The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects
Open accessAbstract
Although neurotrophins have been postulated to have antidepressant properties, their effect on anxiety is not clear. We find that transgenic overexpression of the neurotrophin BDNF has an unexpected facilitatory effect on anxiety-like behavior, concomitant with increased spinogenesis in the basolateral amygdala. Moreover, anxiogenesis and amygdalar spinogenesis are also triggered by chronic stress in control mice but are occluded by BDNF overexpression, thereby suggesting a role for BDNF signaling in stress-induced plasticity in the amygdala. BDNF overexpression also causes antidepressant effects, because transgenic mice exhibit improved performance on the Porsolt forced-swim test and an absence of chronic stress-induced hippocampal atrophy. Thus, structural changes in the amygdala and hippocampus, caused by genetic manipulation of the same molecule BDNF, give rise to contrasting effects on anxiety and depressive symptoms, both of which are major behavioral correlates of stress disorders.
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Cites
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Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228
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Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex
McEwen, B. S., Nasca, C., & Gray, J. D. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.171 · Cited by 1,574
Mechanisms of stress in the brain
McEwen, B. S., Bowles, N. P., Gray, J. D., Hill, M. N., Hunter, R. G., Karatsoreos, I. N., & Nasca, C. (2015) · Nature Neuroscience · doi:10.1038/nn.4086 · Cited by 1,386
Metadata
- Authors
- Govindarajan, A., Rao, B. S. S., Nair, D., Trinh, M., Mawjee, N., Tonegawa, S., & Chattarji, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-08-29
- Volume
- 103
- Issue
- 35
- Pages
- 13208-13213
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2000793737
- Cited by
- 333
- References
- 14
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Govindarajan, A., Rao, B. S. S., Nair, D., Trinh, M., Mawjee, N., Tonegawa, S., & Chattarji, S. (2006). Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0605180103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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