Cited by 110Bioinformatics and Genomic NetworksFungal and yeast genetics researchEvolution and Genetic Dynamics

Genetic interactions reveal the evolutionary trajectories of duplicate genes

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VanderSluis, Benjamin, Bellay, Jeremy, Musso, Gabriel, Costanzo, Michael, Papp, Balázs, Vizeacoumar, Franco J, Baryshnikova, Anastasia, Andrews, Brenda +2 more·2010·Molecular Systems Biology

Abstract

The characterization of functional redundancy and divergence between duplicate genes is an important step in understanding the evolution of genetic systems. Large-scale genetic network analysis in Saccharomyces cerevisiae provides a powerful perspective for addressing these questions through quantitative measurements of genetic interactions between pairs of duplicated genes, and more generally, through the study of genome-wide genetic interaction profiles associated with duplicated genes. We show that duplicate genes exhibit fewer genetic interactions than other genes because they tend to buffer one another functionally, whereas observed interactions are non-overlapping and reflect their divergent roles. We also show that duplicate gene pairs are highly imbalanced in their number of genetic interactions with other genes, a pattern that appears to result from asymmetric evolution, such that one duplicate evolves or degrades faster than the other and often becomes functionally or conditionally specialized. The differences in genetic interactions are predictive of differences in several other evolutionary and physiological properties of duplicate pairs.

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  • Duplicated genes with overlapping function often are buffered more extensively, such that more complex triple mutant analysis will be required to reveal their genetic interaction profiles.

    “One interesting case involves duplicated genes with overlapping function, which often are buffered more extensively, such that more complex triple mutant analysis will be required to reveal their genetic interaction profiles (1, 40).”

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Authors
VanderSluis, B., Bellay, J., Musso, G., Costanzo, M., Papp, B., Vizeacoumar, F. J., Baryshnikova, A., Andrews, B., Boone, C., & Myers, C. L.
Affiliations
  • University of Minnesota (US)
  • University of Toronto (CA)
  • University of Cambridge (GB)
Corresponding author
Myers, Chad L
Venue
Molecular Systems Biology
Published
2010-11-16
Volume
6
Issue
1
Pages
429-429
ISSN
1744-4292 (ISSN-L)
OpenAlex
W2148726194
Cited by
110
References
69
Citations by year
2026: 5 · 2025: 9 · 2024: 3 · 2023: 7 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 19 · 2016: 5 · 2015: 7 · 2014: 9 · 2013: 15 · 2012: 10
FWCI
4.17
Type
journal article
Language
en
Open access
Locations
  • Molecular Systems Biology (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • University of Minnesota
  • Canadian Institute for Advanced Research
  • Genome Canada
  • Ontario Genomics
  • Ontario Genomics Institute
  • Hungarian Scientific Research Fund
  • Magyar Tudományos Akadémia
  • National Institutes of Health
  • Canadian Institutes of Health Research (GSP-415-67)
  • National Human Genome Research Institute (R01HG005084)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords
duplicate genes, gene duplication, genetic interactions, functional redundancy, functional divergence, Saccharomyces cerevisiae, evolutionary trajectories
MeSH terms
Biological Evolution, Models, Genetic, Saccharomyces cerevisiae, Genetic Variation, Gene Expression, Gene Expression Regulation, Fungal, Genome, Fungal, Gene Dosage, Evolution, Molecular, Genes, Duplicate, Genome-Wide Association Study

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