Cited by 442Redox biology and oxidative stressNF-κB Signaling PathwaysGenomics, phytochemicals, and oxidative stress

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Dynamic redox control of NF-κB through glutaredoxin-regulated S-glutathionylation of inhibitory κB kinase β

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Reynaert, Niki L., van der Vliet, Albert, Guala, Amy S., McGovern, Toby, Hristova, Milena, Pantano, Cristen, Heintz, Nicholas H., Heim, John, Ho, Ye-Shih, Matthews, Dwight E., Wouters, Emiel F. M., Janssen-Heininger, Yvonne M. W.·2006·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0603290103PMC PMC1559757

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Abstract

The transcription factor NF-κB, a central regulator of immunity, is subject to regulation by redox changes. We now report that cysteine-179 of the inhibitory κB kinase (IKK) β-subunit of the IKK signalosome is a central target for oxidative inactivation by means of S-glutathionylation. S-glutathionylation of IKK-β Cys-179 is reversed by glutaredoxin (GRX), which restores kinase activity. Conversely, GRX1 knockdown sensitizes cells to oxidative inactivation of IKK-β and dampens TNF-α-induced IKK and NF-κB activation. Primary tracheal epithelial cells from Glrx1 -deficient mice display reduced NF-κB DNA binding, RelA nuclear translocation, and MIP-2 (macrophage inflammatory protein 2) and keratinocyte-derived chemokine production in response to LPS. Collectively, these findings demonstrate the physiological relevance of the S-glutathionylation–GRX redox module in controlling the magnitude of activation of the NF-κB pathway.

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Authors: Reynaert, N. L., van der Vliet, A., Guala, A. S., McGovern, T., Hristova, M., Pantano, C., Heintz, N. H., Heim, J., Ho, Y.-S., Matthews, D. E., Wouters, E. F. M., & Janssen-Heininger, Y. M. W.
Affiliations: Maastricht University (NL)
Departments of *Pathology and
University of Vermont (US)
Wayne State University (US)
ORCID: Reynaert, Niki L.
Guala, Amy S.
Hristova, Milena
Ho, Ye-Shih
Matthews, Dwight E.
Wouters, Emiel F. M.
Janssen-Heininger, Yvonne M. W.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2006-08-29
Volume: 103
Issue: 35
Pages: 13086-13091
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0603290103
PMC: PMC1559757
OpenAlex: W2166902551
Cited by: 442
References: 37
Citations by year: 2026: 19 · 2025: 12 · 2024: 19 · 2023: 19 · 2022: 18 · 2021: 20 · 2020: 23 · 2019: 23 · 2018: 13 · 2017: 25 · 2016: 18 · 2015: 24 · 2014: 22 · 2013: 28 · 2012: 29
FWCI: 9.51
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Funders: National Institutes of Health (P20 RL15557)
U.S. Public Health Service (P20 RL-15557)
National Heart, Lung, and Blood Institute (R01 HL60014, P01 HL074295, R01HL074295, R01HL060812, R01HL060014, HL 60812)
National Center for Research Resources (P20RR015557)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: NF-κB, S-glutathionylation, glutaredoxin, redox regulation, oxidative inactivation, TNF signaling, tracheal epithelial cells, lipopolysaccharide response, chemokine production, p65 nuclear translocation
MeSH terms: Animals, Cells, Cultured, Cysteine, Glutathione, Hydrogen Peroxide, Lipopolysaccharides, Mice, Inbred C57BL, Oxidation-Reduction, Oxidoreductases, Respiratory System, Sulfenic Acids, Keratinocytes, Monokines, NF-kappa B, Chemokines, Protein Subunits, Mice, I-kappa B Kinase, Chemokine CXCL2, Glutaredoxins

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Dynamic redox control of NF-κB through glutaredoxin-regulated S-glutathionylation of inhibitory κB kinase β

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