Secreted transcription factor controls Mycobacterium tuberculosis virulence

Raghavan, Sridharan; Manzanillo, Paolo; Chan, Kaman; Dovey, Cole; Cox, Jeffery S.

doi:10.1038/nature07219

Cited by 202Tuberculosis Research and EpidemiologyBacterial Genetics and BiotechnologyEscherichia coli research studies

Secreted transcription factor controls Mycobacterium tuberculosis virulence

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Raghavan, Sridharan, Manzanillo, Paolo, Chan, Kaman, Dovey, Cole, Cox, Jeffery S.·2008·Nature

DOI 10.1038/nature07219PMC PMC2862998

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Abstract

Bacterial pathogens trigger specialized virulence factor secretion systems on encountering host cells. The ESX-1 protein secretion system of Mycobacterium tuberculosis-the causative agent of the human disease tuberculosis-delivers bacterial proteins into host cells during infection and is critical for virulence, but how it is regulated is unknown. Here we show that EspR (also known as Rv3849) is a key regulator of ESX-1 that is required for secretion and virulence in mice. EspR activates transcription of an operon that includes three ESX-1 components, Rv3616c-Rv3614c, whose expression in turn promotes secretion of ESX-1 substrates. EspR directly binds to and activates the Rv3616c-Rv3614c promoter and, unexpectedly, is itself secreted from the bacterial cell by the ESX-1 system that it regulates. Efflux of the DNA-binding regulator results in reduced Rv3616c-Rv3614c transcription, and thus reduced ESX-1 secretion. Our results reveal a direct negative feedback loop that regulates the activity of a secretion system essential for virulence. As the virulence factors secreted by the ESX-1 system are highly antigenic, fine control of secretion may be critical to successful infection.

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Four ESX-1 substrates have been identified in addition to ESAT-6 and CFP-10: EspA, EspB, EspR, and the M. marinum homologue of Rv3864.
“Thus far, four ESX-1 substrates have been identified in addition to ESAT-6 and CFP-10. These substrates are called EspA [39], EspB [46], EspR [41], and the M. marinum homologue of Rv3864 [22].”
From Systematic Genetic Nomenclature for Type VII Secretion Systems (2009) · cites this paper as [41]

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Authors: Raghavan, S., Manzanillo, P., Chan, K., Dovey, C., & Cox, J. S.
Affiliations: University of California, San Francisco (US)
Corresponding author: Cox, Jeffery S.
ORCID: Raghavan, Sridharan
Manzanillo, Paolo
Chan, Kaman
Cox, Jeffery S.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2008-08-07
Volume: 454
Issue: 7205
Pages: 717-721
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature07219
PMC: PMC2862998
OpenAlex: W1973827044
Cited by: 202
References: 42
Citations by year: 2026: 7 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 9 · 2019: 11 · 2018: 6 · 2017: 9 · 2016: 13 · 2015: 14 · 2014: 16 · 2013: 15 · 2012: 19
FWCI: 12.06
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: W. M. Keck Foundation
National Institutes of Health
National Institute of Allergy and Infectious Diseases (AI63302, AI51667, R01AI051667, P01AI063302)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Keywords: Mycobacterium tuberculosis, ESX-1 secretion system, transcriptional regulation, virulence factors, negative feedback loop, promoter activation, tuberculosis vaccine development, host-pathogen interaction
MeSH terms: Animals, Bacterial Proteins, Macrophages, Mice, Inbred C57BL, Mycobacterium tuberculosis, Operon, Promoter Regions, Genetic, Transcription Factors, Transcription, Genetic, Virulence, Transcriptional Activation, Gene Expression Regulation, Bacterial, Virulence Factors, Mice

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