The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
Open accessAbstract
Suppressor of cytokine signaling (Socs) 3 is a cytokine-inducible inhibitor with critical but selective cell-specific effects. We show that deficiency of Socs3 in T cells had minimal effects on differentiation of T cells to the T helper (Th) 1 or Th2 subsets; accordingly, Socs3 had no effect on IL-12-dependent signal transducer and activator of transcription (Stat) 4 phosphorylation or IL-4-dependent Stat6 phosphorylation. By contrast, Socs3 was found to be a major regulator of IL-23-mediated Stat3 phosphorylation and Th17 generation, and Stat3 directly binds to the IL-17A and IL-17F promoters. We conclude that Socs3 is an essential negative regulator of IL-23 signaling, inhibition of which constrains the generation of Th17 differentiation.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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Essential role of Stat6 in IL-4 signalling
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T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
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SOCS3 negatively regulates IL-6 signaling in vivo
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IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
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Cited by
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
STATs in cancer inflammation and immunity: a leading role for STAT3
Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383
Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
IL-17 family cytokines and the expanding diversity of effector T cell lineages
Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842
Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812
Metadata
- Authors
- Chen, Z., Laurence, A., Kanno, Y., Pacher-Zavisin, M., Zhu, B.-M., Tato, C., Yoshimura, A., Hennighausen, L., & O'Shea, J. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-05-23
- Volume
- 103
- Issue
- 21
- Pages
- 8137-8142
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2101365364
- Cited by
- 653
- References
- 14
- FWCI
- 22.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, Z., Laurence, A., Kanno, Y., Pacher-Zavisin, M., Zhu, B.-M., Tato, C., Yoshimura, A., Hennighausen, L., & O'Shea, J. J. (2006). Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0600666103
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