L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis
Open accessAbstract
L-selectin mediates homing of lymphocytes to lymph nodes (LN). Transgenic mice that express rat insulin promoter regulated simian virus 40 Tag (RIP-Tag) develop large, local cancers that metastasize to liver but not LN. To test whether this lack of LN metastases reflects their absence from the circulation, transgenic mice were produced that express Tag (T), L-selectin (L), and Escherichia coli LacZ (Z), in pancreatic β cells. LTZ mice developed insulinomas that specifically had LN metastases; metastasis was blocked by an anti L-selectin mAb. LacZ + tumor cells from these LN homed to secondary LN upon transfer. These results suggest that the highly vascularized islet carcinomas are shedding tumor cells into the bloodstream, which is a necessary but insufficient condition for metastasis to occur; L-selectin can facilitate homing of such tumor cells to LN, resulting in metastasis.
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Expression of L-selectin on tumour cells can foster metastasis to lymph nodes.
“In addition, expression of L-selectin on tumour cells can foster metastasis to lymph nodes56.”
From Inflammation and cancer (2002) · cites this paper as [56]
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- Authors
- Qian, F., Hanahan, D., & Weissman, I. L.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-03-13
- Volume
- 98
- Issue
- 7
- Pages
- 3976-3981
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC31164
- OpenAlex
- W1993748733
- Cited by
- 80
- References
- 43
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r35ca042551-13)
- National Cancer Institute (CA 42551)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- L-selectin, lymph node metastasis, lymphocyte homing, insulinoma, pancreatic beta cells, carcinogenesis, transgenic mouse model
- MeSH terms
- Animals, Antigens, Surface, Disease Models, Animal, Immunohistochemistry, Lymphatic Metastasis, Lymphatic System, Membrane Proteins, Mice, Transgenic, Carcinogenicity Tests, L-Selectin, Mice
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