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Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes
Open accessAbstract
The opportunistic pathogen Pseudomonas aeruginosa is responsible for a wide range of acute and chronic infections. The transition to chronic infections is accompanied by physiological changes in the bacteria favoring formation of biofilm communities. Here we report the identification of LadS, a hybrid sensor kinase that controls the reciprocal expression of genes for type III secretion and biofilm-promoting polysaccharides. Domain organization of LadS and the range of LadS-controlled genes suggest that it counteracts the activities of another sensor kinase, RetS. These two pathways converge by controlling the transcription of a small regulatory RNA, RsmZ. This work identifies a previously undescribed signal transduction network in which the activities of signal-receiving sensor kinases LadS, RetS, and GacS regulate expression of virulence genes associated with acute or chronic infection by transcriptional and posttranscriptional mechanisms.
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Citations
Cited by
Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms
Karatan, E., & Watnick, P. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00041-08 · Cited by 1,048
Determination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmA
Brencic, A., & Lory, S. (2009) · Molecular Microbiology · doi:10.1111/j.1365-2958.2009.06670.x · Cited by 346
Self-citationGooderham, W. J., & Hancock, R. E. W. (2009) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00135.x · Cited by 346
Regulation of Bacterial Virulence by Csr (Rsm) Systems
Vakulskas, C. A., Potts, A. H., Babitzke, P., Ahmer, B. M. M., & Romeo, T. (2015) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00052-14 · Cited by 346
Moscoso, J. A., Mikkelsen, H., Heeb, S., Williams, P., & Filloux, A. (2011) · Environmental Microbiology · doi:10.1111/j.1462-2920.2011.02595.x · Cited by 284
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Metadata
- Authors
- Ventre, I., Goodman, A. L., Vallet-Gely, I., Vasseur, P., Soscia, C., Molin, S., Bleves, S., Lazdunski, A., Lory, S., & Filloux, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-12-22
- Volume
- 103
- Issue
- 1
- Pages
- 171-176
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1964112944
- Cited by
- 428
- References
- 0
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Ventre, I., Goodman, A. L., Vallet-Gely, I., Vasseur, P., Soscia, C., Molin, S., Bleves, S., Lazdunski, A., Lory, S., & Filloux, A. (2006). Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0507407103
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