The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene
Open accessAbstract
Rearrangements of the RET receptor tyrosine kinase gene generating RET / PTC oncogenes are specific to papillary thyroid carcinoma (PTC), the most frequent thyroid tumor. Here, we show that the RET / PTC1 oncogene, when exogenously expressed in primary normal human thyrocytes, induces the expression of a large set of genes involved in inflammation and tumor invasion, including those encoding chemokines (CCL2, CCL20, CXCL8, and CXCL12), chemokine receptors (CXCR4), cytokines (IL1B, CSF-1, GM-CSF, and G-CSF), matrix-degrading enzymes (metalloproteases and urokinase-type plasminogen activator and its receptor), and adhesion molecules (L-selectin). This effect is strictly dependent on the presence of the RET/PTC1 Tyr-451 (corresponding to RET Tyr-1062 multidocking site). Selected relevant genes ( CCL20 , CCL2 , CXCL8 , CXCR4 , L-selectin , GM-CSF , IL1B , MMP9 , UPA , and SPP1 / OPN ) were found up-regulated also in clinical samples of PTC, particularly those characterized by RET / PTC activation, local extrathyroid spread, and lymph node metastases, when compared with normal thyroid tissue or follicular thyroid carcinoma. These results, demonstrating that the RET / PTC1 oncogene activates a proinflammatory program, provide a direct link between a transforming human oncogene, inflammation, and malignant behavior.
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Mantovani, A., Dinarello, C. A., Molgora, M., & Garlanda, C. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.012 · Cited by 1,046
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Propper, D. J., & Balkwill, F. R. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00588-9 · Cited by 989
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Metadata
- Authors
- Borrello, M. G., Alberti, L., Fischer, A., Degl'Innocenti, D., Ferrario, C., Gariboldi, M., Marchesi, F., Allavena, P., Greco, A., Collini, P., Pilotti, S., Cassinelli, G., Bressan, P., Fugazzola, L., Mantovani, A., & Pierotti, M. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-10-03
- Volume
- 102
- Issue
- 41
- Pages
- 14825-14830
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2114200189
- Cited by
- 331
- References
- 6
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Borrello, M. G., Alberti, L., Fischer, A., Degl'Innocenti, D., Ferrario, C., Gariboldi, M., Marchesi, F., Allavena, P., Greco, A., Collini, P., Pilotti, S., Cassinelli, G., Bressan, P., Fugazzola, L., Mantovani, A., & Pierotti, M. A. (2005). Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0503039102
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
