The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Progression of primary pneumonic plague: A mouse model of infection, pathology, and bacterial transcriptional activity
Open accessAbstract
Although pneumonic plague is the deadliest manifestation of disease caused by the bacterium Yersinia pestis , there is surprisingly little information on the cellular and molecular mechanisms responsible for Y. pestis -triggered pathology in the lung. Therefore, to understand the progression of this unique disease, we characterized an intranasal mouse model of primary pneumonic plague. Mice succumbed to a purulent multifocal severe exudative bronchopneumonia that closely resembles the disease observed in humans. Analyses revealed a strikingly biphasic syndrome, in which the infection begins with an antiinflammatory state in the first 24-36 h that rapidly progresses to a highly proinflammatory state by 48 h and death by 3 days. To assess the adaptation of Y. pestis to a mammalian environment, we used DNA microarray technology to analyze the transcriptional responses of the bacteria during interaction with the mouse lung. Included among the genes up-regulated in vivo are those comprising the yop-ysc type III secretion system and genes contained within the chromosomal pigmentation locus, validating the use of this technology to identify loci essential to the virulence of Y. pestis .
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Cites
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Cited by
A Plasminogen-Activating Protease Specifically Controls the Development of Primary Pneumonic Plague
Lathem, W. W., Price, P. A., Miller, V. L., & Goldman, W. E. (2007) · Science · doi:10.1126/science.1137195 · Cited by 275
Self-citationThewes, S., Kretschmar, M., Park, H., Schaller, M., Filler, S. G., & Hube, B. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05614.x · Cited by 140
Early Host Cell Targets of Yersinia pestis during Primary Pneumonic Plague
Pechous, R. D., Sivaraman, V., Price, P. A., Stasulli, N. M., & Goldman, W. E. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003679 · Cited by 90
Self-citationHunger for iron: the alternative siderophore iron scavenging systems in highly virulent Yersinia
Rakin, A., Schneider, L., & Podladchikova, O. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00151 · Cited by 89
Price, S. L., Vadyvaloo, V., DeMarco, J. K., Brady, A., Gray, P. A., Kehl-Fie, T. E., Garneau-Tsodikova, S., Perry, R. D., & Lawrenz, M. B. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2104073118 · Cited by 49
Metadata
- Authors
- Lathem, W. W., Crosby, S. D., Miller, V. L., & Goldman, W. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-11-23
- Volume
- 102
- Issue
- 49
- Pages
- 17786-17791
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2160502767
- Cited by
- 299
- References
- 20
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- green
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