The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Evidence for a role of developmental genes in the origin of obesity and body fat distribution
Abstract
Obesity, especially central obesity, is a hereditable trait associated with a high risk for development of diabetes and metabolic disorders. Combined gene expression analysis of adipocyte- and preadipocyte-containing fractions from intraabdominal and subcutaneous adipose tissue of mice revealed coordinated depot-specific differences in expression of multiple genes involved in embryonic development and pattern specification. These differences were intrinsic and persisted during in vitro culture and differentiation. Similar depot-specific differences in expression of developmental genes were observed in human subcutaneous versus visceral adipose tissue. Furthermore, in humans, several genes exhibited changes in expression that correlated closely with body mass index and/or waist/hip ratio. Together, these data suggest that genetically programmed developmental differences in adipocytes and their precursors in different regions of the body play an important role in obesity, body fat distribution, and potential functional differences between internal and subcutaneous adipose tissue.
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Cites
Age, anatomic site, and the replication and differentiation of adipocyte precursors
Kirkland, J. L., Hollenberg, C. H., & Gillon, W. S. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.2.c206 · Cited by 180
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Cited by
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Wu, J., Boström, P., Sparks, L. M., Ye, L., Choi, J. H., Giang, A.-H., Khandekar, M., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,319
Adipocyte differentiation from the inside out
Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Developmental Origin of Fat: Tracking Obesity to Its Source
Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508
Self-citationForming functional fat: a growing understanding of adipocyte differentiation
Cristancho, A. G., & Lazar, M. A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3198 · Cited by 1,382
Metadata
- Authors
- Gesta, S., Blüher, M., Yamamoto, Y., Norris, A. W., Berndt, J., Kralisch, S., Boucher, J., Lewis, C., & Kahn, C. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-04-25
- Volume
- 103
- Issue
- 17
- Pages
- 6676-6681
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2140886368
- Cited by
- 617
- References
- 2
- FWCI
- 19.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gesta, S., Blüher, M., Yamamoto, Y., Norris, A. W., Berndt, J., Kralisch, S., Boucher, J., Lewis, C., & Kahn, C. R. (2006). Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0601752103
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