The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria
Open accessAbstract
Genetic host factors play a substantial role in susceptibility to and severity of malaria, which continues to cause at least one million deaths per year. Recently, members of the toll-like receptor (TLR) family have been shown to be involved in recognition of the etiologic organism Plasmodium falciparum: The glycosylphosphatidylinositol anchor induces signaling in host cells via TLR-2 and -4, whereas hemozoin-induced immune activation involves TLR-9. Binding of microbial ligands to the respective TLRs triggers the release of proinflammatory cytokines via the TLR/IL-1 receptor (TIR) domain and may contribute to the host response in malaria, including cytokine induction and fever. In a case-control study among 870 Ghanaian children, we examined the influence of TLR-2,-4, and-9 polymorphisms in susceptibility to severe malaria.TLR-2 variants common in Caucasians and Asians were completely absent. However, we found a rare previously undescribed mutation (Leu658Pro), which impairs signaling via TLR-2. We failed to detect any polymorphisms within the TLR-9 Toll/IL-1 receptor domain. Two frequent TLR-9 promoter polymorphisms did not show a clear association with malaria severity. In contrast, the TLR-4-Asp299Gly variant occurred at a high rate of 17.6% in healthy controls and was even more frequent in severe malaria patients (24.1%,P< 0.05). Likewise,TLR-4-Thr399Ile was seen in 2.4% of healthy children and in 6.2% of patients (P= 0.02).TLR-4-Asp299Gly and TLR-4-Thr399Ile conferred 1.5- and 2.6-fold increased risks of severe malaria, respectively. These findings suggest TLR4-mediated responses to malaria in vivo and TLR-4 polymorphisms to be associated with disease manifestation.
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TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
Kurt-Jones, E. A., Popova, L., Kwinn, L., Haynes, L. M., Jones, L. P., Tripp, R. A., Walsh, E. E., Freeman, M. W., Golenbock, D. T., Anderson, L. J., et al. (2000) · Nature Immunology · doi:10.1038/80833 · Cited by 1,683
Inferences, questions and possibilities in Toll-like receptor signalling
Beutler, B. (2004) · Nature · doi:10.1038/nature02761 · Cited by 1,466
Innate immune sensing and its roots: the story of endotoxin
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A Molecular Marker for Chloroquine-Resistant Falciparum Malaria
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Cited by
Into the Eye of the Cytokine Storm
Tisoncik, J. R., Korth, M. J., Simmons, C. P., Farrar, J., Martin, T. R., & Katze, M. G. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05015-11 · Cited by 1,940
Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation
Bochud, P.-Y., Chien, J. W., Marr, K. A., Leisenring, W. M., Upton, A., Janer, M., Rodrigues, S. D., Li, S., Hansen, J. A., Zhao, L. P., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802629 · Cited by 453
Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors
Matsushima, N., Tanaka, T., Enkhbayar, P., Mikami, T., Taga, M., Yamada, K., & Kuroki, Y. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-124 · Cited by 393
Toll-like receptor polymorphisms and susceptibility to human disease
Misch, E. A., & Hawn, T. R. (2008) · Clinical Science · doi:10.1042/cs20070214 · Cited by 263
Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome
Sharma, S., DeOliveira, R. B., Kalantari, P., Parroche, P., Goutagny, N., Jiang, Z., Chan, J., Bartholomeu, D. C., Lauw, F., Hall, J. P., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.016 · Cited by 262
Metadata
- Authors
- Mockenhaupt, F. P., Cramer, J. P., Hamann, L., Stegemann, M. S., Eckert, J., Oh, N.-R., Otchwemah, R. N., Dietz, E., Ehrhardt, S., Schröder, N. W. J., Bienzle, U., & Schumann, R. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-12-21
- Volume
- 103
- Issue
- 1
- Pages
- 177-182
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2172258104
- Cited by
- 320
- References
- 62
- FWCI
- 21.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Mockenhaupt, F. P., Cramer, J. P., Hamann, L., Stegemann, M. S., Eckert, J., Oh, N.-R., Otchwemah, R. N., Dietz, E., Ehrhardt, S., Schröder, N. W. J., Bienzle, U., & Schumann, R. R. (2006). Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0506803102
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