Postsynaptic signaling and plasticity mechanisms

AMPA Receptor Trafficking and Synaptic Plasticity

Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588 · see citing works

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686 · see citing works

PSD-95 Involvement in Maturation of Excitatory Synapses

El-Husseini, A. E.-D., Schnell, E., Chetkovich, D. M., Nicoll, R. A., & Bredt, D. S. (2000) · Science · doi:10.1126/science.290.5495.1364 · Cited by 1,303 · see citing works

Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111 · see citing works

Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD

Beattie, E. C., Carroll, R. C., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., & Malenka, R. C. (2000) · Nature Neuroscience · doi:10.1038/81823 · Cited by 745 · see citing works

Interaction with the NMDA receptor locks CaMKII in an active conformation

Bayer, K.-U., De Koninck, P., Leonard, A. S., Hell, J. W., & Schulman, H. (2001) · Nature · doi:10.1038/35081080 · Cited by 732 · see citing works

Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons

Passafaro, M., Piëch, V., & Sheng, M. (2001) · Nature Neuroscience · doi:10.1038/nn0901-917 · Cited by 655 · see citing works

Regulation of AMPA receptor lateral movements

Borgdorff, A. J., & Choquet, D. (2002) · Nature · doi:10.1038/nature00780 · Cited by 542 · see citing works

Subunit-Specific NMDA Receptor Trafficking to Synapses

Barria, A., & Malinow, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00776-6 · Cited by 515 · see citing works

An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing

Scott, D. B., Blanpied, T. A., Swanson, G. T., Zhang, C., & Ehlers, M. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03063.2001 · Cited by 418 · see citing works

Visualization of changes in presynaptic function during long-term synaptic plasticity

Zakharenko, S. S., Zablow, L., & Siegelbaum, S. A. (2001) · Nature Neuroscience · doi:10.1038/89498 · Cited by 305 · see citing works

Regulation of Synaptic Strength by Protein Phosphatase 1

Morishita, W., Connor, J. H., Xia, H., Quinlan, E. M., Shenolikar, S., & Malenka, R. C. (2001) · Neuron · doi:10.1016/s0896-6273(01)00554-2 · Cited by 227 · see citing works

AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss

Hsieh, H., Boehm, J., Sato, C., Iwatsubo, T., Tomita, T., Sisodia, S., & Malinow, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.035 · Cited by 1,042 · see citing works

The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View

Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,003 · see citing works

Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system

Ehlers, M. D. (2003) · Nature Neuroscience · doi:10.1038/nn1013 · Cited by 977 · see citing works

Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories

Plath, N., Ohana, O., Dammermann, B., Errington, M. L., Schmitz, D., Gross, C., Mao, X., Engelsberg, A., Mahlke, C., Welzl, H., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.024 · Cited by 827 · see citing works

Postsynaptic receptor trafficking underlying a form of associative learning

Rumpel, S., LeDoux, J., Zador, A., & Malinow, R. (2005) · Science · doi:10.1126/science.1103944 · Cited by 775 · see citing works

The Postsynaptic Organization of Synapses

Sheng, M., & Kim, E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005678 · Cited by 603 · see citing works

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

Bozdagi, O., Sakurai, T., Papapetrou, D., Wang, X., Dickstein, D. L., Takahashi, N., Kajiwara, Y., Yang, M., Katz, A. M., Scattoni, M. L., et al. (2010) · Molecular Autism · doi:10.1186/2040-2392-1-15 · Cited by 584 · see citing works

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2

Beffert, U., Weeber, E. J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J. D., Li, W.-P., Adelmann, G., Frotscher, M., Hammer, R. E., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.007 · Cited by 497 · see citing works

Relative and Absolute Quantification of Postsynaptic Density Proteome Isolated from Rat Forebrain and Cerebellum

Cheng, D., Hoogenraad, C. C., Rush, J., Ramm, E., Schlager, M. A., Duong, D. M., Xu, P., Wijayawardana, S. R., Hanfelt, J., Nakagawa, T., et al. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.d500009-mcp200 · Cited by 510 · see citing works

AMPA Receptor Incorporation into Synapses during LTP: The Role of Lateral Movement and Exocytosis

Makino, H., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.035 · Cited by 501 · see citing works

Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking

Kim, M. J., Dunah, A. W., Wang, Y. T., & Sheng, M. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.031 · Cited by 494 · see citing works

Stargazin modulates AMPA receptor gating and trafficking by distinct domains

Tomita, S., Adesnik, H., Sekiguchi, M., Zhang, W., Wada, K., Howe, J. R., Nicoll, R. A., & Bredt, D. S. (2005) · Nature · doi:10.1038/nature03624 · Cited by 486 · see citing works

Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression

Bellone, C., & Lüscher, C. (2006) · Nature Neuroscience · doi:10.1038/nn1682 · Cited by 429 · see citing works

Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression

Feyissa, A. M., Chandran, A., Stockmeier, C. A., & Karolewicz, B. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.10.005 · Cited by 421 · see citing works

Complement<i>C3</i>-Deficient Mice Fail to Display Age-Related Hippocampal Decline

Shi, Q., Colodner, K. J., Matousek, S. B., Merry, K., Hong, S., Kenison, J. E., Frost, J. L., Le, K. X., Li, S., Dodart, J.-C., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1698-15.2015 · Cited by 368 · see citing works

Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1

Hung, A. Y., Futai, K., Sala, C., Valtschanoff, J. G., Ryu, J., Woodworth, M. A., Kidd, F. L., Sung, C. C., Miyakawa, T., Bear, M. F., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3032-07.2008 · Cited by 350 · see citing works

Postsynaptic Density-95 Mimics and Occludes Hippocampal Long-Term Potentiation and Enhances Long-Term Depression

Stein, V., House, D. R. C., Bredt, D. S., & Nicoll, R. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05503.2003 · Cited by 341 · see citing works

Presynaptic Regulation of Quantal Size by the Vesicular Glutamate Transporter VGLUT1

Wilson, N. R., Kang, J., Hueske, E. V., Leung, T., Varoqui, H., Murnick, J. G., Erickson, J. D., & Liu, G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3003-04.2005 · Cited by 335 · see citing works

An Architectural Framework That May Lie at the Core of the Postsynaptic Density

Baron, M. K., Boeckers, T. M., Vaida, B., Faham, S., Gingery, M., Sawaya, M. R., Salyer, D., Gundelfinger, E. D., & Bowie, J. U. (2006) · Science · doi:10.1126/science.1118995 · Cited by 292 · see citing works

Synaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3

Meng, Y., Zhang, Y., & Jia, Z. (2003) · Neuron · doi:10.1016/s0896-6273(03)00368-4 · Cited by 251 · see citing works

Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II

Djakovic, S. N., Schwarz, L. A., Barylko, B., DeMartino, G. N., & Patrick, G. N. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.021956 · Cited by 236 · see citing works

Ontogeny of postsynaptic density proteins at glutamatergic synapses

Petralia, R. S., Sans, N., Wang, Y.-X., & Wenthold, R. J. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.03.013 · Cited by 236 · see citing works

Analyzing dendritic spine pathology in Alzheimer’s disease: Problems and opportunities

Dorostkar, M. M., Zou, C., Blazquez-Llorca, L., & Herms, J. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1449-5 · Cited by 235 · see citing works

Photoinactivation of native AMPA receptors reveals their real-time trafficking

Adesnik, H., Nicoll, R. A., & England, P. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.11.030 · Cited by 234 · see citing works

Regulation of AMPA receptor surface diffusion by PSD-95 slots

Opazo, P., Sainlos, M., & Choquet, D. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.010 · Cited by 234 · see citing works

Metabotropic Glutamate Receptor-Mediated Long-Term Depression: Molecular Mechanisms

Gladding, C. M., Fitzjohn, S. M., & Molnár, E. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001735 · Cited by 233 · see citing works

Interneuron Diversity series: Containing the detonation – feedforward inhibition in the CA3 hippocampus

Lawrence, J. J., & McBain, C. J. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.007 · Cited by 214 · see citing works

Determination of absolute protein numbers in single synapses by a GFP-based calibration technique

Sugiyama, Y., Kawabata, I., Sobue, K., & Okabe, S. (2005) · Nature Methods · doi:10.1038/nmeth783 · Cited by 189 · see citing works

The Shank Family of Postsynaptic Density Proteins Interacts with and Promotes Synaptic Accumulation of the βPIX Guanine Nucleotide Exchange Factor for Rac1 and Cdc42

Park, E., Na, M., Choi, J., Kim, S., Lee, J.-R., Yoon, J., Park, D., Sheng, M., & Kim, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301052200 · Cited by 175 · see citing works

Selective activation of microglia facilitates synaptic strength

Clark, A. K., Gruber-Schoffnegger, D., Drdla-Schutting, R., Gerhold, K. J., Malcangio, M., & Sandkühler, J. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2061-14.2015 · Cited by 171 · see citing works

Long-term potentiation of exogenous glutamate responses at single dendritic spines

Bagal, A. A., Kao, J. P. Y., Tang, C.-M., & Thompson, S. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501956102 · Cited by 169 · see citing works

Common Molecular Pathways Mediate Long-Term Potentiation of Synaptic Excitation and Slow Synaptic Inhibition

Huang, C. S., Shi, S.-H., Ule, J., Ruggiu, M., Barker, L. A., Darnell, R. B., Jan, Y. N., & Jan, L. Y. (2005) · Cell · doi:10.1016/j.cell.2005.07.033 · Cited by 157 · see citing works

Analysis of knock-out mice to determine the role of HPC-1/syntaxin 1A in expressing synaptic plasticity

Fujiwara, T., Mishima, T., Kofuji, T., Chiba, T., Tanaka, K., Yamamoto, A., & Akagawa, K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0289-06.2006 · Cited by 125 · see citing works

Effect of varied gestational stress on acquisition of spatial memory, hippocampal LTP and synaptic proteins in juvenile male rats

Yaka, R., Salomon, S., Matzner, H., & Weinstock, M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.01.018 · Cited by 120 · see citing works

Endocytosis as a Mechanism for Tyrosine Kinase-dependent Suppression of a Voltage-gated Potassium Channel

Nesti, E., Everill, B., & Morielli, A. D. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-11-0788 · Cited by 94 · see citing works

SynGAP isoforms exert opposing effects on synaptic strength

McMahon, A. C., Barnett, M. W., O'Leary, T. S., Stoney, P. N., Collins, M. O., Papadia, S., Choudhary, J. S., Komiyama, N. H., Grant, S. G. N., Hardingham, G. E., et al. (2012) · Nature Communications · doi:10.1038/ncomms1900 · Cited by 91 · see citing works

Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2

Kastning, K., Kukhtina, V., Kittler, J. T., Chen, G., Pechstein, A., Enders, S., Lee, S. H., Sheng, M., Yan, Z., & Haucke, V. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611170104 · Cited by 88 · see citing works

Synaptically released matrix metalloproteinase activity in control of structural plasticity and the cell surface distribution of GluA1-AMPA receptors

Szepesi, Z., Hosy, E., Ruszczycki, B., Bijata, M., Pyskaty, M., Bikbaev, A., Heine, M., Choquet, D., Kaczmarek, L., & Wlodarczyk, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098274 · Cited by 83 · see citing works

Two Loci of Expression for Long-Term Depression at Hippocampal Mossy Fiber-Interneuron Synapses

Lei, S., & McBain, C. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4645-03.2004 · Cited by 85 · see citing works

Dynamics of nascent and active zone ultrastructure as synapses enlarge during long‐term potentiation in mature hippocampus

Bell, M. E., Bourne, J. N., Chirillo, M. A., Mendenhall, J. M., Kuwajima, M., & Harris, K. M. (2014) · Journal of Comparative Neurology · doi:10.1002/cne.23646 · Cited by 72 · see citing works

IgLON cell adhesion molecule Kilon is a crucial modulator for synapse number in hippocampal neurons

Hashimoto, T., Yamada, M., Maekawa, S., Nakashima, T., & Miyata, S. (2008) · Brain Research · doi:10.1016/j.brainres.2008.05.069 · Cited by 71 · see citing works

Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation

Etiévant, A., Oosterhof, C., Bétry, C., Abrial, E., Novo-Perez, M., Rovera, R., Scarna, H., Devader, C., Mazella, J., Wegener, G., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.06.023 · Cited by 65 · see citing works

A role for ERKII in synaptic pattern selectivity on the time‐scale of minutes

Ajay, S. M., & Bhalla, U. S. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03725.x · Cited by 64 · see citing works

Barriers in the brain: resolving dendritic spine morphology and compartmentalization

Adrian, M., Kusters, R., Wierenga, C. J., Storm, C., Hoogenraad, C. C., & Kapitein, L. C. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00142 · Cited by 62 · see citing works

Acute exposure to CXC chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices

Vlkolinský, R., Siggins, G. R., Campbell, I. L., & Krucker, T. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.01.011 · Cited by 57 · see citing works

Organization of postsynaptic density proteins and glutamate receptors in axodendritic and dendrodendritic synapses of the rat olfactory bulb

Sassoé‐Pognetto, M., Utvik, J. K., Camoletto, P., Watanabe, M., Stephenson, F. A., Bredt, D. S., & Ottersen, O. P. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10745 · Cited by 45 · see citing works

DAPK1: a Novel Pathology and Treatment Target for Alzheimer’s Disease

Xu, L.-Z., Li, B.-Q., & Jia, J.-P. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1242-2 · Cited by 42 · see citing works

Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease

Chen, G., Chen, P., Tan, H., Ma, D., Dou, F., Feng, J., & Yan, Z. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.023 · Cited by 36 · see citing works

Genetic Evidence for the Association between the Early Growth Response 3 (EGR3) Gene and Schizophrenia

Zhang, R., Lu, S., Meng, L., Min, Z., Tian, J., Valenzuela, R. K., Guo, T., Tian, L., Zhao, W., & Ma, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030237 · Cited by 30 · see citing works

Exposure of mother rats to chronic unpredictable stress before pregnancy alters the metabolism of gamma-aminobutyric acid and glutamate in the right hippocampus of offspring in early adolescence in a sexually dimorphic manner

Huang, Y., Shen, Z., Hu, L., Xia, F., Li, Y., Zhuang, J., Chen, P., & Huang, Q. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.10.005 · Cited by 22 · see citing works