Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiation
Hussain, R. J., Stumpo, D. J., Blackshear, P. J., Lenox, R. H., Abel, T. G., & McNamara, R. K. (2006) · Hippocampus · doi:10.1002/hipo.20177 · Cited by 27
Nicotine induces dendritic spine remodeling in cultured hippocampal neurons
Oda, A., Yamagata, K., Nakagomi, S., Uejima, H., Wiriyasermkul, P., Ohgaki, R., Nagamori, S., Kanai, Y., & Tanaka, H. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12470 · Cited by 27
Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats
Arias‐Cavieres, A., More, J., Vicente, J. M., Adasme, T., Hidalgo, J., Valdés, J. L., Humeres, A., Valdés-Undurraga, I., Sánchez, G., Hidalgo, C., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00429 · Cited by 27
Spine Modifications Associated with Long-Term Potentiation
Yang, Y., & Zhou, Q. (2009) · The Neuroscientist · doi:10.1177/1073858409340800 · Cited by 30
Exercise and the Brain: Neurogenesis, Synaptic Plasticity, Spine Density, and Angiogenesis
Wang, Z., & van Praag, H. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3293-7_1 · Cited by 31
Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP
Cho, E., Kim, D., Hur, Y.-N., Whitcomb, D. J., Regan, P. L., Hong, J.-H., Kim, H., Suh, Y. H., Cho, K., & Park, M. (2015) · Scientific Reports · doi:10.1038/srep12624 · Cited by 25
The effects of gonadal hormones on learning and memory in male mammals: A review
Leonard, S. T., & Winsauer, P. J. (2011) · Current Zoology · doi:10.1093/czoolo/57.4.543 · Cited by 26
Chronic Metabolic Derangement-Induced Cognitive Deficits and Neurotoxicity Are Associated with REST Inactivation
Remor, A. P., da Silva, R. A., Matos, F., Glaser, V., Martins, R. D. P., Ghisoni, K., Scheffer, D. D. L., Andia, D. C., Portinho, D., de Souza, A. P., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1175-9 · Cited by 24
Intrinsic Spine Dynamics Are Critical for Recurrent Network Learning in Models With and Without Autism Spectrum Disorder
Humble, J., Hiratsuka, K., Kasai, H., & Toyoizumi, T. (2019) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2019.00038 · Cited by 23
Glutamate-dependent translational regulation in cultured Bergmann glia cells: involvement of p70S6K.
Gonzalez-Mejia, M., Morales, M., Hernández-Kelly, L. C., Zepeda, R. C., Bernabé, A., & Ortega, A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.076 · Cited by 25
Activation of α7 nicotinic acetylcholine receptors protects potentiated synapses from depotentiation during theta pattern stimulation in the hippocampal CA1 region of rats
Galvez, B., Gross, N. B., & Sumikawa, K. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.02.008 · Cited by 23
Single Synapse LTP: A Matter of Context?
Kruijssen, D. L. H., & Wierenga, C. J. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00496 · Cited by 26
Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition
Kasai, H. (2023) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.99.018 · Cited by 25
Selective activation of BK channels in small‐headed dendritic spines suppresses excitatory postsynaptic potentials
Tazerart, S., Blanchard, M. G., Miranda‐Rottmann, S., Mitchell, D. E., Pina, B. N., Thomas, C. I., Kamasawa, N., & Araya, R. (2022) · The Journal of Physiology · doi:10.1113/jp282303 · Cited by 22
Sex differences in dendritic spine density and morphology in auditory and visual cortices in adolescence and adulthood
Parker, E. M., Kindja, N. L., Cheetham, C. E. J., & Sweet, R. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-65942-w · Cited by 23
Glucagon-Like Peptide-1 Cleavage Product Improves Cognitive Function in a Mouse Model of Down Syndrome
Day, S. M., Yang, W., Wang, X., Stern, J. E., Zhou, X., Macauley, S. L., & Ma, T. (2019) · eNeuro · doi:10.1523/eneuro.0031-19.2019 · Cited by 21
The motor learning induces plastic changes in dendritic spines of Purkinje cells from the neocerebellar cortex of the rat
González-Tapia, D., Velázquez-Zamora, D. A., Olvera‐Cortés, M. E., & González‐Burgos, I. (2015) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-140462 · Cited by 20
Hippocampal seizures cause depolymerization of filamentous actin in neurons independent of acute morphological changes
Ouyang, Y., Yang, X., Hu, X. Y., Altay, E. E., Zeng, L., Lee, J., & Wong, M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.077 · Cited by 21
Pentylenetetrazol-induced seizures in adult rats are associated with plastic changes to the dendritic spines on hippocampal CA1 pyramidal neurons
Flores-Soto, M. E., Romero-Guerrero, C., Vázquez-Hernández, N., Tejeda-Martínez, A. R., Martín-Amaya-Barajas, F. L., Orozco-Suárez, S. A., & González‐Burgos, I. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113198 · Cited by 20
Computational roles of intrinsic synaptic dynamics
Shimizu, G., Yoshida, K., Kasai, H., & Toyoizumi, T. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.06.002 · Cited by 17
Changes of Dendritic Spine Density and Morphology in the Superficial Layers of the Medial Entorhinal Cortex Induced by Extremely Low-Frequency Magnetic Field Exposure
Xiong, J., He, C., Li, C., Tan, G., Li, J., Yu, Z., Hu, Z., & Chen, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083561 · Cited by 18
Epigenetic modifications induced by exercise: Drug-free intervention to improve cognitive deficits associated with obesity
Barros, L., Eichwald, T., Solano, A. F., Scheffer, D. D. L., da Silva, R. A., Gaspar, J. M., & Latini, A. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.03.009 · Cited by 18
Conditional deletion of Neurexin-2 alters neuronal network activity in hippocampal circuitries and leads to spontaneous seizures
Haile, M. T., Khoja, S., de Carvalho, G., Hunt, R. F., & Chen, L. Y. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02394-6 · Cited by 18
Environmental Enrichment in Murine Models and Its Translation to Human Factors Improving Conditions in Alzheimer Disease
Colavitta, M. F., Grasso, L., & Barrantes, F. J. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.5 · Cited by 15
Spine Remodeling and Synaptic Modification
Wang, X., & Zhou, Q. (2010) · Molecular Neurobiology · doi:10.1007/s12035-009-8093-9 · Cited by 18
Effects of Different Levels of Food Restriction on Passive-Avoidance Memory and The Expression of Synapsin I in Young Mice
Deng, L., Wu, Z., & Han, P.-Z. (2009) · International Journal of Neuroscience · doi:10.1080/00207450802328250 · Cited by 15
Early growth response‐1‐mediated down‐regulation of drebrin correlates with loss of dendritic spines
Cho, C., MacDonald, R., Shang, J., Cho, M. J., Chalifour, L. E., & Paudel, H. K. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14031 · Cited by 15
Age-dependent glutamate induction of synaptic plasticity in cultured hippocampal neuronsPreprint
Sapoznik, S., Ivenshitz, M., & Segal, M. (2006) · Learning & Memory · doi:10.1101/lm.351706 · Cited by 16
Impact of distinct neurotransmitter release modes on neuronal signaling
Zhang, K. J., Monteggia, L. M., & Kavalali, E. T. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03373-7 · Cited by 22
Serotonin Induces Structural Plasticity of Both Extrinsic Modulating and Intrinsic Mediating Circuits In Vitro in Aplysia Californica
Upreti, C., Konstantinov, E., Kassabov, S. R., Bailey, C. H., & Kandel, E. R. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.016 · Cited by 13
Self-citation
Activity-Dependent Structural Plasticity of Dendritic Spines
Chapleau, C. A., & Pozzo‐Miller, L. D. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00039-5 · Cited by 14
Network, Cellular, and Molecular Mechanisms Underlying Long-Term Memory Formation
Carasatorre, M., & Ramı́rez-Amaya, V. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_229 · Cited by 14
Nanoscale Sub-Compartmentalization of the Dendritic Spine Compartment
Vallés, A. S., & Barrantes, F. J. (2021) · Biomolecules · doi:10.3390/biom11111697 · Cited by 14
miR-483-5p offsets functional and behavioural effects of stress in male mice through synapse-targeted repression of Pgap2 in the basolateral amygdala
Mucha, M. W., Skrzypiec, A. E., Kolenchery, J. B., Brambilla, V., Patel, S., Labrador-Ramos, A., Kudla, L., Murrall, K., Skene, N., Dymicka-Piekarska, V., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37688-2 · Cited by 14
Probing Single Synapses via the Photolytic Release of Neurotransmitters
Mitchell, D. E., Martineau, É., Tazerart, S., & Araya, R. (2019) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2019.00019 · Cited by 13
CREB-Dependent Transcription and Synaptic Plasticity
Barco, Á., Jančić, D., & Kandel, E. R. (2007) · Springer eBooks · doi:10.1007/978-0-387-73609-9_7 · Cited by 12
Self-citation
A unifying mechanism for presynaptic homeostatic plasticity at mammalian peripheral and central synapses
Chipman, P. H., Lee, U., Orr, B. O., Fetter, R. D., & Davis, G. W. (2025) · Neuron · doi:10.1016/j.neuron.2025.05.030 · Cited by 12
Dendritic Spines and Pain Memory
Benson, C. A., King, J. F., Reimer, M. L., Kauer, S. D., Waxman, S. G., & Tan, A. M. (2022) · The Neuroscientist · doi:10.1177/10738584221138251 · Cited by 13
MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo
Kelly-Castro, E. C., Shear, R., Dindigal, A. H., Bhagwat, M., & Zhang, H. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114752 · Cited by 10
Engram formation in psychiatric disorders
Gebicke‐Haerter, P. J. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00118 · Cited by 12
Expression and characterization of a brain-specific protein kinase BSK146 from zebrafish
Chou, C., Chen, Y., Lee, M., Chen, G.-D., Lu, I.-C., Chen, S., & Huang, C. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.090 · Cited by 10
Shedding Light on the Transcriptomic Dark Matter in Biological Psychiatry: Role of Long Noncoding RNAs in D-cycloserine-Induced Fear Extinction in Posttraumatic Stress Disorder
Malan‐Müller, S., de Souza, V. B. C., Daniels, W. M. U., Seedat, S., Robinson, M. D., & Hemmings, S. M. J. (2020) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2020.0031 · Cited by 9
Superresolving dendritic spine morphology with STED microscopy under holographic photostimulation
Lauterbach, M. A., Guillon, M., Desnos, C., Khamsing, D., Jaffal, Z., Darchen, F., & Emiliani, V. (2016) · Neurophotonics · doi:10.1117/1.nph.3.4.041806 · Cited by 9
A potential mechanism for first-person internal sensation of memory provides evidence for the relationship between learning and LTP induction
Vadakkan, K. I. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.038 · Cited by 9
Synaptic Mechanisms of Activity-Dependent Remodeling in Visual Cortex during Monocular Deprivation
Rittenhouse, C. D., & Majewska, A. K. (2009) · Journal of Experimental Neuroscience · doi:10.4137/jen.s2559 · Cited by 9
Plastic changes to dendritic spines in the cerebellar and prefrontal cortices underlie the decline in motor coordination and working memory during successful aging
Vázquez-Hernández, N., Martínez-Torres, N. I., & González‐Burgos, I. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113014 · Cited by 7
Correlative Ultrastructural Analysis of Functionally Modulated Synapses Using Automatic Tape-Collecting Ultramicrotome - SEM Array Tomography
Kamasawa, N., Sun, Y., Mikuni, T., Guerrero‐Given, D., & Yasuda, R. (2015) · Microscopy and Microanalysis · doi:10.1017/s143192761500714x · Cited by 6
Dendrites: A Key Structural Element of Neurons
Rollenhagen, A., & Lübke, J. H. R. (2012) · Springer eBooks · doi:10.1007/978-1-4614-1997-6_11 · Cited by 7
A Comparative Analysis of the Molecular Mechanisms Contributing to Implicit and Explicit Memory Storage in Aplysia and in the Hippocampus ☆
Hawkins, R. D., Mayford, M. R., & Kandel, E. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21095-x · Cited by 6
Self-citation
Integrins and Cadherins – Extracellular Matrix in Memory Formation
Chan, C.-S., & Davis, R. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00040-1 · Cited by 6
Design of Ultrapotent Genetically Encoded Inhibitors of Kv4.2 for Gating Neural Plasticity
Andreyanov, M., Heinrich, R., & Berlin, S. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2295-22.2023 · Cited by 4
Mapping Divergent Subfield‐Specific Hippocampal Degeneration in Mild Cognitive Impairment Continuum: Volumetric, Cognitive, and Genetic Predictors of Accelerated Hippocampal Biological Aging
Ghaderi, S., Mohammadi, S., Fatehi, F., & Initiative, A. D. N. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70548 · Cited by 3
Dendritic Elaboration: Morphology and Chemistry
Rollenhagen, A., & Lübke, J. H. R. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3474-4_11 · Cited by 4
The Molecular Basis of Destabilization of Synapses as a Factor of Structural Plasticity
Kudryashova, I. V. (2019) · Neurochemical Journal · doi:10.1134/s1819712419010136 · Cited by 4
The Reorganization of the Actin Matrix as a Factor of Presynaptic Plasticity
Kudryashova, I. V. (2021) · Neurochemical Journal · doi:10.1134/s1819712421030089 · Cited by 4
Rapid Ultrastructural Changes of PSD and Extrasynaptic Axon-spine Interface Membrane during LTP Induced in Single Dendritic SpinePreprint
Sun, Y., Smirnov, M., Kamasawa, N., & Yasuda, R. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/840629 · Cited by 4
A hyperexcited basolateral amygdala complex state determines the hippocampal structural plasticity associated with the reconsolidation of a fear memory
Sosa, M. C., Mutis, R. C., Gargiulo, M. R., Martijena, I. D., Bender, C. L., & Calfa, G. D. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.11.023 · Cited by 3
Abstinence and Fear Experienced during This Period Produce Distinct Cortical and Hippocampal Adaptations in Alcohol-Dependent Rats
Steiner, N. L., Purohit, D. C., Tiefenthaler, C. M., & Mandyam, C. D. (2024) · Brain Sciences · doi:10.3390/brainsci14050431 · Cited by 3
Structural Plasticity and Cortical Connectivity
Kehayas, V., & Holtmaat, A. J. D. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803784-3.00001-9 · Cited by 3
Synaptic and Cellular Basis of Learning
Bailey, C. H., & Kandel, E. R. (2009) · Wiley eBooks · doi:10.1002/9780470478509.neubb001028 · Cited by 3
Self-citation
Correlative Ultrastructural Analysis of Functionally Modulated Synapses Using Automated Tape-Collecting Ultramicrotome and SEM Array Tomography
Sun, Y., Thomas, C. I., Mikuni, T., Guerrero‐Given, D., Yasuda, R., & Kamasawa, N. (2020) · Neuromethods · doi:10.1007/978-1-0716-0691-9_7 · Cited by 2
AMPA receptors in synaptic plasticity and learning and memory
Kim, K., & Park, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00056-0 · Cited by 1
GAL-201 as a Promising Amyloid-β-Targeting Small-Molecule Approach for Alzheimer’s Disease Treatment: Consistent Effects on Synaptic Plasticity, Behavior and Neuroinflammation
Riemann, K., von Ahsen, J., Böhm, T., Schlegel, M., Kreuzer, M., Fenzl, T., Russ, H., Parsons, C. G., & Rammes, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094167 · Cited by 1
Microglial Cells Function in the Central Nervous System
El‐Mansoury, B., Smimih, K., Hamdan, Y. A., Draoui, A., Boulbaroud, S., & Jayakumar, A. R. (2023) · Advances in bioinformatics and biomedical engineering book series · doi:10.4018/978-1-6684-9675-6.ch004 · Cited by 1

Authors: Lang, C., Barco, A., Zablow, L., Kandel, E. R., Siegelbaum, S. A., & Zakharenko, S. S.
Affiliations: Howard Hughes Medical Institute (US)
Center for Neurobiology and Behavior, Departments of Pharmacology and Physiology and Biophysics, Kavli Institute for Brain Sciences, and Howard Hughes Medical Institute, Columbia University, 1051 Riverside Drive, New York, NY 10032
ORCID: Kandel, Eric R.
Siegelbaum, Steven A.
Zakharenko, Stanislav S.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2004-11-12
Volume: 101
Issue: 47
Pages: 16665-16670
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0407581101
PMC: PMC534531
OpenAlex: W2082900258
Cited by: 245
References: 34
Citations by year: 2026: 2 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 11 · 2019: 16 · 2018: 10 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 16 · 2013: 14 · 2012: 10
FWCI: 5.52
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: dendritic spines, long-term potentiation, hippocampus, synaptic plasticity, NMDA receptor, calcium influx, actin polymerization, L-type calcium channels, protein synthesis, synaptic remodeling, adult brain plasticity
MeSH terms: Animals, Dendrites, Electric Stimulation, Hippocampus, Mice, Inbred C57BL, Mice, Transgenic, Synaptic Transmission, Recombinant Proteins, Synapses, Long-Term Potentiation, Pyramidal Cells, Calcium Signaling, Calcium Channels, L-Type, Green Fluorescent Proteins, Mice, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks