The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Soluble epoxide hydrolase is a therapeutic target for acute inflammation
Open accessAbstract
As of 2004, >73 million people were prescribed antiinflammatory medication. Despite the extensive number of current products, many people still suffer from their diseases or the pharmacological properties (side effects) of the medications. Therefore, developing therapeutic strategies to treat inflammation remains an important endeavor. Here, we demonstrate that the soluble epoxide hydrolase (sEH) is a key pharmacologic target for treating acute systemic inflammation. Lipopolysaccharide-induced mortality, systemic hypotension, and histologically evaluated tissue injury were substantially diminished by administration of urea-based, small-molecule inhibitors of sEH to C57BL/6 mice. Moreover, sEH inhibitors decreased plasma levels of proinflammatory cytokines and nitric oxide metabolites while promoting the formation of lipoxins, thus supporting inflammatory resolution. These data suggest that sEH inhibitors have therapeutic efficacy in the treatment and management of acute inflammatory diseases.
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Self-citationMarkov State Models with Weighted Ensemble Simulation: How to Eliminate the Trajectory Merging Bias
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Metadata
- Authors
- Schmelzer, K. R., Kubala, L., Newman, J. W., Kim, I.-H., Eiserich, J. P., & Hammock, B. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-06-30
- Volume
- 102
- Issue
- 28
- Pages
- 9772-9777
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1993788673
- Cited by
- 441
- References
- 18
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Schmelzer, K. R., Kubala, L., Newman, J. W., Kim, I.-H., Eiserich, J. P., & Hammock, B. D. (2005). Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0503279102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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