The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis
Open accessAbstract
Fibrocytes are a distinct population of bloodborne cells that share markers of leukocytes as well as mesenchymal cells. We hypothesized that CCR7-positive fibrocytes migrate into the kidney in response to secondary lymphoid tissue chemokine (SLC/CCL21) and contribute to renal fibrosis. To investigate this hypothesis, renal fibrosis was induced by unilateral ureteral obstruction in mice. A considerable number of fibrocytes dual-positive for CD45 and type I collagen (ColI) or CD34 and ColI infiltrated the interstitium, reaching a peak on day 7. Most fibrocytes were positive for CCR7, and CCL21/CCR7 blockade reduced the number of infiltrating fibrocytes. CCL21 and MECA79 dual-positive vessels were also detected in the interstitium. The blockade of CCL21/CCR7 signaling by anti-CCL21 antibodies reduced renal fibrosis, which was confirmed by a decrease in fibrosis in CCR7-null mice with concomitant reduction in renal transcripts of pro α1 chain of ColI and TGF-β 1. The number of F4/80-positive macrophages decreased along with renal transcripts of monocyte chemoattractant protein 1 (MCP-1/CCL2) after the blockade of CCL21/CCR7 signaling. These findings suggest that CCR7-positive fibrocytes infiltrate the kidney via CCL21-positive vessels, thereby contributing to the pathogenesis of renal fibrosis. Thus, the CCL21/CCR7 signaling of fibrocytes may provide therapeutic targets for combating renal fibrosis.
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Evidence that fibroblasts derive from epithelium during tissue fibrosis
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Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair
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Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
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Cited by
Macrophages: versatile players in renal inflammation and fibrosis
Tang, P. M.-K., Nikolic-Paterson, D. J., & Lan, H.-Y. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0110-2 · Cited by 1,033
Galectin-3 Expression and Secretion Links Macrophages to the Promotion of Renal Fibrosis
Henderson, N. C., Mackinnon, A. C., Farnworth, S. L., Kipari, T., Haslett, C., Iredale, J. P., Liu, F.-T., Hughes, J., & Sethi, T. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070726 · Cited by 562
Kisseleva, T., & Brenner, D. A. (2008) · Experimental Biology and Medicine · doi:10.3181/0707-mr-190 · Cited by 503
Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation
Shao, D. D., Suresh, R., Vakil, V., Gomer, R. H., & Pilling, D. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1107782 · Cited by 272
Reduction of Bleomycin-Induced Pulmonary Fibrosis by Serum Amyloid P
Pilling, D., Roife, D., Wang, M., Ronkainen, S. D., Crawford, J. R., Travis, E. L., & Gomer, R. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4035 · Cited by 230
Metadata
- Authors
- Sakai, N., Wada, T., Yokoyama, H., Lipp, M., Ueha, S., Matsushima, K., & Kaneko, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-09-19
- Volume
- 103
- Issue
- 38
- Pages
- 14098-14103
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2004434046
- Cited by
- 278
- References
- 38
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Sakai, N., Wada, T., Yokoyama, H., Lipp, M., Ueha, S., Matsushima, K., & Kaneko, S. (2006). Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0511200103
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