The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
High-dimensional and large-scale phenotyping of yeast mutants
Open accessAbstract
One of the most powerful techniques for attributing functions to genes in uni- and multicellular organisms is comprehensive analysis of mutant traits. In this study, systematic and quantitative analyses of mutant traits are achieved in the budding yeast Saccharomyces cerevisiae by investigating morphological phenotypes. Analysis of fluorescent microscopic images of triple-stained cells makes it possible to treat morphological variations as quantitative traits. Deletion of nearly half of the yeast genes not essential for growth affects these morphological traits. Similar morphological phenotypes are caused by deletions of functionally related genes, enabling a functional assignment of a locus to a specific cellular pathway. The high-dimensional phenotypic analysis of defined yeast mutant strains provides another step toward attributing gene function to all of the genes in the yeast genome.
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Cites
The Nature of Statistical Learning Theory
Vapnik, V. N. (1995) · doi:10.1007/978-1-4757-2440-0 · Cited by 39,138
A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
Uetz, P., Giot, L., Cagney, G., Mansfield, T. A., Judson, R. S., Knight, J. R., Lockshon, D., Narayan, V., Srinivasan, M., Pochart, P., et al. (2000) · Nature · doi:10.1038/35001009 · Cited by 4,706
Global analysis of protein localization in budding yeast
Huh, W.-K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., & O'Shea, E. K. (2003) · Nature · doi:10.1038/nature02026 · Cited by 4,248
Scholes, D. T., Banerjee, M., Bowen, B., & Curcio, M. J. (2001) · Genetics · doi:10.1093/genetics/159.4.1449 · Cited by 235
Cited by
Robustness: mechanisms and consequences
Masel, J., & Siegal, M. L. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.07.005 · Cited by 348
Genetic interactions reveal the evolutionary trajectories of duplicate genes
VanderSluis, B., Bellay, J., Musso, G., Costanzo, M., Papp, B., Vizeacoumar, F. J., Baryshnikova, A., Andrews, B., Boone, C., & Myers, C. L. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.82 · Cited by 110
Metadata
- Authors
- Ohya, Y., Sese, J., Yukawa, M., Sano, F., Nakatani, Y., Saito, T. L., Saka, A., Fukuda, T., Ishihara, S., Oka, S., Suzuki, G., Watanabe, M., Hirata, A., Ohtani, M., Sawai, H., Fraysse, N., Latgé, J.-P., François, J. M., Aebi, M., Tanaka, S., Muramatsu, S., Araki, H., Sonoike, K., Nogami, S., & Morishita, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-12-19
- Volume
- 102
- Issue
- 52
- Pages
- 19015-19020
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2133422502
- Cited by
- 307
- References
- 4
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- green
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