Control of dendritic spine morphological and functional plasticity by small GTPases.
Open accessAbstract
Structural plasticity of excitatory synapses is a vital component of neuronal development, synaptic plasticity, and behaviour. Abnormal development or regulation of excitatory synapses has also been strongly implicated in many neurodevelopmental, psychiatric, and neurodegenerative disorders. In the mammalian forebrain, the majority of excitatory synapses are located on dendritic spines, specialized dendritic protrusions that are enriched in actin. Research over recent years has begun to unravel the complexities involved in the regulation of dendritic spine structure. The small GTPase family of proteins have emerged as key regulators of structural plasticity, linking extracellular signals with the modulation of dendritic spines, which potentially underlies their ability to influence cognition. Here we review a number of studies that examine how small GTPases are activated and regulated in neurons and furthermore how they can impact actin dynamics, and thus dendritic spine morphology. Elucidating this signalling process is critical for furthering our understanding of the basic mechanisms by which information is encoded in neural circuits but may also provide insight into novel targets for the development of effective therapies to treat cognitive dysfunction seen in a range of neurological disorders.
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Rac1 and Rap1 are important for spine enlargement and dynamics, respectively.
“These observations are consistent with the current knowledge on Rac1 and Rap1, which are important for spine enlargement and dynamics, respectively (Woolfrey and Srivastava, 2016).”
From Two Autism/Dyslexia Linked Variations of DOCK4 Disrupt the Gene Function on Rac1/Rap1 Activation, Neurite Outgrowth, and Synapse Development (2020) · cites this paper as Woolfrey and Srivastava, 2016
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Cites
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works
Takai, Y., Sasaki, T., & Matozaki, T. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.153 · Cited by 2,466 · see citing works
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376 · see citing works
Experience-dependent structural synaptic plasticity in the mammalian brain
Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934 · see citing works
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
Trachtenberg, J. T., Chen, B. E., Knott, G. W., Feng, G., Sanes, J. R., Welker, E., & Svoboda, K. (2002) · Nature · doi:10.1038/nature01273 · Cited by 1,927 · see citing works
Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase
Maekawa, M., Ishizaki, T., Boku, S., Watanabe, N., Fujita, A., Iwamatsu, A., Obinata, T., Ohashi, K., Mizuno, K., & Narumiya, S. (1999) · Science · doi:10.1126/science.285.5429.895 · Cited by 1,640 · see citing works
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636 · see citing works
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · cited 1× · see citing works
“For example, large dendritic spines are likely to feature large PSDs and make strong connections, while small dendritic spines are indicative of weak connections and may be highly plastic [16].”
BackgroundA brain serine/threonine protein kinase activated by Cdc42 and Rac1
Manser, E. J., Leung, T., Salihuddin, H., Zhao, Z.-S., & Lim, L. (1994) · Nature · doi:10.1038/367040a0 · Cited by 1,541 · see citing works
Dendritic spine pathology in neuropsychiatric disorders
Penzes, P., Cahill, M. E., Jones, K. A., VanLeeuwen, J.-E., & Woolfrey, K. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2741 · Cited by 1,523 · see citing works
Self-citationNormal development of brain circuits
Tau, G. Z., & Peterson, B. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.115 · Cited by 1,391 · see citing works
Regulation of Small GTPases by GEFs, GAPs, and GDIs
Cherfils, J., & Zeghouf, M. (2013) · Physiological Reviews · doi:10.1152/physrev.00003.2012 · Cited by 1,245 · see citing works
Stably maintained dendritic spines are associated with lifelong memories
Yang, G., Pan, F., & Gan, W.-B. (2009) · Nature · doi:10.1038/nature08577 · Cited by 1,182 · see citing works
Transient and persistent dendritic spines in the neocortex in vivo
Holtmaat, A. J. G. D., Trachtenberg, J. T., Wilbrecht, L., Shepherd, G. M., Zhang, X., Knott, G. W., & Svoboda, K. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.003 · Cited by 1,131 · see citing works
The ARP2/3 complex: an actin nucleator comes of age
Goley, E. D., & Welch, M. D. (2006) · Nature reviews. Molecular cell biology · doi:10.1038/nrm2026 · Cited by 1,106 · see citing works
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
Edwards, D. C., Sanders, L. C., Bokoch, G., & Gill, G. N. (1999) · Nature Cell Biology · doi:10.1038/12963 · Cited by 1,065 · see citing works
The WASP-WAVE protein network: Connecting the membrane to the cytoskeleton.
Takenawa, T., & Suetsugu, S. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2069 · Cited by 947 · see citing works
Rapid Actin-Based Plasticity in Dendritic Spines
Fischer, M., Kaech, S., Knutti, D., & Matus, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80467-5 · Cited by 905 · see citing works
Actin-based plasticity in dendritic spines
Matus, A. (2000) · Science · doi:10.1126/science.290.5492.754 · Cited by 815 · see citing works
Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?
Fiala, J. C., Spacek, J., & Harris, K. M. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00158-3 · Cited by 811 · see citing works
Structural dynamics of dendritic spines in memory and cognition
Kasai, H., Fukuda, M., Watanabe, S., Hayashi-Takagi, A., & Noguchi, J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.01.001 · Cited by 804 · see citing works
Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders
Hutsler, J. J., & Zhang, H. (2010) · Brain Research · doi:10.1016/j.brainres.2009.09.120 · Cited by 765 · see citing works
Autoinhibition and activation mechanisms of the Wiskott–Aldrich syndrome protein
Kim, A. S., Kakalis, L. T., Abdul-Manan, N., Liu, G. A., & Rosen, M. K. (2000) · Nature · doi:10.1038/35004513 · Cited by 752 · see citing works
Cortical rewiring and information storage
Chklovskii, D. B., Mel, B. W., & Svoboda, K. (2004) · Nature · doi:10.1038/nature03012 · Cited by 717 · see citing works
Nakayama, A. Y., Harms, M. B., & Luo, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05329.2000 · Cited by 708 · see citing works
Postnatal neurodevelopmental disorders: meeting at the synapse?
Zoghbi, H. Y. (2003) · Science · doi:10.1126/science.1089071 · Cited by 691 · see citing works
Abnormal Spine Morphology and Enhanced LTP in LIMK-1 Knockout Mice
Meng, Y., Zhang, Y., Tregoubov, V., Janus, C., Cruz, L., Jackson, M., Lu, W.-Y., MacDonald, J. F., Wang, J. Y., Falls, D. L., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00758-4 · Cited by 688 · see citing works
Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation
Bosch, M., Castro, J., Saneyoshi, T., Matsuno, H., Sur, M., & Hayashi, Y. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.021 · Cited by 637 · see citing works
Dendritic Spine Structural Anomalies in Fragile-X Mental Retardation Syndrome
Irwin, S. A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.1038 · Cited by 626 · see citing works
Molecular mechanisms of dendritic spine morphogenesis
Tada, T., & Sheng, M. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.12.001 · Cited by 615 · see citing works
Protein palmitoylation in neuronal development and synaptic plasticity
Fukata, Y., & Fukata, M. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2788 · Cited by 614 · see citing works
Local, persistent activation of Rho GTPases during plasticity of single dendritic spines
Murakoshi, H., Wang, H., & Yasuda, R. (2011) · Nature · doi:10.1038/nature09823 · Cited by 564 · see citing works
Égile, C., Loisel, T. P., Laurent, V., Li, R., Pantaloni, D., Sansonetti, P. J., & Carlier, M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.6.1319 · Cited by 523 · see citing works
Ca2+/CaM-Dependent Kinases: From Activation to Function
Hook, S. S., & Means, A. R. (2001) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.471 · Cited by 482 · see citing works
Bos, J. L. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.009 · Cited by 481 · see citing works
Mandai, K., Nakanishi, H., Satoh, A., Obaishi, H., Wada, M., Nishioka, H., Itoh, M., Mizoguchi, A., Aoki, T., Fujimoto, T., et al. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.2.517 · Cited by 476 · see citing works
Penzes, P., Beeser, A., Chernoff, J., Schiller, M. R., Eipper, B. A., Mains, R. E., & Huganir, R. L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01168-6 · Cited by 466 · see citing works
Rapid turnover of actin in dendritic spines and its regulation by activity
Star, E. N., Kwiatkowski, D. J., & Murthy, V. N. (2002) · Nature Neuroscience · doi:10.1038/nn811 · Cited by 465 · see citing works
Dendritic Spines: The Locus of Structural and Functional Plasticity
Sala, C., & Segal, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00012.2013 · Cited by 465 · see citing works
Spine neck plasticity regulates compartmentalization of synapses
Tønnesen, J., Katona, G., Rózsa, B., & Nägerl, U. V. (2014) · Nature Neuroscience · doi:10.1038/nn.3682 · Cited by 444 · see citing works
The Spread of Ras Activity Triggered by Activation of a Single Dendritic Spine
Harvey, C. D., Yasuda, R., Zhong, H., & Svoboda, K. (2008) · Science · doi:10.1126/science.1159675 · Cited by 434 · see citing works
Ultrastructure of Synapses in the Mammalian BrainPreprint
Harris, K. M., & Weinberg, R. J. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005587 · Cited by 423 · see citing works
Tashiro, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.927 · Cited by 416 · see citing works
Impermanence of dendritic spines in live adult CA1 hippocampus
Attardo, A., Fitzgerald, J. E., & Schnitzer, M. J. (2015) · Nature · doi:10.1038/nature14467 · Cited by 399 · see citing works
Akil, M., Pierri, J. N., Whitehead, R. E., Edgar, C. L., Mohila, C., Sampson, A. R., & Lewis, D. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.10.1580 · Cited by 393 · see citing works
Clement, J. P., Aceti, M., Creson, T. K., Ozkan, E. D., Shi, Y., Reish, N. J., Almonte, A. G., Miller, B. H., Wiltgen, B. J., Miller, C. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.045 · Cited by 385 · see citing works
Bhatt, D. H., Zhang, S., & Gan, W.-B. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163140 · Cited by 380 · see citing works
Kalirin-7 Controls Activity-Dependent Structural and Functional Plasticity of Dendritic Spines
Xie, Z., Srivastava, D. P., Photowala, H., Kai, L., Cahill, M. E., Woolfrey, K. M., Shum, C. Y., Surmeier, D. J., & Penzes, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.005 · Cited by 373 · see citing works
Self-citationGlutamate induces de novo growth of functional spines in developing cortex
Kwon, H.-B., & Sabatini, B. L. (2011) · Nature · doi:10.1038/nature09986 · Cited by 368 · see citing works
Tolias, K. F., Bikoff, J. B., Burette, A., Paradis, S., Harrar, D., Tavazoie, S., Weinberg, R. J., & Greenberg, M. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.024 · Cited by 365 · see citing works
Hotulainen, P., Llano, O., Smirnov, S., Tanhuanpää, K., Faix, J., Rivera, C., & Lappalainen, P. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200809046 · Cited by 360 · see citing works
Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance.
Liston, C., Cichon, J. M., Jeanneteau, F., Jia, Z., Chao, M. V., & Gan, W.-B. (2013) · Nature Neuroscience · doi:10.1038/nn.3387 · Cited by 358 · see citing works
A GIT1/PIX/Rac/PAK Signaling Module Regulates Spine Morphogenesis and Synapse Formation through MLC
Zhang, H., Webb, D. J., Asmussen, H., Niu, S., & Horwitz, A. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3553-04.2005 · Cited by 354 · see citing works
Synapse Pathology in Psychiatric and Neurologic Disease
van Spronsen, M., & Hoogenraad, C. C. (2010) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-010-0104-8 · Cited by 345 · see citing works
ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity
Gu, J., Lee, C. W., Fan, Y., Komlos, D., Tang, X., Sun, C., Yu, K., Hartzell, H. C., Chen, G., Bamburg, J. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2634 · Cited by 325 · see citing works
Experience-dependent structural plasticity in the cortex
Fu, M., & Zuo, Y. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.02.001 · Cited by 322 · see citing works
Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
Fu, W., Chen, Y., Şahin, M., Zhao, X.-S., Shi, L., Bikoff, J. B., Lai, K., Yung, W., Fu, A. K. Y., Greenberg, M. E., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1811 · Cited by 311 · see citing works
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology
Kim, Y., Sung, J. Y., Ceglia, I., Lee, K.-W., Ahn, J.-H., Halford, J. M., Kim, A. M., Kwak, S. P., Park, J. B., Ho Ryu, S., et al. (2006) · Nature · doi:10.1038/nature04976 · Cited by 307 · see citing works
Dendritic spines and distributed circuits
Yuste, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.024 · Cited by 298 · see citing works
The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis
Govek, E.-E., Newey, S. E., Akerman, C. J., Cross, J. R., Van der Veken, L., & Van Aelst, L. (2004) · Nature Neuroscience · doi:10.1038/nn1210 · Cited by 293 · see citing works
PAK and other Rho-associated kinases – effectors with surprisingly diverse mechanisms of regulation
Zhao, Z.-S., & Manser, E. (2005) · Biochemical Journal · doi:10.1042/bj20041638 · Cited by 292 · see citing works
Dendritic spine formation and stabilization
Yoshihara, Y., De Roo, M., & Muller, D. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.013 · Cited by 292 · see citing works
Hayashi, M. L., Choi, S.-Y., Rao, B. S. S., Jung, H.-Y., Lee, H.-K., Zhang, D., Chattarji, S., Kirkwood, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.003 · Cited by 280 · see citing works
Araki, Y., Zeng, M., Zhang, M., & Huganir, R. L. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.023 · Cited by 271 · see citing works
Frost, N. A., Shroff, H., Kong, H., Betzig, E., & Blanpied, T. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.026 · Cited by 263 · see citing works
Tashiro, A., & Yuste, R. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.04.001 · Cited by 253 · see citing works
Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors
Arthur, W. T., Quilliam, L. A., & Cooper, J. A. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200404068 · Cited by 252 · see citing works
Pathology of Layer V Pyramidal Neurons in the Prefrontal Cortex of Patients With Schizophrenia
Black, J. E., Kodish, I. M., Grossman, A. W., Klintsova, A. Y., Orlovskaya, D., Vostrikov, V., Uranova, N., & Greenough, W. T. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.4.742 · Cited by 250 · see citing works
Lewis, D. A., & Sweet, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37335 · Cited by 235 · see citing works
Wegner, A. M., Nebhan, C. A., Hu, L., Majumdar, D., Meier, K. M., Weaver, A. M., & Webb, D. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801555200 · Cited by 232 · see citing works
CaM-kinases: modulators of synaptic plasticity
Soderling, T. R. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00090-8 · Cited by 231 · see citing works
Hill, J. J., Hashimoto, T., & Lewis, D. A. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001792 · Cited by 228 · see citing works
Jones, K. A., Srivastava, D. P., Allen, J. A., Strachan, R. T., Roth, B. L., & Penzes, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905884106 · Cited by 226 · see citing works
Self-citationA WAVE-1 and WRP Signaling Complex Regulates Spine Density, Synaptic Plasticity, and Memory
Soderling, S. H., Guire, E. S., Kaech, S., White, J., Zhang, F., Schutz, K., Langeberg, L. K., Banker, G., Raber, J., & Scott, J. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3209-06.2006 · Cited by 217 · see citing works
Cofilin Dissociates Arp2/3 Complex and Branches from Actin Filaments
Chan, C., Beltzner, C. C., & Pollard, T. D. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.060 · Cited by 203 · see citing works
Evolutionary expansion and anatomical specialization of synapse proteome complexity
Emes, R. D., Pocklington, A., Anderson, C. N. G., Bayés, À., Collins, M., Vickers, C., Croning, M., Malik, B., Choudhary, J., Armstrong, J., et al. (2008) · Nature Neuroscience · doi:10.1038/nn.2135 · Cited by 202 · see citing works
Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice
Soderling, S. H., Langeberg, L. K., Soderling, J. A., Davee, S. M., Simerly, R., Raber, J., & Scott, J. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438033100 · Cited by 202 · see citing works
Tolias, K. F., Bikoff, J. B., Kane, C. G., Tolias, C. S., Hu, L. S., & Greenberg, M. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702044104 · Cited by 201 · see citing works
Boettner, B., Govek, E., Cross, J. R., & Aelst, L. V. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9064 · Cited by 192 · see citing works
Dendritic pathology in mental retardation: from molecular genetics to neurobiology
Dierssen, M., & Ramakers, G. J. A. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00224.x · Cited by 190 · see citing works
De Novo SYNGAP1 Mutations in Nonsyndromic Intellectual Disability and Autism
Hamdan, F. F., Daoud, H., Piton, A., Gauthier, J., Dobrzeniecka, S., Krebs, M.-O., Joober, R., Lacaille, J.-C., Nadeau, A., Milunsky, J. M., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.11.015 · Cited by 187 · see citing works
Noguchi, J., Nagaoka, A., Watanabe, S., Ellis‐Davies, G. C. R., Kitamura, K., Kano, M., Matsuzaki, M., & Kasai, H. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.207100 · Cited by 173 · see citing works
Actin Out: Regulation of the Synaptic Cytoskeleton
Spence, E. F., & Soderling, S. H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.655118 · Cited by 171 · see citing works
Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes
Cahill, M. E., Xie, Z., Day, M., Photowala, H., Barbolina, M. V., Miller, C. A., Weiss, C., Radulovic, J., Sweatt, J. D., Disterhoft, J. F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904636106 · Cited by 170 · see citing works
Shi, Y., Pontrello, C. G., DeFea, K., Reichardt, L. F., & Ethell, I. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4681-08.2009 · Cited by 166 · see citing works
Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines
Woolfrey, K. M., Srivastava, D. P., Photowala, H., Yamashita, M., Barbolina, M. V., Cahill, M. E., Xie, Z., Jones, K. A., Quilliam, L. A., Prakriya, M., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2386 · Cited by 161 · see citing works
Self-citationPostsynaptic signaling during plasticity of dendritic spines
Murakoshi, H., & Yasuda, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.12.002 · Cited by 158 · see citing works
Rapid enhancement of two-step wiring plasticity by estrogen and NMDA receptor activity
Srivastava, D. P., Woolfrey, K. M., Jones, K. A., Shum, C. Y., Lash, L. L., Swanson, G. T., & Penzes, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801581105 · Cited by 155 · see citing works
Self-citationKasri, N. N., Nakano-Kobayashi, A., Malinow, R., Li, B., & Aelst, L. V. (2009) · Genes & Development · doi:10.1101/gad.1783809 · Cited by 146 · see citing works
Insights into Rapid Modulation of Neuroplasticity by Brain Estrogens
Srivastava, D. P., Woolfrey, K. M., & Penzes, P. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005272 · Cited by 138 · see citing works
Self-citationRapid Estrogen Signaling in the Brain: Implications for the Fine-Tuning of Neuronal Circuitry
Srivastava, D. P., Waters, E. M., Mermelstein, P. G., Kramár, E. A., Shors, T. J., & Liu, F. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4097-11.2011 · Cited by 137 · see citing works
Self-citationRegulation of hippocampal long-term potentiation by p21-activated protein kinase 1 (PAK1)
Asrar, S., Meng, Y., Zhou, Z., Todorovski, Z., Huang, W., & Jia, Z. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.055 · Cited by 129 · see citing works
Dendrites, dementia and the down syndrome
Takashima, S., Ieshima, A., Nakamura, H., & Becker, L. E. (1989) · Brain and Development · doi:10.1016/s0387-7604(89)80082-8 · Cited by 128 · see citing works
SynGAP Regulates Steady-State and Activity-Dependent Phosphorylation of Cofilin
Carlisle, H. J., Manzerra, P., Marcora, E., & Kennedy, M. B. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4695-08.2008 · Cited by 128 · see citing works
Adrenergic targets for the treatment of cognitive deficits in schizophrenia
Arnsten, A. F. T. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1724-3 · Cited by 127 · see citing works
Heumann, R., Goemans, C. G., Bartsch, D., Lingenhöhl, K., Waldmeier, P. C., Hengerer, B., ALLEGRINI, P. R., Schellander, K., Wagner, E. F., Arendt, T., et al. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.7.1537 · Cited by 127 · see citing works
Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders
Penzes, P., Buonanno, A., Passafaro, M., Sala, C., & Sweet, R. A. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12261 · Cited by 125 · see citing works
Plasticity of dendritic spines: subcompartmentalization of signaling
Colgan, L. A., & Yasuda, R. (2014) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170400 · Cited by 124 · see citing works
Huang, W., Zhou, Z., Asrar, S., Henkelman, R. M., Xie, W., & Jia, Z. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00969-10 · Cited by 124 · see citing works
The Neuropathology of Autism: A Review
Pickett, J., & London, E. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000186921.42592.6c · Cited by 122 · see citing works
Ye, X., & Carew, T. J. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.013 · Cited by 121 · see citing works
Biphasic synaptic Ca influx arising from compartmentalized electrical signals in dendritic spines
Bloodgood, B. L., Giessel, A. J., & Sabatini, B. L. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000190 · Cited by 119 · see citing works
Convergent CaMK and RacGEF signals control dendritic structure and function
Penzes, P., Cahill, M. E., Jones, K. A., & Srivastava, D. P. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.07.002 · Cited by 118 · see citing works
Self-citationBacchelli, E., Blasi, F., Biondolillo, M., Lamb, J. A., Bonora, E., Barnby, G., Parr, J., Beyer, K. S., Klauck, S. M., Poustka, A., et al. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001340 · Cited by 117 · see citing works
Xie, Z., Huganir, R. L., & Penzes, P. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.027 · Cited by 108 · see citing works
Structural plasticity: mechanisms and contribution to developmental psychiatric disorders
Bernardinelli, Y., Nikonenko, I., & Müller, D. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00123 · Cited by 108 · see citing works
Activity-Dependent Plasticity of the NMDA-Receptor Fractional Ca2+ Current
Sobczyk, A., & Svoboda, K. (2007) · Neuron · doi:10.1016/j.neuron.2006.11.016 · Cited by 106 · see citing works
Rho-linked genes and neurological disorders
Kasri, N. N., & Aelst, L. V. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0385-1 · Cited by 103 · see citing works
Estrogen Receptor β Activity Modulates Synaptic Signaling and Structure
Srivastava, D. P., Woolfrey, K. M., Liu, F., Brandon, N. J., & Penzes, P. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3264-10.2010 · Cited by 102 · see citing works
Self-citationLee, K. J., Lee, Y., Rozeboom, A. M., Lee, J.-Y., Udagawa, N., Hoe, H., & Pak, D. T. S. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.004 · Cited by 99 · see citing works
Long-TermIn VivoImaging of Dendritic Spines in the Hippocampus Reveals Structural Plasticity
Gu, L., Poll, S., Schmid, L., Nebeling, F. C., Chamoun, M., Steffen, J., Wagner, J., & Fuhrmann, M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1464-14.2014 · Cited by 99 · see citing works
PICK1 inhibition of the Arp2/3 complex controls dendritic spine size and synaptic plasticity
Nakamura, Y., Wood, C. L., Patton, A. P., Jaafari, N., Henley, J. M., Mellor, J. R., & Hanley, J. G. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.357 · Cited by 97 · see citing works
A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function
Zhou, Z., Meng, Y., Asrar, S., Todorovski, Z., & Jia, Z. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.031 · Cited by 96 · see citing works
Coordination of Synaptic Adhesion with Dendritic Spine Remodeling by AF-6 and Kalirin-7
Xie, Z., Photowala, H., Cahill, M. E., Srivastava, D. P., Woolfrey, K. M., Shum, C. Y., Huganir, R. L., & Penzes, P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1170-08.2008 · Cited by 96 · see citing works
Self-citationSolís, Ó., Limón, I. D., Flores‐Hernández, J., & Flores, G. (2007) · Synapse · doi:10.1002/syn.20381 · Cited by 94 · see citing works
Tropea, D., Majewska, A. K., Garcia, R., & Sur, M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1661-10.2010 · Cited by 92 · see citing works
Kerr, J. M., & Blanpied, T. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2927-11.2012 · Cited by 91 · see citing works
Nishimura, A., & Linder, M. E. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01398-12 · Cited by 86 · see citing works
Sanchez, A. M., Flamini, M. I., Fu, X.-D., Mannella, P., Giretti, M. S., Goglia, L., Genazzani, A. R., & Simoncini, T. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0408 · Cited by 86 · see citing works
Ryu, J., Futai, K., Feliú-Mójer, M. I., Weinberg, R. J., & Sheng, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1944-08.2008 · Cited by 85 · see citing works
Srivastava, D. P., Woolfrey, K. M., Jones, K. A., Anderson, C. T., Smith, K. R., Russell, T. A., Lee, H., Yasvoina, M. V., Wokosin, D. L., Özdi̇nler, P. H., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001350 · Cited by 85 · see citing works
Self-citationRapid modulation of synaptogenesis and spinogenesis by 17β-estradiol in primary cortical neurons
Sellers, K. J., Erli, F., Raval, P., Watson, I. A., Ding, C., & Srivastava, D. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00137 · Cited by 83 · see citing works
Self-citationKang, M.-G., Guo, Y., & Huganir, R. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812861106 · Cited by 82 · see citing works
Fu, Z., Lee, S. H., Simonetta, A., Hansen, J. D., Sheng, M., & Pak, D. T. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04195.x · Cited by 82 · see citing works
Wang, H.-D., & Deutch, A. Y. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301521 · Cited by 80 · see citing works
A Hypothesized Role for Dendritic Remodeling in the Etiology of Mood and Anxiety Disorders
Gorman, J. M., & Docherty, J. P. (2010) · Journal of Neuropsychiatry · doi:10.1176/jnp.2010.22.3.256 · Cited by 79 · see citing works
Saneyoshi, T., & Hayashi, Y. (2012) · Cytoskeleton · doi:10.1002/cm.21037 · Cited by 78 · see citing works
Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses
Duman, J. G., Mulherkar, S. A., Tu, Y.-K., Cheng, J. X., & Tolias, K. F. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.05.034 · Cited by 75 · see citing works
Cerri, C., Fabbri, A., Vannini, E., Spolidoro, M., Costa, M., Maffei, L., Fiorentini, C., & Caleo, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2617-11.2011 · Cited by 73 · see citing works
Social, Communication, and Cortical Structural Impairments in Epac2-Deficient Mice
Srivastava, D. P., Jones, K. A., Woolfrey, K. M., Burgdorf, J. S., Russell, T. A., Kalmbach, A., Lee, H., Yang, C., Bradberry, M. M., Wokosin, D. L., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1349-12.2012 · Cited by 72 · see citing works
Self-citationKonur, S., & Yuste, R. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.07.005 · Cited by 68 · see citing works
Regulation of the Mouse Medial Prefrontal Cortical Synapses by Endogenous Estradiol
Galvin, C., & Ninan, I. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.56 · Cited by 68 · see citing works
Neuronal structural remodeling: is it all about access?
Chen, J. L., & Nedivi, E. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.06.002 · Cited by 68 · see citing works
Neuronal activation of Ras regulates synaptic connectivity
Arendt, T., Gärtner, U., Seeger, G., Barmashenko, G., Palm, K., Mittmann, T., Li, Y., Huemmeke, M., Behrbohm, J., Brückner, M. K., et al. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03409.x · Cited by 65 · see citing works
George, J., Soares, C., Montersino, A., Béïque, J.-C., & Thomas, G. M. (2015) · eLife · doi:10.7554/elife.06327 · Cited by 58 · see citing works
Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines
Penzes, P., & Cahill, M. E. (2012) · Cytoskeleton · doi:10.1002/cm.21015 · Cited by 57 · see citing works
The Neurobiology of X-Linked Intellectual Disability
Bassani, S., Zapata, J., Gerosa, L., Moretto, E., Murru, L., & Passafaro, M. (2013) · The Neuroscientist · doi:10.1177/1073858413493972 · Cited by 54 · see citing works
Nethrapalli, I. S., Singh, M., Guan, X., Guo, Q., Lubahn, D. B., Korach, K. S., & Toran‐Allerand, C. D. (2001) · Endocrinology · doi:10.1210/endo.142.12.8546 · Cited by 52 · see citing works
Epac2-mediated dendritic spine remodeling: Implications for disease
Penzes, P., Woolfrey, K. M., & Srivastava, D. P. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.11.008 · Cited by 47 · see citing works
Self-citationBabayan, A. H., & Kramár, E. A. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12108 · Cited by 45 · see citing works
Ma, X., Huang, J., Kim, E., Zhu, Q. X., Kuchel, G. A., Mains, R. E., & Eipper, B. A. (2010) · Hippocampus · doi:10.1002/hipo.20780 · Cited by 42 · see citing works
Rap2 function requires palmitoylation and recycling endosome localization
Uechi, Y., Bayarjargal, M., Umikawa, M., Oshiro, M., Takei, K., Yamashiro, Y., Asato, T., Endo, S., Misaki, R., Taguchi, T., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.11.107 · Cited by 42 · see citing works
Afadin Is Required for Maintenance of Dendritic Structure and Excitatory Tone
Srivastava, D. P., Copits, B. A., Xie, Z., Huda, R., Jones, K. A., Mukherji, S., Cahill, M. E., VanLeeuwen, J., Woolfrey, K. M., Rafalovich, I., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.363358 · Cited by 30 · see citing works
Self-citationWurtzel, J. G. T., Kumar, P., & Goldfinger, L. E. (2012) · Small GTPases · doi:10.4161/sgtp.21084 · Cited by 27 · see citing works
VanLeeuwen, J., Rafalovich, I., Sellers, K. J., Jones, K. A., Griffith, T. N., Huda, R., Miller, R. J., Srivastava, D. P., & Penzes, P. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.536391 · Cited by 25 · see citing works
Self-citationA Hypothesized Role for Dendritic Remodeling in the Etiology of Mood and Anxiety Disorders
Gorman, J. M., & Docherty, J. P. (2010) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.22.3.256 · Cited by 22 · see citing works
Transgenic activation of Ras in neurons increases synapse formation in mouse neocortex
Seeger, G., Gärtner, U., & Arendt, T. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0226-8 · Cited by 16 · see citing works
PICK1 links AMPA receptor stimulation to Cdc42
Rocca, D. L., & Hanley, J. G. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.11.046 · Cited by 12 · see citing works
(2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810024105 · Cited by 8 · see citing works
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Millan, M. J. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.03.004 · Cited by 146 · see citing works
The Role of Actin Cytoskeleton in Dendritic Spines in the Maintenance of Long-Term Memory
Basu, S., & Lamprecht, R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00143 · Cited by 108 · see citing works
Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity
Matt, L., Kim, K., Chowdhury, D., & Hell, J. W. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00008 · Cited by 96 · see citing works
Wu, M., Minkowicz, S., Dumrongprechachan, V., Hamilton, P., & Kozorovitskiy, Y. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.022 · Cited by 93 · see citing works
Speranza, L., Labus, J., Volpicelli, F., Guseva, D., Lacivita, E., Leopoldo, M., Bellenchi, G. C., di Porzio, U., Bijata, M., Perrone‐Capano, C., et al. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.13962 · Cited by 91 · see citing works
Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities
Zamboni, V., Jones, R., Umbach, A., Ammoni, A., Passafaro, M., Hirsch, E., & Merlo, G. R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061821 · Cited by 83 · see citing works
Zaręba-Kozioł, M., Figiel, I., Bartkowiak, A., & Włodarczyk, J. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00175 · Cited by 59 · see citing works
Warnet, X. L., Bakke Krog, H., Sevillano‐Quispe, O. G., Poulsen, H., & Kjaergaard, M. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14842 · Cited by 50 · see citing works
Centella asiatica attenuates Aβ-induced neurodegenerative spine loss and dendritic simplification
Gray, N. E., Zweig, J. A., Murchison, C., Caruso, M., Matthews, D. G., Kawamoto, C., Harris, C. J., Quinn, J. F., & Soumyanath, A. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.02.072 · Cited by 49 · see citing works
Jedlička, P., & Deller, T. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.07.023 · Cited by 46 · see citing works
Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies
Sarowar, T., & Grabrucker, A. M. (2016) · Neural Plasticity · doi:10.1155/2016/8051861 · Cited by 46 · see citing works
Actin Cytoskeleton Role in the Maintenance of Neuronal Morphology and Long-Term Memory
Lamprecht, R. (2021) · Cells · doi:10.3390/cells10071795 · Cited by 45 · see citing works
Regulation of postsynaptic signaling in structural synaptic plasticity
Fu, A. K., & Ip, N. Y. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.05.016 · Cited by 43 · see citing works
Huang, M., Liang, C., Li, S., Zhang, J., Guo, D., Zhao, B., Liu, Y., Peng, Y., Xu, J., Liu, W., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00577 · Cited by 41 · see citing works
SUMOylation of synaptic and synapse‐associated proteins: An update
Henley, J. M., Seager, R., Nakamura, Y., Talandyte, K., Nair, J. D., & Wilkinson, K. A. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15103 · Cited by 40 · see citing works
Olabarria, M., Pasini, S., Corona, C., Robador, P. A., Song, C., Patel, H., & Lefort, R. (2019) · Communications Biology · doi:10.1038/s42003-019-0350-5 · Cited by 39 · see citing works
Reichova, A., Zatkova, M., Bačová, Z., & Bakoš, J. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24200 · Cited by 35 · see citing works
Glennon, E. B. C., Lau, D. H. W., Gabriele, R. M. C., Taylor, M. F., Troakes, C., Opie-Martin, S., Elliott, C., Killick, R., Hanger, D. P., Perez‐Nievas, B. G., et al. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa011 · Cited by 33 · see citing works
Rac1 is a downstream effector of PKCα in structural synaptic plasticity
Tu, X., Yasuda, R., & Colgan, L. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-58610-6 · Cited by 31 · see citing works
Fxr1 regulates sleep and synaptic homeostasis
Khlghatyan, J., Evstratova, A., Bozoyan, L., Chamberland, S., Chatterjee, D., Marakhovskaia, A., Silva, T. S., Tóth, K., Mongrain, V., & Beaulieu, J. (2020) · The EMBO Journal · doi:10.15252/embj.2019103864 · Cited by 33 · see citing works
Zhang, Y., Liu, M., Liu, Z., Zhao, J., Zhao, Y., Li, H., Li, W., & Zhang, J. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13108 · Cited by 31 · see citing works
DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants
Kwan, V., Meka, D. P., White, S. H., Hung, C. L.-K., Holzapfel, N. T., Walker, S., Murtaza, N., Unda, B. K., Schwanke, B., Yuen, R. K. C., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.047 · Cited by 30 · see citing works
Tsutiya, A., Nakano, Y., Hansen‐Kiss, E., Kelly, B., Nishihara, M., Goshima, Y., Corsmeier, D., White, P., Herman, G. E., & Ohtani‐Kaneko, R. (2017) · Scientific Reports · doi:10.1038/s41598-017-16782-8 · Cited by 25 · see citing works
Su, Y., Liu, J., Yu, B., Ba, R., & Zhao, C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00249 · Cited by 24 · see citing works
Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders
Erli, F., Palmos, A., Raval, P., Mukherjee, J. T., Sellers, K. J., Gatford, N. J. F., Moss, S. J., Brandon, N. J., Penzes, P., & Srivastava, D. P. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0682-4 · Cited by 22 · see citing works
Self-citationMMP-9 Signaling Pathways That Engage Rho GTPases in Brain Plasticity
Figiel, I., Kruk, P. K., Zaręba-Kozioł, M., Rybak, P., Bijata, M., Włodarczyk, J., & Dzwonek, J. (2021) · Cells · doi:10.3390/cells10010166 · Cited by 22 · see citing works
Rasia‐Filho, A. A., Guerra, K. T. K., Vásquez, C. E., Dall’Oglio, A., Reberger, R., Jung, C. R., & Calcagnotto, M. E. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.616607 · Cited by 24 · see citing works
Shehjar, F., Almarghalani, D. A., Mahajan, R., Hasan, S. A.-M., & Shah, Z. A. (2024) · Cells · doi:10.3390/cells13020188 · Cited by 22 · see citing works
Latzer, P., Shchyglo, O., Hartl, T., Matschke, V., Schlegel, U. S., Manahan‐Vaughan, D., & Theiß, C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00113 · Cited by 22 · see citing works
Szatmari, E. M., Moran, C., Cohen, S. J., Jacob, A., Parra-Bueno, P., Kamasawa, N., Guerrero‐Given, D., Klein, M., Stackman, R. W., & Yasuda, R. (2020) · eNeuro · doi:10.1523/eneuro.0111-20.2020 · Cited by 18 · see citing works
Sui, S., Tian, J., Gauba, E., Wang, Q., Guo, L., & Du, H. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14484 · Cited by 19 · see citing works
Dendritic and Spine Heterogeneity of von Economo Neurons in the Human Cingulate Cortex
Correa-Júnior, N. D., Renner, J., Fuentealba-Villarroel, F., Hilbig, A., & Rasia‐Filho, A. A. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00025 · Cited by 18 · see citing works
Kermath, B. A., Vanderplow, A. M., Bjornson, K. J., Seablom, E. N., Novak, A., Bernhardt, C. R., & Cahill, M. E. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0835-0 · Cited by 17 · see citing works
Lim, C. S., & Alkon, D. L. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.775619 · Cited by 18 · see citing works
Li, Z., Lan, Y., Zhao, K., Lv, X., Ding, N., Lu, H., Zhang, J., Huiqing, Y., Shi, J., Song, D., et al. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00155 · Cited by 18 · see citing works
Rho-Kinase/ROCK Phosphorylates PSD-93 Downstream of NMDARs to Orchestrate Synaptic Plasticity
Hossen, E., Funahashi, Y., Faruk, M. O., Ahammad, R. U., Amano, M., Yamada, K., & Kaibuchi, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010404 · Cited by 18 · see citing works
Sun, T., Liu, Z., Liu, M., Guo, Y., Sun, H., Zhao, J., Lan, Z., Lian, B., & Zhang, J. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.014 · Cited by 17 · see citing works
Mahalakshmi, A. M., Ray, B., Tuladhar, S., Hediyal, T. A., Raj, P., Rathipriya, A. G., Qoronfleh, M. W., Essa, M. M., & Chidambaram, S. B. (2021) · Cells · doi:10.3390/cells10123405 · Cited by 16 · see citing works
Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling
Wang, X., Weng, M., Ke, Y., Sapp, E., DiFiglia, M., & Li, X. (2020) · Cells · doi:10.3390/cells9051132 · Cited by 15 · see citing works
Palmitoylated Proteins in Dendritic Spine Remodeling
Albanesi, J. P., Baryłko, B., Demartino, G., & Jameson, D. M. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00022 · Cited by 13 · see citing works
Wang, X., Xu, M., Xu, Q., Yang, F., Tang, H., Shao, C., Wang, L., Wang, Y., Deng, J., & Wang, S. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/4947 · Cited by 12 · see citing works
van Bommel, B., & Mikhaylova, M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.016 · Cited by 11 · see citing works
Qiu, W., Wang, X., Zhang, S., Zhang, Z., Zhang, K., Shao, Z., Liu, Y., Wei, R., Chu, L., & Luo, P. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04003-5 · Cited by 9 · see citing works
Yang, X. Y., Stanley, R., Ross, A. P., Robitaille, A. M., Gray, J. A., & Cheyette, B. N. R. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx333 · Cited by 9 · see citing works
Alexander, C. J., Barzik, M., Fujiwara, I., Remmert, K., Wang, Y., Petralia, R. S., Friedman, T. B., & Hammer, J. A. (2020) · The FASEB Journal · doi:10.1096/fj.202001449r · Cited by 9 · see citing works
NCK1 Modulates Neuronal Actin Dynamics and Promotes Dendritic Spine, Synapse, and Memory Formation
Diab, A. M., Wigerius, M., Quinn, D. P., Qi, J., Shahin, I., Paffile, J., Krueger, K., Karten, B., Krueger, S., & Fawcett, J. P. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0495-21.2022 · Cited by 8 · see citing works
De Novo Transcriptome Profiling of Brain Tissue from the Annual Killifish Nothobranchius guentheri
Guvatova, Z. G., Fedorova, M., Vershinina, Y. S., Pudova, E. A., Lipatova, A. V., Volodin, V. V., Gladysh, N. S., Tokarev, A. T., Kornev, A. B., Pavlov, V., et al. (2021) · Life · doi:10.3390/life11020137 · Cited by 7 · see citing works
Koffman, E. E., Kruse, C. M., Singh, K., Naghavi, F. S., Curtis, M. A., Egbo, J., Houdi, M., Lin, B., Lü, H., Dębiec, J., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.155341 · Cited by 7 · see citing works
Ramírez‐Franco, J., Debreux, K., Sangiardi, M., Belghazi, M., Kim, Y., Lee, S., Lévêque, C., SEAGAR, M. J., & Far, O. E. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106513 · Cited by 6 · see citing works
Doody, N. E., Smith, N. J., Akam, E. C., Askew, G. N., Kwok, J. C. F., & Ichiyama, R. M. (2024) · Journal of Neurophysiology · doi:10.1152/jn.00422.2023 · Cited by 5 · see citing works
Tan, W., Ma, J., Fu, J., Wu, B., Zhu, Z., Huang, X., Du, M., Wu, C., Balawi, E., Zhou, Q., et al. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.374135 · Cited by 5 · see citing works
Sellers, K. J., Watson, I. A., Gresz, R. E., Raval, P., & Srivastava, D. P. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.041 · Cited by 5 · see citing works
Self-citationKCC2 regulates dendritic spine development
Llano, O., Rivera, C., & Ludwig, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815318-5.00006-6 · Cited by 5 · see citing works
Preveza, N. J., Setenet, G., Gwin, P., Bae, Y., Patrick, M. B., Cummings, A., Abraham, J. R., Ray, W. K., Helm, R. F., & Jarome, T. J. (2024) · Hippocampus · doi:10.1002/hipo.23650 · Cited by 4 · see citing works
Mice lacking acid-sensing ion channel 2 in the medial prefrontal cortex exhibit social dominance
Lin, B., Jin, Z. H., Park, K. A., Ge, Q., Singh, K., Ryan, W. G., Imami, A. S., Naghavi, F., Miller, O. A., Khan, S., et al. (2024) · Science Advances · doi:10.1126/sciadv.adn7573 · Cited by 3 · see citing works
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Wu, M., Minkowicz, S., Dumrongprechachan, V., Hamilton, P. J., Xiao, L., & Kozorovitskiy, Y. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.11.987818 · Cited by 3 · see citing works
Ramírez‐Franco, J., Debreux, K., Sangiardi, M., Belghazi, M., Kim, Y., Lee, S., Lévêque, C., SEAGAR, M. J., & Far, O. E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.24.550266 · Cited by 3 · see citing works
Krüssel, S., Deb, I., Son, S., Ewall, G., Chang, M., Lee, H., Heo, W. D., & Kwon, H. (2024) · iScience · doi:10.1016/j.isci.2024.110535 · Cited by 1 · see citing works
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Matsuki, T., Tabata, H., Ueda, M., Ito, H., Nagata, K., Tsuneura, Y., Eda, S., Kasai, K., & Nakayama, A. (2025) · Cells · doi:10.3390/cells14020062 · Cited by 2 · see citing works
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Albanesi, J. P., Liou, J., Jui-Yu-Yeh, & Yin, H. L. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2026.159726 · Cited by 1 · see citing works
Ras-related C3 botulinum toxin substrate 1 role in pathophysiology of neurological diseases
Le, N. M., & Li, J. (2022) · Brain Hemorrhages · doi:10.1016/j.hest.2022.05.005 · Cited by 1 · see citing works
Yang, Y., Kang, J., Zhang, Y., Cai, Y., Fang, Q., Huang, Y., Huang, C., Chen, Q., He, Y., & Lin, F. (2025) · Brain and Development · doi:10.1016/j.braindev.2025.104357 · Cited by 1 · see citing works
Zhang, X., Li, J., & Wu, A.-S. (2020) · doi:10.21203/rs.3.rs-30634/v1 · Cited by 1 · see citing works
Rapid Modulation of Spinogenesis by Estradiol in the Neocortex
Srivastava, D. P., Sellers, K. J., & Evans, P. D. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190645908.003.0005
Self-citationProton receptors regulate synapse-specific reconsolidation in the amygdalaPreprint
Koffman, E. E., Kruse, C. M., Singh, K., Naghavi, F., Egbo, J., Boateng, S., Houdi, M., Lin, B., Dębiec, J., & Du, J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.04.425235
Gupton, S. L., & Menon, S. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727376788.793552048
Zhang, X., & Li, J. (2023) · Journal of International Medical Research · doi:10.1177/03000605231169214
SARS-CoV-2 neurotropism-induced anxiety/depression-like behaviors require Microglia activationPreprint
Ge, Q., Zhou, S., Porras, J., Fu, P., Wang, T., Du, J., & Li, K. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.02.560570
Pathogenic human autoantibodies against NMDA receptor alter dendritic spine size
Matsuda, S., Mori, T., Kasai, M., Kohyama, K., Shimada, T., & Sakuma, H. (2026) · Scientific Reports · doi:10.1038/s41598-025-34027-x
Devadoss, D., Akkaoui, J., Vashist, A., Yndart, A., Nefzi, A., & Lakshmana, M. K. (2026) · Neurology International · doi:10.3390/neurolint18050096
Wang, T., Tzeng, I., Chen, Y.-C., & Chen, M. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48070694
Jia, Y., Li, S., Tang, S., Gu, K., & Chen, S. (2026) · Advanced Science · doi:10.1002/advs.77524
- Authors
- Woolfrey, K. M., & Srivastava, D. P.
- Affiliations
- University of Colorado Anschutz (US)
- King's College London (GB)
- Corresponding author
- Woolfrey, Kevin M.
- Srivastava, Deepak P.
- Venue
- Neural Plasticity
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-12
- ISSN
- 1687-5443 (ISSN-L)
- 2090-5904
- PMC
- PMC4775798
- OpenAlex
- W2287224568
- Cited by
- 76
- References
- 150
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 18 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 4
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Neural Plasticity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Medical Research Council
- Royal Society
- Brain and Behaviour Foundation
- Psychiatric Research Trust
- American Heart Association
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- dendritic spines, small GTPases, structural synaptic plasticity, excitatory synapses, actin dynamics, dendritic spine morphology, synaptic signalling, cognitive impairment, neurodevelopmental disorders, neurodegenerative diseases
- MeSH terms
- Animals, Brain, Humans, Microfilament Proteins, Neuronal Plasticity, Neurons, Signal Transduction, Monomeric GTP-Binding Proteins, Dendritic Spines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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