The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The neurotrophin receptor p75 NTR modulates long-term depression and regulates the expression of AMPA receptor subunits in the hippocampus
Open accessAbstract
Neurotrophins are involved in the modulation of synaptic transmission, including the induction of long-term potentiation (LTP) through the receptor TrkB. Because previous studies have revealed a bidirectional mode of neurotrophin action by virtue of signaling through either the neurotrophin receptor p75 NTR or the Trk receptors, we tested the hypothesis that p75 NTR is important for longterm depression (LTD) to occur. Although LTP was found to be unaffected in hippocampal slices of two different strains of mice carrying mutations of the p75 NTR gene, hippocampal LTD was impaired in both p75 NTR -deficient mouse strains. Furthermore, the expression levels of two ( RS )-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunits, GluR2 and GluR3, but not GluR1 or GluR4, were found to be significantly altered in the hippocampus of p75 NTR -deficient mice. These results implicate p75 NTR in activity-dependent synaptic plasticity and extend the concept of functional antagonism of the neurotrophin signaling system.
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Cites
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Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
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Postsynaptic signaling and plasticity mechanisms
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Neurotrophin-evoked depolarization requires the sodium channel NaV1.9
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Synaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3
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Cited by
The yin and yang of neurotrophin action
Lu, B., Pang, P. T., & Woo, N. H. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1726 · Cited by 1,356
New insights into BDNF function in depression and anxiety
Martinowich, K., Manji, H., & Lu, B. (2007) · Nature Neuroscience · doi:10.1038/nn1971 · Cited by 1,221
TrkB signalling pathways in LTP and learning
Minichiello, L. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2738 · Cited by 1,055
BDNF and synaptic plasticity, cognitive function, and dysfunction
Lu, B., Nagappan, G., & Lu, Y. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-45106-5_9 · Cited by 1,043
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1510 · Cited by 815
Metadata
- Authors
- Rösch, H., Schweigreiter, R., Bonhoeffer, T., Barde, Y.-A., & Korte, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-05-09
- Volume
- 102
- Issue
- 20
- Pages
- 7362-7367
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1978646572
- Cited by
- 184
- References
- 10
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Rösch, H., Schweigreiter, R., Bonhoeffer, T., Barde, Y.-A., & Korte, M. (2005). The neurotrophin receptor p75 NTR modulates long-term depression and regulates the expression of AMPA receptor subunits in the hippocampus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0502460102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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