The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Host defenses against Staphylococcus aureus infection require recognition of bacterial lipoproteins
Open accessAbstract
Toll-like receptors and other immune-signaling pathways play important roles as sensors of bacterial pattern molecules, such as peptidoglycan, lipoprotein, or teichoic acid, triggering innate host immune responses that prevent infection. Immune recognition of multiple bacterial products has been viewed as a safeguard against stealth infections; however, this hypothesis has never been tested for Staphylococcus aureus, a frequent human pathogen. By generating mutations that block the diacylglycerol modification of lipoprotein precursors, we show here that S. aureus variants lacking lipoproteins escape immune recognition and cause lethal infections with disseminated abscess formation, failing to elicit an adequate host response. Thus, lipoproteins appear to play distinct, nonredundant roles in pathogen recognition and host innate defense mechanisms against S. aureus infections.
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Cites
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2
Schwandner, R., Dziarski, R., Wesche, H., Rothe, M., & Kirschning, C. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17406 · Cited by 1,704
Iron-Source Preference of Staphylococcus aureus Infections
Skaar, E. P., Humayun, M., Bae, T., DeBord, K. L., & Schneewind, O. (2004) · Science · doi:10.1126/science.1099930 · Cited by 440
Cited by
Pathogenicity and virulence of Staphylococcus aureus
Cheung, G. Y. C., Bae, J. S., & Otto, M. (2021) · Virulence · doi:10.1080/21505594.2021.1878688 · Cited by 1,380
Lipoproteins of Bacterial Pathogens
Kovacs-Simon, A., Titball, R. W., & Michell, S. L. (2011) · Infection and Immunity · doi:10.1128/iai.00682-10 · Cited by 440
Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences
Royet, J., & Dziarski, R. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1620 · Cited by 419
The Role of Macrophages in Staphylococcus aureus Infection
Pidwill, G. R., Gibson, J. F., Cole, J., Renshaw, S. A., & Foster, S. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.620339 · Cited by 341
A play in four acts: Staphylococcus aureus abscess formation
Cheng, A. G., DeDent, A. C., Schneewind, O., & Missiakas, D. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.01.007 · Cited by 310
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Metadata
- Authors
- Bubeck Wardenburg, J., Williams, W. A., & Missiakas, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-09-12
- Volume
- 103
- Issue
- 37
- Pages
- 13831-13836
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1963492926
- Cited by
- 262
- References
- 3
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- green
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