Dendritic Spine Initiation in Brain Development, Learning and Diseases and Impact of BAR-Domain Proteins
Open accessAbstract
Dendritic spines are small, bulbous protrusions along neuronal dendrites where most of the excitatory synapses are located. Dendritic spine density in normal human brain increases rapidly before and after birth achieving the highest density around 2–8 years. Density decreases during adolescence, reaching a stable level in adulthood. The changes in dendritic spines are considered structural correlates for synaptic plasticity as well as the basis of experience-dependent remodeling of neuronal circuits. Alterations in spine density correspond to aberrant brain function observed in various neurodevelopmental and neuropsychiatric disorders. Dendritic spine initiation affects spine density. In this review, we discuss the importance of spine initiation in brain development, learning, and potential complications resulting from altered spine initiation in neurological diseases. Current literature shows that two Bin Amphiphysin Rvs (BAR) domain-containing proteins, MIM/Mtss1 and SrGAP3, are involved in spine initiation. We review existing literature and open databases to discuss whether other BAR-domain proteins could also take part in spine initiation. Finally, we discuss the potential molecular mechanisms on how BAR-domain proteins could regulate spine initiation.
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- Authors
- Khanal, P., & Hotulainen, P.
- Affiliations
- University of Helsinki (FI)
- Minerva Foundation (FI)
- Corresponding author
- Hotulainen, Pirta
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2021-09-12
- Volume
- 10
- Issue
- 9
- Pages
- 2392
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC8468246
- OpenAlex
- W3201176067
- Cited by
- 60
- References
- 177
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 9 · 2023: 12 · 2022: 7 · 2021: 2
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Työväentutkimus Vuosikirja (submittedVersion)
- Funders
- Academy of Finland (SA 307735)
- doctoral programme brain & mind (PK)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- dendritic spine density, BAR domain proteins, synaptic plasticity, brain development, learning, neurodevelopmental disorders, neuropsychiatric disorders, excitatory synapses
- MeSH terms
- Protein Domains, Brain, Brain Diseases, Humans, Learning, Nuclear Proteins, Tumor Suppressor Proteins, Adaptor Proteins, Signal Transducing, Dendritic Spines
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