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Cited by 1,382Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Forming functional fat: a growing understanding of adipocyte differentiation

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Cristancho, Ana G., Lazar, Mitchell A.·2011·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm3198PMC PMC7171550
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Abstract

Adipose tissue, which is primarily composed of adipocytes, is crucial for maintaining energy and metabolic homeostasis. Adipogenesis is thought to occur in two stages: commitment of mesenchymal stem cells to a preadipocyte fate and terminal differentiation. Cell shape and extracellular matrix remodelling have recently been found to regulate preadipocyte commitment and competency by modulating WNT and RHO-family GTPase signalling cascades. Adipogenic stimuli induce terminal differentiation in committed preadipocytes through the epigenomic activation of peroxisome proliferator-activated receptor-γ (PPARγ). The coordination of PPARγ with CCAAT/enhancer-binding protein (C/EBP) transcription factors maintains adipocyte gene expression. Improving our understanding of these mechanisms may allow us to identify therapeutic targets against metabolic diseases that are rapidly becoming epidemic globally.

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  • STAT3 facilitates adipogenesis from preadipocytes through epigenetic activation of PPARγ and transcriptional upregulation of C/EBPβ.

    “STAT3 facilitates adipogenesis from preadipocytes”

    From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Cristancho and Lazar, 2011

    The ‘C/EBP activation by adipogenic stimuli’ section says that a JAK2–STAT3 cascade directly promotes C/EBPβ expression in committed preadipocytes, supporting the printed sentence. The ‘Epigenomics provides insights into early PPARγ activation’ section discusses epigenetic regulation of PPARγ but does not attribute that regulation to STAT3, so the fuller quoted mechanism is not fully supported. No page numbers are available in our copy. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Cristancho, A. G., & Lazar, M. A.
Affiliations
University of Pennsylvania (US)
Corresponding author
Lazar, Mitchell A.
ORCID
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2011-09-28
Volume
12
Issue
11
Pages
722-734
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
DOI
10.1038/nrm3198
PMC
PMC7171550
OpenAlex
W2016701686
Cited by
1,382
References
9
Citations by year
2026: 50 · 2025: 67 · 2024: 101 · 2023: 87 · 2022: 107 · 2021: 99 · 2020: 93 · 2019: 98 · 2018: 102 · 2017: 110 · 2016: 109 · 2015: 97 · 2014: 105 · 2013: 95 · 2012: 61
FWCI
7.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institutes of Health (5r01dk049780-29)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK49780, R01-DK049780)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
adipogenesis, mesenchymal stem cells, terminal differentiation, extracellular matrix remodeling, cell shape, Wnt signaling, Rho GTPase signaling, PPARγ, C/EBP transcription factors, epigenetic regulation, metabolic disorders, adipose tissue
MeSH terms
Animals, Cell Differentiation, Extracellular Matrix, Humans, Models, Biological, Signal Transduction, Transforming Growth Factor beta, Adipocytes, Cell Lineage, rho GTP-Binding Proteins, CCAAT-Enhancer-Binding Proteins, Epigenesis, Genetic, PPAR gamma, Cell Shape, Adipogenesis, Mesenchymal Stem Cells, Wnt Signaling Pathway

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