Cited by 80Cell Adhesion Molecules ResearchChemokine receptors and signalingCancer Cells and Metastasis

L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis

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Qian, Fawn, Hanahan, Douglas, Weissman, Irving L.·2001·Proceedings of the National Academy of Sciences

Abstract

L-selectin mediates homing of lymphocytes to lymph nodes (LN). Transgenic mice that express rat insulin promoter regulated simian virus 40 Tag (RIP-Tag) develop large, local cancers that metastasize to liver but not LN. To test whether this lack of LN metastases reflects their absence from the circulation, transgenic mice were produced that express Tag (T), L-selectin (L), and Escherichia coli LacZ (Z), in pancreatic β cells. LTZ mice developed insulinomas that specifically had LN metastases; metastasis was blocked by an anti L-selectin mAb. LacZ + tumor cells from these LN homed to secondary LN upon transfer. These results suggest that the highly vascularized islet carcinomas are shedding tumor cells into the bloodstream, which is a necessary but insufficient condition for metastasis to occur; L-selectin can facilitate homing of such tumor cells to LN, resulting in metastasis.

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Registry

Crossref · 10.1073/pnas.061633698

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43 of 43 references verified0 citation errors · 0 not checkable

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  • Expression of L-selectin on tumour cells can foster metastasis to lymph nodes.

    “In addition, expression of L-selectin on tumour cells can foster metastasis to lymph nodes56.”

    From Inflammation and cancer (2002) · cites this paper as [56]

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Authors
Qian, F., Hanahan, D., & Weissman, I. L.
Affiliations
University of California, San Francisco (US)
Venue
Proceedings of the National Academy of Sciences
Published
2001-03-13
Volume
98
Issue
7
Pages
3976-3981
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1993748733
Cited by
80
References
43
Citations by year
2026: 1 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 2
FWCI
2.09
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r35ca042551-13)
  • National Cancer Institute (CA 42551)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
L-selectin, lymph node metastasis, lymphocyte homing, insulinoma, pancreatic beta cells, carcinogenesis, transgenic mouse model
MeSH terms
Animals, Antigens, Surface, Disease Models, Animal, Immunohistochemistry, Lymphatic Metastasis, Lymphatic System, Membrane Proteins, Mice, Transgenic, Carcinogenicity Tests, L-Selectin, Mice

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