Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3

Transcription factor GATA-3 is required for development of the T-cell lineage

Ting, C.-N., Olson, M. C., Barton, K., & Leiden, J. M. (1996) · Nature · doi:10.1038/384474a0 · Cited by 607 · see citing works

Transcription Factor GATA-2 Is Required for Proliferation/Survival of Early Hematopoietic Cells and Mast Cell Formation, But Not for Erythroid and Myeloid Terminal Differentiation

Tsai, F., & Orkin, S. H. (1997) · Blood · doi:10.1182/blood.v89.10.3636.3636_3636_3643 · Cited by 596 · see citing works

Thymopoiesis independent of common lymphoid progenitors.

Allman, D., Sambandam, A., Kim, S., Miller, J. P., Pagan, A., Well, D., Meraz, A., & Bhandoola, A. (2003) · Nature Immunology · doi:10.1038/ni878 · Cited by 544 · see citing works

GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors

Zhu, J., Yamane, H., Cote-Sierra, J., Guo, L.-Y., & Paul, W. (2006) · Cell Research · doi:10.1038/sj.cr.7310002 · Cited by 497 · see citing works

Transcription from the RAG1 Locus Marks the Earliest Lymphocyte Progenitors in Bone Marrow

Igarashi, H., Gregory, S. C., Yokota, T., Sakaguchi, N., & Kincade, P. W. (2002) · Immunity · doi:10.1016/s1074-7613(02)00366-7 · Cited by 452 · see citing works

Identification of a Committed Precursor for the Mast Cell Lineage

Rodewald, H.-R., Dessing, M., Dvořàk, A. M., & Galli, S. J. (1996) · Science · doi:10.1126/science.271.5250.818 · Cited by 376 · see citing works

GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling

Grass, J. A., Boyer, M. E., Pal, S. K., Wu, J., Weiss, M. J., & Bresnick, E. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432147100 · Cited by 357 · see citing works

Reprogramming of Committed T Cell Progenitors to Macrophages and Dendritic Cells by C/EBPα and PU.1 Transcription Factors

Laiosa, C. V., Stadtfeld, M., Xie, H., de Andres-Aguayo, L., & Graf, T. (2006) · Immunity · doi:10.1016/j.immuni.2006.09.011 · Cited by 351 · see citing works

Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis

Arinobu, Y., Iwasaki, H., Gurish, M. F., Mizuno, S.-I., Shigematsu, H., Ozawa, H., Tenen, D. G., Austen, K. F., & Akashi, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509148102 · Cited by 340 · see citing works

Maintenance of T Cell Specification and Differentiation Requires Recurrent Notch Receptor–Ligand Interactions

Schmitt, T. M., Ciofani, M., Petrie, H. T., & Zúñiga‐Pflücker, J. C. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040394 · Cited by 328 · see citing works

T-cell development made simple

Zúñiga‐Pflücker, J. C. (2004) · Nature reviews. Immunology · doi:10.1038/nri1257 · Cited by 325 · see citing works

The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages.Preprint

Iwasaki, H., Mizuno, S., Arinobu, Y., Ozawa, H., Mori, Y., Shigematsu, H., Takatsu, K., Tenen, D., & Akashi, K. (2006) · Genes & Development · doi:10.1101/gad.1493506 · Cited by 313 · see citing works

Identification of mast cell progenitors in adult mice

Chen, C., Grimbaldeston, M. A., Tsai, M. M., Weissman, I. L., & Galli, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504197102 · Cited by 312 · see citing works

Critical Roles for Transcription Factor GATA-3 in Thymocyte Development

Pai, S., Truitt, M., Ting, C.-N., Leiden, J. M., Glimcher, L. H., & Ho, I. (2003) · Immunity · doi:10.1016/s1074-7613(03)00328-5 · Cited by 312 · see citing works

Developmental and Molecular Characterization of Emerging β- and γδ-Selected Pre-T Cells in the Adult Mouse Thymus

Taghon, T., Yui, M. A., Pant, R., Diamond, R. A., & Rothenberg, E. V. (2006) · Immunity · doi:10.1016/j.immuni.2005.11.012 · Cited by 312 · see citing works

Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates

Walsh, J. C., DeKoter, R. P., Lee, H.-J., Smith, E. D., Lancki, D. W., Gurish, M. F., Friend, D. S., Stevens, R. L., Anastasi, J., & Singh, H. (2002) · Immunity · doi:10.1016/s1074-7613(02)00452-1 · Cited by 262 · see citing works

DETERMINANTS OF LYMPHOID-MYELOID LINEAGE DIVERSIFICATION

Laiosa, C. V., Stadtfeld, M., & Graf, T. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090742 · Cited by 260 · see citing works

MOLECULAR GENETICS OF T CELL DEVELOPMENT

Rothenberg, E. V., & Taghon, T. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115737 · Cited by 256 · see citing works

GATA-3 Expression Is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation

Hernández‐Hoyos, G., Anderson, M. K., Wang, C., Rothenberg, E. V., & Alberola‐Ila, J. (2003) · Immunity · doi:10.1016/s1074-7613(03)00176-6 · Cited by 254 · see citing works

GATA-3 Promotes Maturation, IFN-γ Production, and Liver-Specific Homing of NK Cells

Samson, S., Richard, O., Tavian, M., Ranson, T., Vosshenrich, C. A. J., Colucci, F., Buer, J., Grosveld, F. G., Godin, I., & Santo, J. P. D. (2003) · Immunity · doi:10.1016/s1074-7613(03)00294-2 · Cited by 243 · see citing works

Growth Factor Independent-1 Induced by IL-4 Regulates Th2 Cell Proliferation

Zhu, J., Guo, L., Min, B., Watson, C. J., Hu‐Li, J., Young, H. A., Tsichlis, P. N., & Paul, W. E. (2002) · Immunity · doi:10.1016/s1074-7613(02)00317-5 · Cited by 217 · see citing works

The bHLH gene Hes1 is essential for expansion of early T cell precursorsPreprint

Tomita, K., Hattori, M., Nakamura, E., Nakanishi, S., Minato, N., & Kageyama, R. (1999) · Genes & Development · doi:10.1101/gad.13.9.1203 · Cited by 209 · see citing works

The earliest subpopulation of mouse thymocytes contains potent T, significant macrophage, and natural killer cell but no B-lymphocyte potential

Balciunaite, G., Ceredig, R., & Rolink, A. G. (2005) · Blood · doi:10.1182/blood-2004-08-3087 · Cited by 158 · see citing works

Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signalingPreprint

Taghon, T., David‐Fung, E., Zúñiga‐Pflücker, J. C., & Rothenberg, E. V. (2005) · Genes & Development · doi:10.1101/gad.1298305 · Cited by 154 · see citing works

Acetylation of GATA‐3 affects T‐cell survival and homing to secondary lymphoid organs

Yamagata, T., Mitani, K., Oda, H., Suzuki, T., Honda, H., Asai, T., Maki, K., Nakamoto, T., & Hirai, H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.17.4676 · Cited by 119 · see citing works

CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients

Speiser, D. E., Valmori, D., Rimoldi, D., Pittet, M. J., Líénard, D., Cerundolo, V., MacDonald, H. R., Cerottini, J., & Romero, P. J. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199906)29:06 · Cited by 119 · see citing works

The linkage between T‐cell and dendritic cell development in the mouse thymus

Shortman, K., Vremec, D., Corcoran, L. M., Georgopoulos, K., Lucas, K., & Wu, L. (1998) · Immunological Reviews · doi:10.1111/j.1600-065x.1998.tb01228.x · Cited by 117 · see citing works

A GATA Box in the GATA-1 Gene Hematopoietic Enhancer Is a Critical Element in the Network of GATA Factors and Sites That Regulate This Gene

Nishimura, S., Takahashi, S., Kuroha, T., Suwabe, N., Nagasawa, T., Trainor, C. D., & Yamamoto, M. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.2.713-723.2000 · Cited by 115 · see citing works

Notch/Delta signaling constrains reengineering of pro-T cells by PU.1

Franco, C. B., Scripture-Adams, D. D., Proekt, I., Taghon, T., Weiss, A. H., Yui, M. A., Adams, S. L., Diamond, R. A., & Rothenberg, E. V. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601188103 · Cited by 109 · see citing works

Analysis of Notch1 Function by In Vitro T Cell Differentiation of Pax5 Mutant Lymphoid Progenitors

Höflinger, S., Kesavan, K. P., Fuxa, M., Hutter, C., Heavey, B., Radtke, F., & Busslinger, M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3935 · Cited by 107 · see citing works

Cutting Edge: Three-Dimensional Architecture of the Thymus Is Required to Maintain Delta-Like Expression Necessary for Inducing T Cell Development

Mohtashami, M., & Zúñiga‐Pflücker, J. C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.730 · Cited by 101 · see citing works

Myeloid lineage switch of Pax5 mutant but not wild‐type B cell progenitors by C/EBPα and GATA factors

Heavey, B., Charalambous, C., Cobaleda, C., & Busslinger, M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg380 · Cited by 95 · see citing works

Enforced Expression of GATA-3 During T Cell Development Inhibits Maturation of CD8 Single-Positive Cells and Induces Thymic Lymphoma in Transgenic Mice

Nawijn, M. C., Ferreira, R., Dingjan, G. M., Kahre, O., Drabek, D., Karis, A., Grosveld, F. G., & Hendriks, R. W. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.2.715 · Cited by 94 · see citing works

Friend of GATA-1 Represses GATA-3–dependent Activity in CD4+ T Cells

Zhou, M., Ouyang, W., Gong, Q., Katz, S. G., White, J. M., Orkin, S. H., & MURPHY, K. M. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.10.1461 · Cited by 87 · see citing works

Definition of Regulatory Network Elements for T Cell Development by Perturbation Analysis with PU.1 and GATA-3

Anderson, M. K., Hernández‐Hoyos, G., Dionne, C. J., Arias, A. M., Chen, D., & Rothenberg, E. V. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0674 · Cited by 85 · see citing works

Notch Signals Inhibit the Development of Erythroid/Megakaryocytic Cells by Suppressing GATA-1 Activity through the Induction of HES1

Ishiko, E., Matsumura, I., Ezoe, S., Gale, K. B., Ishiko, J., Satoh, Y., Tanaka, H., Shibayama, H., Mizuki, M., Era, T., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406788200 · Cited by 80 · see citing works

Cutting Edge: The Differential Involvement of the N-Finger of GATA-3 in Chromatin Remodeling and Transactivation During Th2 Development

Takemoto, N., Arai, K., & Miyatake, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.8.4103 · Cited by 69 · see citing works

Enforced expression of the GATA-3 transcription factor affects cell fate decisions in hematopoiesis

Chen, D., & Zhang, G. (2001) · Experimental Hematology · doi:10.1016/s0301-472x(01)00670-1 · Cited by 68 · see citing works

Tumor necrosis factor-alpha and IFN-gamma expression in human thymus. Localization and overexpression in Down syndrome (trisomy 21)

Murphy, M., Friend, D., Pike-Nobile, L., & Epstein, L. B. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.7.2506 · Cited by 67 · see citing works

GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21WAF1 and p27Kip1 proteins

Ezoe, S. (2002) · Blood · doi:10.1182/blood-2002-04-1177 · Cited by 65 · see citing works

T/NK Bipotent Progenitors in the Thymus Retain the Potential to Generate Dendritic Cells

Shen, H. Q., Lu, M. M., Ikawa, T., Masuda, K., Ohmura, K., Minato, N., Katsura, Y., & Kawamoto, H. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3401 · Cited by 63 · see citing works

Progression of regulatory gene expression states in fetal and adult pro-T-cell development

David‐Fung, E., Yui, M. A., Morales, M., Wang, H., Taghon, T., Diamond, R. A., & Rothenberg, E. V. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00355.x · Cited by 60 · see citing works

Regulation of intrathymic T‐cell development by Lunatic Fringe– Notch1 interactions

Visan, I., Yuan, J. S., Tan, J. B. L., Cretegny, K., & Guidos, C. J. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00360.x · Cited by 58 · see citing works

The probable relationship of some or all mast cells to the T-cell system

Burnet, F. M. (1977) · Cellular Immunology · doi:10.1016/0008-8749(77)90079-x · Cited by 54 · see citing works

Enforced Expression of GATA-3 Severely Reduces Human Thymic Cellularity

Taghon, T., Smedt, M. D., Stolz, F., Cnockaert, M., Plum, J. R., & Leclercq, G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.8.4468 · Cited by 39 · see citing works

The transcription factor profile of human mast cells in comparison with monocytes and granulocytes

Babina, M., Sch�lke, Y., Kirchhof, L., Guhl, S., Franke, R., B�hm, S., Zuberbier, T., Henz, B. M., & Gombart, A. F. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4480-6 · Cited by 34 · see citing works

GATA-1 is required for expression of FcεRI on mast cells: analysis of mast cells derived from GATA-1 knockdown mouse bone marrow

Nishiyama, C., Ito, T., Nishiyama, M., Masaki, S., Maeda, K., Nakano, N., Ng, W., Fukuyama, K., Yamamoto, M. P., Okumura, K., et al. (2005) · International Immunology · doi:10.1093/intimm/dxh278 · Cited by 33 · see citing works

The thymus is a site of mast cell development in chicken embryos

Enrico Crivellato, B., Nico, B., Battistig, M., Beltrami, C. A., & Ribatti, D. (2004) · Anatomy and Embryology · doi:10.1007/s00429-004-0439-5 · Cited by 26 · see citing works

Severe combined immunodeficiency with thymic mast cell hyperplasia.

Ws, W., Wj, S., & Vv, J. (1976) · PubMed · Cited by 3 · see citing works

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

Orkin, S. H., & Zon, L. I. (2008) · Cell · doi:10.1016/j.cell.2008.01.025 · Cited by 2,570 · see citing works

Launching the T-cell-lineage developmental programme

Rothenberg, E. V., Moore, J. E., & Yui, M. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2232 · Cited by 475 · see citing works

GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation

Ho, I., Tai, T.-S., & Pai, S. (2009) · Nature reviews. Immunology · doi:10.1038/nri2476 · Cited by 425 · see citing works

T-cell regulation in chronic paranasal sinus disease

Bruaene, N. V., Perez-Novo, C. A., Basinski, T. M., Zele, T. V., Holtappels, G., Ruyck, N. D., Schmidt‐Weber, C. B., Akdiş, C. A., Cauwenberge, P. V., Bachert, C., et al. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.02.018 · Cited by 351 · see citing works

Developmental gene networks: a triathlon on the course to T cell identity

Yui, M. A., & Rothenberg, E. V. (2014) · Nature Reviews Immunology · doi:10.1038/nri3702 · Cited by 342 · see citing works

Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity

Zhang, J. A., Mortazavi, A., Williams, B. A., Wold, B. J., & Rothenberg, E. V. (2012) · Cell · doi:10.1016/j.cell.2012.01.056 · Cited by 337 · see citing works

Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors

Riddell, J., Gazit, R., Garrison, B. S., Guo, G., Saadatpour, A., Mandal, P. K., Ebina, W., Volchkov, P., Yuan, G.-C., Orkin, S. H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.006 · Cited by 323 · see citing works

Mast cell progenitors: Origin, development and migration to tissues

Dahlin, J. S., & Hallgren, J. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.01.018 · Cited by 318 · see citing works

GATA3 in development and cancer differentiation: Cells GATA have it!

Chou, J., Provot, S., & Werb, Z. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21943 · Cited by 304 · see citing works

Mechanisms of T Cell Development and Transformation

Koch, U., & Radtke, F. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154008 · Cited by 282 · see citing works

GATA-3 Function in Innate and Adaptive Immunity

Tindemans, I., Serafini, N., Santo, J. P. D., & Hendriks, R. W. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.006 · Cited by 258 · see citing works

How transcription factors drive choice of the T cell fate

Hosokawa, H., & Rothenberg, E. V. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-00426-6 · Cited by 239 · see citing works

T Cell Factor 1 Is Required for Group 2 Innate Lymphoid Cell Generation

Yang, Q., Monticelli, L. A., Saenz, S. A., Chi, A. W.-S., Sonnenberg, G. F., Tang, J.-B., Obaldia, M. E. D., Bailis, W., Bryson, J. L., Toscano, K., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.003 · Cited by 244 · see citing works

Transcriptional Control of Early T and B Cell Developmental Choices

Rothenberg, E. V. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100024 · Cited by 232 · see citing works

Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5 + and IL-13 + type 2 innate lymphoid cells

Wolterink, R. G. J. K., Serafini, N., van Nimwegen, M., Vosshenrich, C. A. J., de Bruijn, M. J. W., Fonseca‐Pereira, D., Veiga‐Fernandes, H., Hendriks, R. W., & Santo, J. P. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217158110 · Cited by 226 · see citing works

Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice

Lilla, J. N., Chen, C., Mukai, K., BenBarak, M. J., Franco, C. B., Kalesnikoff, J., Yu, M., Tsai, M. M., Piliponsky, A. M., & Galli, S. J. (2011) · Blood · doi:10.1182/blood-2011-03-343962 · Cited by 217 · see citing works

Redefinition of the human mast cell transcriptome by deep-CAGE sequencing

Motakis, E., Guhl, S., Ishizu, Y., Itoh, M., Kawaji, H., de Hoon, M., Lassmann, T., Carninci, P., Hayashizaki, Y., Zuberbier, T., et al. (2014) · Blood · doi:10.1182/blood-2013-02-483792 · Cited by 211 · see citing works

New models for analyzing mast cell functions in vivo

Reber, L. L., Marichal, T., & Galli, S. J. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.09.008 · Cited by 188 · see citing works

Functions of Notch Signaling in the Immune System: Consensus and Controversies

Yuan, J. S., Kousis, P. C., Suliman, S., Visan, I., & Guidos, C. J. (2010) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132719 · Cited by 178 · see citing works

Deletion of Notch1 Converts Pro-T Cells to Dendritic Cells and Promotes Thymic B Cells by Cell-Extrinsic and Cell-Intrinsic Mechanisms

Feyerabend, T. B., Terszowski, G., Tietz, A., Blum, C., Luche, H., Gossler, A., Gale, N. W., Radtke, F., Fehling, H. J., & Rodewald, H.-R. (2008) · Immunity · doi:10.1016/j.immuni.2008.10.016 · Cited by 177 · see citing works

Transcriptional Regulation of Innate and Adaptive Lymphocyte Lineages

Obaldia, M. E. D., & Bhandoola, A. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112032 · Cited by 163 · see citing works

From the cradle to the grave: activities of GATA‐3 throughout T‐cell development and differentiation

Hosoya, T., Maillard, I. P., & Engel, J. D. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00954.x · Cited by 157 · see citing works

GATA-3 is required for early T lineage progenitor development

Hosoya, T., Kuroha, T., Moriguchi, T., Cummings, D. R., Maillard, I. P., Lim, K.-C., & Engel, J. D. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090934 · Cited by 154 · see citing works

Fine-Scale Staging of T Cell Lineage Commitment in Adult Mouse Thymus

Yui, M. A., Feng, N., & Rothenberg, E. V. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000679 · Cited by 152 · see citing works

Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages

Zhou, Y., Yu, X., Chen, H., Sjöberg, S., Roux, J., Zhang, L., Ivoulsou, A.-H., Bensaid, F., Liu, C.-L., Liu, J., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.013 · Cited by 137 · see citing works

Adipose Tissue as a Dedicated Reservoir of Functional Mast Cell Progenitors

Poglio, S., de Toni, F., Arnaud, E., Laharrague, P. F., Espinosa, É., Casteilla, L., & Cousin, B. (2010) · Stem Cells · doi:10.1002/stem.523 · Cited by 123 · see citing works

De novo generation of HSCs from somatic and pluripotent stem cell sources

Vo, L. T., & Daley, G. Q. (2015) · Blood · doi:10.1182/blood-2014-10-570234 · Cited by 119 · see citing works

A far downstream enhancer for murine Bcl11b controls its T-cell specific expression

Li, L., Zhang, J. A., Dose, M., Kueh, H. Y., Mosadeghi, R., Gounari, F., & Rothenberg, E. V. (2013) · Blood · doi:10.1182/blood-2012-08-447839 · Cited by 115 · see citing works

Transcription factor PU.1 represses and activates gene expression in early T cells by redirecting partner transcription factor binding

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T., & Rothenberg, E. V. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.024 · Cited by 116 · see citing works

Intrathymic proliferation wave essential for Vα14 + natural killer T cell development depends on c-Myc

Dose, M., Sleckman, B. P., Han, J., Bredemeyer, A. L., Bendelac, A. S., & Gounari, F. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812255106 · Cited by 110 · see citing works

Approaches for Analyzing the Roles of Mast Cells and Their Proteases In Vivo

Galli, S. J., Tsai, M. M., Marichal, T., Tchougounova, E., Reber, L. L., & Pejler, G. (2015) · Advances in immunology · doi:10.1016/bs.ai.2014.11.002 · Cited by 105 · see citing works

GATA-3 promotes T-cell specification by repressing B-cell potential in pro–T cells in mice

García‐Ojeda, M. E., Wolterink, R. G. J. K., Lemaı̂tre, F., Goff, O. R.-L., Hasan, M., Hendriks, R. W., Cumano, A., & Santo, J. P. D. (2013) · Blood · doi:10.1182/blood-2012-06-440065 · Cited by 105 · see citing works

T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1

Obaldia, M. E. D., Bell, J. J., Wang, X., Harly, C., Yashiro–Ohtani, Y., DeLong, J. H., Zlotoff, D. A., Sultana, D. A., Pear, W. S., & Bhandoola, A. (2013) · Nature Immunology · doi:10.1038/ni.2760 · Cited by 101 · see citing works

Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development

Rothenberg, E. V., Hosokawa, H., & Ungerbäck, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00228 · Cited by 99 · see citing works

Architecture of a lymphomyeloid developmental switch controlled by PU.1, Notch and Gata3

Del Real, M. M., & Rothenberg, E. V. (2013) · Development · doi:10.1242/dev.088559 · Cited by 95 · see citing works

A gene regulatory network armature for T lymphocyte specification

Georgescu, C., Longabaugh, W. J. R., Scripture-Adams, D. D., David‐Fung, E., Yui, M. A., Zarnegar, M. A., Bolouri, H., & Rothenberg, E. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806501105 · Cited by 95 · see citing works

Transcriptional Regulation of Gata3 in T Helper Cells by the Integrated Activities of Transcription Factors Downstream of the Interleukin-4 Receptor and T Cell Receptor

Scheinman, E. J., & Avni, O. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807302200 · Cited by 93 · see citing works

Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network

Longabaugh, W. J. R., Zeng, W., Zhang, J. A., Hosokawa, H., Jansen, C. S., Li, L., Romero-Wolf, M., Liu, P., Kueh, H. Y., Mortazavi, A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610617114 · Cited by 89 · see citing works

T Cell Lineage Commitment: Identity and Renunciation

Rothenberg, E. V. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003703 · Cited by 90 · see citing works

RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus

Ferreira, A. C. F., Szeto, A. C. H., Heycock, M. W. D., Clark, P. A., Walker, J. A., Crisp, A., Barlow, J. L., Kitching, S., Lim, A., Gogoi, M., et al. (2021) · Nature Immunology · doi:10.1038/s41590-020-00833-w · Cited by 87 · see citing works

Negotiation of the T Lineage Fate Decision by Transcription-Factor Interplay and Microenvironmental Signals

Rothenberg, E. V. (2007) · Immunity · doi:10.1016/j.immuni.2007.06.005 · Cited by 83 · see citing works

Multilayered specification of the T-cell lineage fate.

Rothenberg, E. V., Zhang, J., & Li, L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00964.x · Cited by 81 · see citing works

GATA-3 Dose-Dependent Checkpoints in Early T Cell Commitment

Scripture-Adams, D. D., Damle, S. S., Li, L., Elihu, K. J., Qin, S., Arias, A. M., Butler, R. R., Champhekar, A., Zhang, J. A., & Rothenberg, E. V. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301663 · Cited by 81 · see citing works

Transcriptional drivers of the T-cell lineage program

Rothenberg, E. V. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.12.012 · Cited by 80 · see citing works

Cytokines, Transcription Factors, and the Initiation of T-Cell DevelopmentPreprint

Hosokawa, H., & Rothenberg, E. V. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028621 · Cited by 79 · see citing works

Regulation of Notch signaling during T‐ and B‐cell development by O‐fucose glycans

Stanley, P., & Guidos, C. J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00791.x · Cited by 80 · see citing works

The Development of T Cells From Stem Cells in Mice and Humans

Famili, F., Wiekmeijer, A., & Staal, F. J. T. (2017) · Future Science OA · doi:10.4155/fsoa-2016-0095 · Cited by 76 · see citing works

E proteins and the regulation of early lymphocyte development

de Pooter, R. F., & Kee, B. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00957.x · Cited by 77 · see citing works

An Overview of Notch Signaling in Adult Tissue Renewal and Maintenance

Sato, C., Zhao, G., & Ilagan, M. X. G. (2012) · Current Alzheimer Research · doi:10.2174/156720512799361600 · Cited by 79 · see citing works

Programming for T-lymphocyte fates: modularity and mechanismsPreprint

Rothenberg, E. V. (2019) · Genes & Development · doi:10.1101/gad.327163.119 · Cited by 74 · see citing works

Regulation of early T-lineage gene expression and developmental progression by the progenitor cell transcription factor PU.1

Champhekar, A., Damle, S. S., Freedman, G., Carotta, S., Nutt, S. L., & Rothenberg, E. V. (2015) · Genes & Development · doi:10.1101/gad.259879.115 · Cited by 74 · see citing works

E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment

Xu, W., Carr, T. M., Ramirez, K., McGregor, S. M., Sigvardsson, M., & Kee, B. L. (2013) · Blood · doi:10.1182/blood-2012-08-449447 · Cited by 73 · see citing works

Transcriptional Repression of Gata3 Is Essential for Early B Cell Commitment

Banerjee, A., Northrup, D. L., Boukarabila, H., Jacobsen, S. E. W., & Allman, D. (2013) · Immunity · doi:10.1016/j.immuni.2013.01.014 · Cited by 72 · see citing works

Single-cell immune profiling reveals thymus-seeding populations, T cell commitment, and multilineage development in the human thymus

Cordes, M., Canté-Barrett, K., van den Akker, E. B., Moretti, F. A., Kiełbasa, S. M., Vloemans, S. A., García-Pérez, L., Teodósio, C., van Dongen, J. J. M., Pike‐Overzet, K., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.ade0182 · Cited by 71 · see citing works

From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells

Steinke, F. C., & Xue, H. (2014) · Immunologic Research · doi:10.1007/s12026-014-8545-9 · Cited by 69 · see citing works

Transcription factor expression dynamics of early T-lymphocyte specification and commitment

David‐Fung, E., Butler, R. R., Buzi, G., Yui, M. A., Diamond, R. A., Anderson, M. K., Rowen, L., & Rothenberg, E. V. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.021 · Cited by 68 · see citing works

Molecular mechanisms that control mouse and human TCR-αβ and TCR-γδ T cell development

Taghon, T., & Rothenberg, E. V. (2008) · Seminars in Immunopathology · doi:10.1007/s00281-008-0134-3 · Cited by 67 · see citing works

Rbpj expression in regulatory T cells is critical for restraining TH2 responses

Delacher, M., Schmidl, C., Herzig, Y., Breloer, M., Hartmann, W., Brunk, F., Kägebein, D., Träger, U., Hofer, A.-C., Bittner, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09276-w · Cited by 63 · see citing works

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

de Walle, I. V., Dolens, A., Durinck, K., Katrien De Mulder, A., Loocke, W. V., Damle, S. S., Waegemans, E., Medts, J. D., Velghe, I., Smedt, M. D., et al. (2016) · Nature Communications · doi:10.1038/ncomms11171 · Cited by 65 · see citing works

Airway inflammation in asthma

KleinJan, A. (2015) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000224 · Cited by 63 · see citing works

Forging T-Lymphocyte Identity

Rothenberg, E. V., Ungerbäck, J., & Champhekar, A. (2016) · Advances in Immunology · doi:10.1016/bs.ai.2015.09.002 · Cited by 61 · see citing works

Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate

Sakata‐Yanagimoto, M., Nakagami‐Yamaguchi, E., Saito, T., Kumano, K., Yasutomo, K., Ogawa, S., Kurokawa, M., & Chiba, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801074105 · Cited by 63 · see citing works

On becoming a T cell, a convergence of factors kick it up a Notch along the way

Thompson, P. K., & Zúñiga‐Pflücker, J. C. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.08.007 · Cited by 59 · see citing works

Notch Signaling During Human T cell Development

Taghon, T., Waegemans, E., & de Walle, I. V. (2012) · Current topics in microbiology and immunology · doi:10.1007/82_2012_230 · Cited by 58 · see citing works

GATA3 cooperates with PARP1 to regulate CCND1 transcription through modulating histone H1 incorporation

Shan, L., Li, X., Liu, L., Ding, X., Wang, Q., Zheng, Y., Duan, Y., Xuan, C., Wang, Y., Yang, F., et al. (2013) · Oncogene · doi:10.1038/onc.2013.270 · Cited by 58 · see citing works

Early T cell development and the pitfalls of potential

Schlenner, S., & Rodewald, H.-R. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.06.002 · Cited by 57 · see citing works

Developmental plasticity of lymphocytes

Cobaleda, C., & Busslinger, M. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.03.017 · Cited by 57 · see citing works

Single-cell deletion analyses show control of pro–T cell developmental speed and pathways by Tcf7, Spi1, Gata3, Bcl11a, Erg, and Bcl11b

Zhou, W., Gao, F., Romero-Wolf, M., Jo, S., & Rothenberg, E. V. (2022) · Science Immunology · doi:10.1126/sciimmunol.abm1920 · Cited by 56 · see citing works

Notch signaling is necessary for GATA3 function in the initiation of T cell development

Hozumi, K., Negishi, N., Tsuchiya, I., Abe, N., Hirano, K., Suzuki, D., Yamamoto, M. P., Engel, J. D., & Habu, S. (2008) · European Journal of Immunology · doi:10.1002/eji.200737688 · Cited by 56 · see citing works

Regulatory mechanisms of thymus and T cell development

Ma, D., Wei, Y., & Liu, F. (2011) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2011.12.013 · Cited by 55 · see citing works

Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes

Zhang, M., Dong, Y., Hu, F., Yang, D., Zhao, Q., Lv, C., Wang, Y., Xia, C., Weng, Q., Liu, X., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0046-x · Cited by 53 · see citing works

Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors

Guo, R., Hu, F., Weng, Q., Lv, C., Wu, H., Liu, L., Li, Z., Zeng, Y., Bai, Z., Zhang, M., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0251-7 · Cited by 53 · see citing works

Notch signaling in differentiation and function of dendritic cells

Cheng, P., & Gabrilovich, D. I. (2007) · Immunologic Research · doi:10.1007/s12026-007-8011-z · Cited by 53 · see citing works

Transcriptional regulators dictate innate lymphoid cell fates

Zhong, C., & Zhu, J. (2017) · Protein & Cell · doi:10.1007/s13238-017-0369-7 · Cited by 51 · see citing works

Transcriptional regulation of adaptive and innate lymphoid lineage specification

Spinner, C. A., & Lazarevic, V. (2020) · Immunological Reviews · doi:10.1111/imr.12935 · Cited by 50 · see citing works

Factors and networks that underpin early hematopoiesis

Mercer, E. M., Lin, Y. C., & Murre, C. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.08.004 · Cited by 47 · see citing works

GATA-3 Regulates the Homeostasis and Activation of CD8+ T Cells

Tai, T.-S., Pai, S., & Ho, I. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201361 · Cited by 45 · see citing works

An NK and T Cell Enhancer Lies 280 Kilobase Pairs 3′ to the Gata3 Structural Gene

Hosoya-Ohmura, S., Lin, Y.-H., Herrmann, M., Kuroha, T., Rao, A. U. K., Moriguchi, T., Lim, K.-C., Hosoya, T., & Engel, J. D. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05065-11 · Cited by 45 · see citing works

An enriched network motif family regulates multistep cell fate transitions with restricted reversibility

Ye, Y., Kang, X., Bailey, J., Li, C., & Hong, T. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006855 · Cited by 42 · see citing works

GATA‐3‐specific DNAzyme — A novel approach for stratified asthma therapy

Garn, H., & Renz, H. (2016) · European Journal of Immunology · doi:10.1002/eji.201646450 · Cited by 44 · see citing works

Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination

Rothenberg, E. V., & Scripture-Adams, D. D. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2008.07.006 · Cited by 43 · see citing works

Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cellsPreprint

Luyten, A., Zang, C., Liu, X. S., & Shivdasani, R. A. (2014) · Genes & Development · doi:10.1101/gad.240101.114 · Cited by 42 · see citing works

Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer

Oskeritzian, C. A. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.03.018 · Cited by 42 · see citing works

Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development

Romero-Wolf, M., Shin, B., Zhou, W., Koizumi, M., Rothenberg, E. V., & Hosokawa, H. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.202005093 · Cited by 42 · see citing works

Regulatory gene network circuits underlying T cell development from multipotent progenitors

Kueh, H. Y., & Rothenberg, E. V. (2011) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.162 · Cited by 41 · see citing works

The development of human mast cells. An historical reappraisal

Ribatti, D. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.03.013 · Cited by 41 · see citing works

Id1 Attenuates Notch Signaling and Impairs T-Cell Commitment by Elevating Deltex1 Expression

Wang, H.-C., Perry, S. S., & Sun, X.-H. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00119-09 · Cited by 41 · see citing works

Fbw7 Targets GATA3 through Cyclin-Dependent Kinase 2-Dependent Proteolysis and Contributes to Regulation of T-Cell Development

Kitagawa, K., Shibata, K., Matsumoto, A., Matsumoto, M., Ohhata, T., Nakayama, K. I., Niida, H., & Kitagawa, M. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01549-13 · Cited by 40 · see citing works

HEB-Deficient T-Cell Precursors Lose T-Cell Potential and Adopt an Alternative Pathway of Differentiation

Braunstein, M., & Anderson, M. K. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01034-10 · Cited by 40 · see citing works

Functional definition of a transcription factor hierarchy regulating T cell lineage commitment

García-Pérez, L., Famili, F., Cordes, M., Brugman, M. H., van Eggermond, M. C. J. A., Wu, H., Chouaref, J., León, D. S., Tiemessen, M. M., Pike‐Overzet, K., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaw7313 · Cited by 40 · see citing works

The zebrafish reveals dependence of the mast cell lineage on Notch signaling in vivo

Da'as, S. I., Coombs, A. J., Balci, T. B., Grondin, C. A., Ferrando, A. A., & Berman, J. N. (2012) · Blood · doi:10.1182/blood-2011-10-385989 · Cited by 39 · see citing works

HEB in the Spotlight: Transcriptional Regulation of T-Cell Specification, Commitment, and Developmental Plasticity

Braunstein, M., & Anderson, M. K. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/678705 · Cited by 39 · see citing works

Hematopoiesis and T‐cell specification as a model developmental system

Rothenberg, E. V., Kueh, H. Y., Yui, M. A., & Zhang, J. A. (2016) · Immunological Reviews · doi:10.1111/imr.12417 · Cited by 36 · see citing works

Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms

Shin, B., Zhou, W., Wang, J., Gao, F., & Rothenberg, E. V. (2023) · Nature Immunology · doi:10.1038/s41590-023-01585-z · Cited by 34 · see citing works

The intrathymic crossroads of T and NK cell differentiation

Wolterink, R. G. J. K., García‐Ojeda, M. E., Vosshenrich, C. A. J., Hendriks, R. W., & Santo, J. P. D. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00960.x · Cited by 34 · see citing works

Mast cell transcriptional networks

Takemoto, C. M., Lee, Y.-N., Jegga, A. G., Zablocki, D., Brandal, S., Shahlaee, A. H., Huang, S., Ye, Y., Gowrisankar, S., Huynh, J. L., et al. (2008) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2008.02.005 · Cited by 33 · see citing works

Association of CRTH2 Gene Polymorphisms with the Required Dose of Antihistamines in Patients with Chronic Urticaria

Palikhe, N. S., Kim, S., Ye, Y., Hur, G. Y., Cho, B.-Y., & Park, H. (2009) · Pharmacogenomics · doi:10.2217/14622416.10.3.375 · Cited by 32 · see citing works

Deconstructing a Complex Molecular Phenotype: Population-Level Variation in Individual Venom Proteins in Eastern Massasauga Rattlesnakes (Sistrurus c. catenatus)

Gibbs, H. L., & Chiucchi, J. E. (2011) · Journal of Molecular Evolution · doi:10.1007/s00239-011-9437-4 · Cited by 31 · see citing works

Transcriptional regulation of lymphocyte development

Dias, S., Xu, W., McGregor, S. M., & Kee, B. L. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.07.015 · Cited by 30 · see citing works

The multi-faceted role of Gata3 in developmental haematopoiesis

Zaidan, N. M., & Ottersbach, K. (2018) · Open Biology · doi:10.1098/rsob.180152 · Cited by 31 · see citing works

No DL1 Notch ligand? GATA be a mast cell

Winandy, S., & Brown, M. A. (2007) · Nature Immunology · doi:10.1038/ni0807-796 · Cited by 11 · see citing works

GATA-3 promotes T-cell specification by repressing B-cell potential in pro–T cells in mice

García‐Ojeda, M. E., Wolterink, R. G. J. K., Lemaı̂tre, F., Goff, O. R.-L., Hasan, M., Hendriks, R. W., Cumano, A., & Santo, J. P. D. (2013) · Blood · doi:10.1182/blood-2012-06-440065 · Cited by 105 · see citing works

GATA-3 seals Notch-induced T cell commitment (46.1)

García‐Ojeda, M. E., Lemaı̂tre, F., Goff, O. R.-L., Hendriks, R. W., Cumano, A., & Santo, J. P. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.supp.46.1

Analysis of signals that regulate the fate of early T cell precursors (36.53)

Al-Kuhlani, M., Ciriza, J., Peiris, T. H., Ramos, J., Bañuelos, D., & García‐Ojeda, M. E. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.184.supp.36.53

Notch signaling is necessary for GATA3 function in the initiation of T cell development

Hozumi, K., Negishi, N., Tsuchiya, I., Abe, N., Hirano, K., Suzuki, D., Yamamoto, M. P., Engel, J. D., & Habu, S. (2008) · European Journal of Immunology · doi:10.1002/eji.200737688 · Cited by 56 · see citing works