The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus
Abstract
Individual cellular clocks in the suprachiasmatic nucleus (SCN), the circadian center, are integrated into a stable and robust pacemaker with a period length of about 24 hours. We used real-time analysis of gene expression to show synchronized rhythms of clock gene transcription across hundreds of neurons within the mammalian SCN in organotypic slice culture. Differentially phased neuronal clocks are topographically arranged across the SCN. A protein synthesis inhibitor set all cell clocks to the same initial phase and, after withdrawal, intrinsic interactions among cell clocks reestablished the stable program of gene expression across the assemblage. Na + -dependent action potentials contributed to establishing cellular synchrony and maintaining spontaneous oscillation across the SCN.
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Cites
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
CIRCADIAN RHYTHMS: Basic Neurobiology and Clinical Applications
Moore MD, R. Y. (1997) · Annual Review of Medicine · doi:10.1146/annurev.med.48.1.253 · Cited by 400
Cited by
Central and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265
Suprachiasmatic Nucleus: Cell Autonomy and Network Properties
Welsh, D. K., Takahashi, J. S., & Kay, S. A. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135919 · Cited by 1,216
Generation of circadian rhythms in the suprachiasmatic nucleus
Hastings, M. H., Maywood, E. S., & Brancaccio, M. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0026-z · Cited by 1,065
Mammalian circadian biology: elucidating genome-wide levels of temporal organization
Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976
Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators
Buhr, E. D., Yoo, S.-H., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195262 · Cited by 917
Metadata
- Authors
- Yamaguchi, S., Isejima, H., Matsuo, T., Okura, R., Yagita, K., Kobayashi, M., & Okamura, H.
- Venue
- Science
- Published
- 2003-11-21
- Volume
- 302
- Issue
- 5649
- Pages
- 1408-1412
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2082433800
- Cited by
- 931
- References
- 2
- FWCI
- 12.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yamaguchi, S., Isejima, H., Matsuo, T., Okura, R., Yagita, K., Kobayashi, M., & Okamura, H. (2003). Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus. Science. https://doi.org/10.1126/science.1089287
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