Cited by 130Genomics and Chromatin DynamicsNuclear Structure and FunctionEpigenetics and DNA Methylation

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Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing

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Huang, Shengbing, Zhou, Hui, Katzmann, David, Hochstrasser, Mark, Atanasova, Elena, Zhang, Zhiguo·2005·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0506176102PMC PMC1224646

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Abstract

Epigenetic inheritance of heterochromatin structure is an important cellular process whose mechanism remains elusive. In this article, we describe the identification of nine enhancers of the silencing defect of a Saccharomyces cerevisiae -PCNA mutant by screening a library of ≈4,700 viable yeast deletion mutants. Of the nine mutants identified, six ( hir1 , hir3 , sas2 , sas4 , sas5 , and sir1 ) were previously known to reduce silencing synergistically with a mutation in Cac1p, the large subunit of chromatin assembly factor 1 (CAF-1). The predicted gene products that are affected in three other mutants ( nam7 , msh2 , and rtt106 ) have not been implicated previously in silencing. Characterization of the rtt106 Δ allele revealed that it synergistically reduced heterochromatin silencing when combined with a mutation in Cac1p but not with a mutation in Asf1p (a histone H3 and H4 chaperone). Moreover, Rtt106p interacted with histones H3 and H4 both in vitro and in vivo , and it displayed a nucleosome assembly activity in vitro . Furthermore, Rtt106p interacts with CAF-1 physically through Cac1p. These biochemical and genetic data indicate that Rtt106p is a previously uncharacterized histone chaperone connecting S phase to epigenetic inheritance.

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Authors: Huang, S., Zhou, H., Katzmann, D., Hochstrasser, M., Atanasova, E., & Zhang, Z.
Affiliations: Mayo Clinic (US)
ORCID: Zhou, Hui
Katzmann, David
Hochstrasser, Mark
Zhang, Zhiguo
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2005-09-12
Volume: 102
Issue: 38
Pages: 13410-13415
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0506176102
PMC: PMC1224646
OpenAlex: W2031481332
Cited by: 130
References: 64
Citations by year: 2026: 3 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 5 · 2014: 6 · 2013: 7 · 2012: 7
FWCI: 2.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Cancer Research UK
University of Toronto
National Institutes of Health
National Institute of General Medical Sciences (R01GM046904, R37GM046904, GM-46904)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: histone chaperone, heterochromatin silencing, epigenetic inheritance, CAF-1, nucleosome assembly, histone H3, histone H4, S phase, Saccharomyces cerevisiae, Sir proteins
MeSH terms: Histones, Ribonucleases, Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, S Phase, Gene Deletion, Proliferating Cell Nuclear Antigen, Molecular Chaperones, Gene Silencing, Saccharomyces cerevisiae Proteins, Chromatin Assembly and Disassembly, Epigenesis, Genetic

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Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing

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