The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system
Open accessAbstract
Significance: The cell–cell communication process, called quorum sensing, activates all three key aspects of the prokaryotic adaptive immune system (termed CRISPR-Cas): expression, activity, and adaptation in the pathogen Pseudomonas aeruginosa . We show that pro- and antiquorum-sensing compounds activate and repress CRISPR-Cas, respectively, suggesting the exciting possibility of a combination quorum-sensing–inhibition-phage therapy cocktail. In P. aeruginosa , quorum-sensing inhibitors repress virulence, making P. aeruginosa more susceptible to elimination by the human immune system, while simultaneously making P. aeruginosa more prone to killing by phage therapy through inhibition of the CRISPR-Cas defense mechanism. Finally, because we show that quorum sensing activates adaptation by the CRISPR-Cas immune system, a quorum-sensing inhibitor should also reduce acquisition of resistance against the administered phage.
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Cites
Enzymatic assembly of DNA molecules up to several hundred kilobases
Gibson, D. G., Young, L., Chuang, R.-Y., Venter, J. C., Hutchison, C. A., & Smith, H. O. (2009) · Nature Methods · doi:10.1038/nmeth.1318 · Cited by 9,996
CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes
Barrangou, R., Fremaux, C., Deveau, H., Richards, M., Boyaval, P., Moineau, S., Romero, D. A., & Horvath, P. (2007) · Science · doi:10.1126/science.1138140 · Cited by 5,947
Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes
Brouns, S. J. J., Jore, M. M., Lundgren, M., Westra, E. R., Slijkhuis, R. J. H., Snijders, A. P. L., Dickman, M. J., Makarova, K. S., Koonin, E. V., & van der Oost, J. (2008) · Science · doi:10.1126/science.1159689 · Cited by 2,460
Self-citationThe CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
Garneau, J. E., Dupuis, M.-È., Villion, M., Romero, D. A., Barrangou, R., Boyaval, P., Fremaux, C., Horvath, P., Magadán, A. H., & Moineau, S. (2010) · Nature · doi:10.1038/nature09523 · Cited by 2,328
Quorum sensing signal-response systems in Gram-negative bacteria
Papenfort, K., & Bassler, B. L. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.89 · Cited by 2,256
Self-citationCRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA
Marraffini, L. A., & Sontheimer, E. J. (2008) · Science · doi:10.1126/science.1165771 · Cited by 1,642
Short motif sequences determine the targets of the prokaryotic CRISPR defence system
Mojica, F. J. M., Díez-Villaseñor, C., García-Martínez, J., & Almendros, C. (2009) · Microbiology · doi:10.1099/mic.0.023960-0 · Cited by 1,426
Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa
Pesci, E. C., Pearson, J. P., Seed, P. C., & Iglewski, B. H. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.10.3127-3132.1997 · Cited by 889
Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system
Bondy-Denomy, J., Pawluk, A., Maxwell, K. L., & Davidson, A. R. (2013) · Nature · doi:10.1038/nature11723 · Cited by 830
Self-citationCRISPR-Cas immunity in prokaryotes
Marraffini, L. A. (2015) · Nature · doi:10.1038/nature15386 · Cited by 829
Cited by
The arms race between bacteria and their phage foes
Hampton, H. G., Watson, B. N. J., & Fineran, P. C. (2020) · Nature · doi:10.1038/s41586-019-1894-8 · Cited by 917
Paczkowski, J. E., Mukherjee, S., McCready, A. R., Cong, J.-P., Aquino, C. J., Kim, H., Henke, B. R., Smith, C. D., & Bassler, B. L. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.770552 · Cited by 319
Self-citationThe size of the immune repertoire of bacteria
Bradde, S., Nourmohammad, A., Goyal, S., & Balasubramanian, V. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903666117 · Cited by 52
Metadata
- Authors
- Høyland-Kroghsbo, N. M., Paczkowski, J., Mukherjee, S., Broniewski, J., Westra, E., Bondy-Denomy, J., & Bassler, B. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-11-14
- Volume
- 114
- Issue
- 1
- Pages
- 131-135
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2555970702
- Cited by
- 312
- References
- 48
- FWCI
- 11.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Høyland-Kroghsbo, N. M., Paczkowski, J., Mukherjee, S., Broniewski, J., Westra, E., Bondy-Denomy, J., & Bassler, B. L. (2017). Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1617415113
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