Glatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1

Butovsky, Oleg; Koronyo-Hamaoui, Maya; Kunis, Gilad; Ophir, Eran; Landa, Gennady; Cohen, Hagit; Schwartz, Michal

doi:10.1073/pnas.0604681103

Glatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1

Alzheimer’s disease (AD) is characterized by plaque formation, neuronal loss, and cognitive decline. The functions of the local and systemic immune response in this disease are still controversial. Using AD double-transgenic (APP/PS1) mice, we show that a T cell-based vaccination with glatiramer …