The DOI matches its Crossref record.
ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa
Open accessAbstract
Type III secretion systems are toxin delivery systems that are present in a large number of pathogens. A hallmark of all type III secretion systems studied to date is that expression of one or more of their components is induced upon cell contact. It has been proposed that this induction is controlled by a negative regulator that is itself secreted by means of the type III secretion machinery. Although candidate proteins for this negative regulator have been proposed in a number of systems, for the most part, a direct demonstration of their role in regulation is lacking. Here, we report the discovery of ExsE, a negative regulator of type III secretion gene expression in Pseudomonas aeruginosa . Deletion of exsE deregulates expression of the type III secretion genes. We provide evidence that ExsE is itself secreted by means of the type III secretion machinery and physically interacts with ExsC, a positive regulator of the type III secretion regulon. Taken together, these data demonstrate that ExsE is the secreted negative regulator that couples triggering of the type III secretion machinery to induction of the type III secretion genes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Type VI secretion delivers bacteriolytic effectors to target cells
Russell, A. B., Hood, R. D., Bui, N. K., LeRoux, M., Vollmer, W., & Mougous, J. D. (2011) · Nature · doi:10.1038/nature10244 · Cited by 710
Paczkowski, J. E., Mukherjee, S., McCready, A. R., Cong, J.-P., Aquino, C. J., Kim, H., Henke, B. R., Smith, C. D., & Bassler, B. L. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.770552 · Cited by 319
Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system
Høyland-Kroghsbo, N. M., Paczkowski, J., Mukherjee, S., Broniewski, J., Westra, E., Bondy-Denomy, J., & Bassler, B. L. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617415113 · Cited by 312
Secreted transcription factor controls Mycobacterium tuberculosis virulence
Raghavan, S., Manzanillo, P., Chan, K., Dovey, C., & Cox, J. S. (2008) · Nature · doi:10.1038/nature07219 · Cited by 202
Kundracik, E., Trichka, J., Díaz Aponte, J., Roistacher, A., & Rietsch, A. (2022) · mBio · doi:10.1128/mbio.02381-22 · Cited by 18
Self-citation
Metadata
- Authors
- Rietsch, A., Vallet-Gely, I., Dove, S. L., & Mekalanos, J. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-05-23
- Volume
- 102
- Issue
- 22
- Pages
- 8006-8011
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2074044150
- Cited by
- 374
- References
- 0
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa. https://app.cochat.ai/papers/10.1073/pnas.0503005102
- The paper
- Rietsch, A., Vallet-Gely, I., Dove, S. L., & Mekalanos, J. J. (2005). ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0503005102
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
