Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice
Open accessAbstract
The Scar/WAVE family of scaffolding proteins organize molecular networks that relay signals from the GTPase Rac to the actin cytoskeleton. The WAVE-1 isoform is a brain-specific protein expressed in variety of areas including the regions of the hippocampus and the Purkinje cells of the cerebellum. Targeted disruption of the WAVE-1 gene generated mice with reduced anxiety, sensorimotor retardation, and deficits in hippocampal-dependent learning and memory. These sensorimotor and cognitive deficits are analogous to the symptoms of patients with 3p-syndrome mental retardation who are haploinsufficient for WRP/MEGAP, a component of the WAVE-1 signaling network. Thus WAVE-1 is required for normal neural functioning.
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WAVE1 is a brain-enriched regulator that is especially abundant in neurons, oligodendrocyte precursor cells and mature oligodendrocytes.
“WAVE1 is a brain-enriched regulator that is especially abundant in neurons9–12, oligodendrocyte precursor cells and mature oligodendrocytes13.”
From The WAVE complex in developmental and adulthood brain disorders (2025) · cites this paper as [10]
The loss of WAVE1 results in sensorimotor retardation and diminished learning and memory abilities in mice.
“The loss of WAVE1 results in sensorimotor retardation and diminished learning and memory abilities in mice10.”
From The WAVE complex in developmental and adulthood brain disorders (2025) · cites this paper as [10]
The three truncated variants are associated with a similar phenotype as that observed in Wasf1 KO mice.
“Notably, the three truncated variants are associated with a similar phenotype as that observed in Wasf1 KO mice10.”
From The WAVE complex in developmental and adulthood brain disorders (2025) · cites this paper as [10]
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The WAVE complex in developmental and adulthood brain disorders
Kim, H.-G., Berdasco, C., Nairn, A. C., & Kim, Y. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01386-w · Cited by 8 · see citing works
- Authors
- Soderling, S. H., Langeberg, L. K., Soderling, J. A., Davee, S. M., Simerly, R., Raber, J., & Scott, J. D.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Scott, John D.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2003-02-10
- Volume
- 100
- Issue
- 4
- Pages
- 1723-1728
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC149900
- OpenAlex
- W2168634382
- Cited by
- 202
- References
- 4
- Citations by year
- 2026: 3 · 2025: 3 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 10 · 2012: 12
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DK44239)
- National Institute on Aging (AG20079)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK044239, DK44239)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Keywords
- Rac GTPase, actin cytoskeleton, hippocampus, Purkinje cells, learning and memory impairment, anxiety, haploinsufficiency, knockout mice, cognitive impairment
- MeSH terms
- Animals, Cloning, Molecular, Immunohistochemistry, Learning, Memory, Mice, Inbred C57BL, Microfilament Proteins, Motor Activity, Blotting, Southern, Blotting, Northern, Polymerase Chain Reaction, In Situ Hybridization, Mice, Knockout, Chromosomes, Artificial, Bacterial, Wiskott-Aldrich Syndrome Protein Family, Mice
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