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Uterine Wnt/β-catenin signaling is required for implantation
Open accessAbstract
Successful implantation relies on precisely orchestrated and reciprocal signaling between the implanting blastocyst and the receptive uterus. We have examined the role of the Wnt/β-catenin signaling pathway during the process of implantation and demonstrate that this pathway is activated during two distinct stages. Wnt/β-catenin signaling is first transiently activated in circular smooth muscle forming a banding pattern of activity within the uterus on early day 4. Subsequently, activation is restricted to the luminal epithelium at the prospective site of implantation. Activation at both sites requires the presence of the blastocyst. Furthermore, inhibition of Wnt/β-catenin signaling interferes with the process of implantation. Our results demonstrate that the Wnt/β-catenin signaling pathway plays a central role in coordinating uterus–embryo interactions required for implantation.
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Cited by
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Macer, M. L., & Taylor, H. S. (2012) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2012.10.002 · Cited by 681
Physiological and molecular determinants of embryo implantation
Zhang, S., Lin, H., Kong, S., Wang, S., Wang, H., Wang, H., & Armant, D. R. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.12.011 · Cited by 587
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Kihara, Y., Maceyka, M., Spiegel, S., & Chun, J. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12678 · Cited by 324
Jeong, J.-W., Lee, H. S., Franco, H. L., Broaddus, R. R., Taketo, M. M., Tsai, S. Y., Lydon, J. P., & DeMayo, F. J. (2009) · Oncogene · doi:10.1038/onc.2008.363 · Cited by 196
Metadata
- Authors
- Mohamed, O. A., Jonnaert, M., Labelle-Dumais, C., Kuroda, K., Clarke, H. J., & Dufort, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-06
- Volume
- 102
- Issue
- 24
- Pages
- 8579-8584
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2080397589
- Cited by
- 221
- References
- 0
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Mohamed, O. A., Jonnaert, M., Labelle-Dumais, C., Kuroda, K., Clarke, H. J., & Dufort, D. (2005). Uterine Wnt/β-catenin signaling is required for implantation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0500612102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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