The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Real-time imaging of the somite segmentation clock: Revelation of unstable oscillators in the individual presomitic mesoderm cells
Open accessAbstract
Notch signaling components such as the basic helix-loop-helix gene Hes1 are cyclically expressed by negative feedback in the presomitic mesoderm (PSM) and constitute the somite segmentation clock. Because Hes1 oscillation occurs in many cell types, this clock may regulate the timing in many biological systems. Although the Hes1 oscillator is stable in the PSM, it damps rapidly in other cells, suggesting that the oscillators in the former and the latter could be intrinsically different. Here, we have established the real-time bioluminescence imaging system of Hes1 expression and found that, although Hes1 oscillation is robust and stable in the PSM, it is unstable in the individual dissociated PSM cells, as in fibroblasts. Thus, the Hes1 oscillators in the individual PSM cells and fibroblasts are intrinsically similar, and these results, together with mathematical simulation, suggest that cell-cell communication is essential not only for synchronization but also for stabilization of cellular oscillators.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Palmeirim, I., Henrique, D., Ish-Horowicz, D., & Pourquié, O. (1997) · Cell · doi:10.1016/s0092-8674(00)80451-1 · Cited by 948
Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus
Yamaguchi, S., Isejima, H., Matsuo, T., Okura, R., Yagita, K., Kobayashi, M., & Okamura, H. (2003) · Science · doi:10.1126/science.1089287 · Cited by 931
Self-citationOscillatory Expression of the bHLH Factor Hes1 Regulated by a Negative Feedback Loop
Hirata, H., Yoshiura, S., Ohtsuka, T., Bessho, Y., Harada, T., Yoshikawa, K., & Kageyama, R. (2002) · Science · doi:10.1126/science.1074560 · Cited by 763
Self-citationAutoinhibition with Transcriptional Delay
Lewis, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00534-7 · Cited by 746
Oscillatory Expression of Hes1, p53, and NF-κB Driven by Transcriptional Time Delays
Monk, N. A. M. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00494-9 · Cited by 708
Notch signalling and the synchronization of the somite segmentation clock
Jiang, Y.-J., Aerne, B. L., Smithers, L., Haddon, C., Ish-Horowicz, D., & Lewis, J. (2000) · Nature · doi:10.1038/35044091 · Cited by 538
The Segmentation Clock: Converting Embryonic Time into Spatial Pattern
Pourquié, O. (2003) · Science · doi:10.1126/science.1085887 · Cited by 523
Dynamic expression and essential functions of Hes7 in somite segmentation
Bessho, Y., Sakata, R., Komatsu, S., Shiota, K., Yamada, S., & Kageyama, R. (2001) · Genes & Development · doi:10.1101/gad.930601 · Cited by 364
Self-citationJouve, C., Palmeirim, I., Henrique, D., Beckers, J., Gossler, A., Ish-Horowicz, D., & Pourquié, O. (2000) · Development · doi:10.1242/dev.127.7.1421 · Cited by 331
Periodic Notch inhibition by Lunatic Fringe underlies the chick segmentation clock
Dale, J. K., Maroto, M., Dequeant, M.-L., Malapert, P., McGrew, M., & Pourquie, O. (2003) · Nature · doi:10.1038/nature01244 · Cited by 321
Cited by
Intercellular Coupling Confers Robustness against Mutations in the SCN Circadian Clock Network
Liu, A. C., Welsh, D. K., Ko, C. H., Tran, H. G., Zhang, E. E., Priest, A. A., Buhr, E. D., Singer, O., Meeker, K., Verma, I. M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.02.047 · Cited by 699
bHLH Factors in Self-Renewal, Multipotency, and Fate Choice of Neural Progenitor Cells
Imayoshi, I., & Kageyama, R. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.018 · Cited by 278
Self-citationCohen, M., Georgiou, M., Stevenson, N. L., Miodownik, M., & Baum, B. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.006 · Cited by 272
Synchrony Dynamics During Initiation, Failure, and Rescue of the Segmentation Clock
Riedel-Kruse, I. H., Müller, C., & Oates, A. C. (2007) · Science · doi:10.1126/science.1142538 · Cited by 268
Species-specific segmentation clock periods are due to differential biochemical reaction speeds
Matsuda, M., Hayashi, H., Garcia-Ojalvo, J., Yoshioka-Kobayashi, K., Kageyama, R., Yamanaka, Y., Ikeya, M., Toguchida, J., Alev, C., & Ebisuya, M. (2020) · Science · doi:10.1126/science.aba7668 · Cited by 254
Self-citation
Metadata
- Authors
- Masamizu, Y., Ohtsuka, T., Takashima, Y., Nagahara, H., Takenaka, Y., Yoshikawa, K., Okamura, H., & Kageyama, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-01-23
- Volume
- 103
- Issue
- 5
- Pages
- 1313-1318
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2106921662
- Cited by
- 351
- References
- 27
- FWCI
- 11.66
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Real-time imaging of the somite segmentation clock: Revelation of unstable oscillators in the individual presomitic mesoderm cells. https://app.cochat.ai/papers/10.1073/pnas.0508658103
- The paper
- Masamizu, Y., Ohtsuka, T., Takashima, Y., Nagahara, H., Takenaka, Y., Yoshikawa, K., Okamura, H., & Kageyama, R. (2006). Real-time imaging of the somite segmentation clock: Revelation of unstable oscillators in the individual presomitic mesoderm cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0508658103
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
