Cited by 76Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersProtein Kinase Regulation and GTPase Signaling

Control of dendritic spine morphological and functional plasticity by small GTPases.

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Woolfrey, Kevin M., Srivastava, Deepak P.·2016·Neural Plasticity

Abstract

Structural plasticity of excitatory synapses is a vital component of neuronal development, synaptic plasticity, and behaviour. Abnormal development or regulation of excitatory synapses has also been strongly implicated in many neurodevelopmental, psychiatric, and neurodegenerative disorders. In the mammalian forebrain, the majority of excitatory synapses are located on dendritic spines, specialized dendritic protrusions that are enriched in actin. Research over recent years has begun to unravel the complexities involved in the regulation of dendritic spine structure. The small GTPase family of proteins have emerged as key regulators of structural plasticity, linking extracellular signals with the modulation of dendritic spines, which potentially underlies their ability to influence cognition. Here we review a number of studies that examine how small GTPases are activated and regulated in neurons and furthermore how they can impact actin dynamics, and thus dendritic spine morphology. Elucidating this signalling process is critical for furthering our understanding of the basic mechanisms by which information is encoded in neural circuits but may also provide insight into novel targets for the development of effective therapies to treat cognitive dysfunction seen in a range of neurological disorders.

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Authors
Woolfrey, K. M., & Srivastava, D. P.
Affiliations
  • University of Colorado Anschutz (US)
  • King's College London (GB)
Corresponding author
  • Woolfrey, Kevin M.
  • Srivastava, Deepak P.
Venue
Neural Plasticity
Publisher
Wiley
Published
2016
Volume
2016
Pages
1-12
ISSN
  • 1687-5443 (ISSN-L)
  • 2090-5904
OpenAlex
W2287224568
Cited by
76
References
150
Citations by year
2026: 5 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 18 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 4
FWCI
0.95
Type
journal article
Language
en
Open access
Locations
  • Neural Plasticity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Medical Research Council
  • Royal Society
  • Brain and Behaviour Foundation
  • Psychiatric Research Trust
  • American Heart Association
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
dendritic spines, small GTPases, structural synaptic plasticity, excitatory synapses, actin dynamics, dendritic spine morphology, synaptic signalling, cognitive impairment, neurodevelopmental disorders, neurodegenerative diseases
MeSH terms
Animals, Brain, Humans, Microfilament Proteins, Neuronal Plasticity, Neurons, Signal Transduction, Monomeric GTP-Binding Proteins, Dendritic Spines

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