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Virus-assisted loading of polymer nanocontainer
Open accessAbstract
We present a DNA-containing polymeric nanocontainer using the self-assembled superstructure of amphiphilic block copolymers in aqueous solutions. To demonstrate that DNA translocation is possible across a completely synthetic block copolymer membrane, we have used a phage transfection strategy as a DNA-transfer model system. For this purpose the bacterial channel forming protein LamB was reconstituted in ABA-triblock copolymer vesicles. The outer membrane protein LamB is a specific transporter for maltodextrins but also serves as a receptor for λ phage to trigger the ejection of λ phage DNA. We demonstrate that the functionality of the LamB protein is fully preserved despite the artificial surrounding. This leads to a type of polymeric vehicle for DNA that could be useful for gene therapy.
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Cited by
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Rodríguez-Hernández, J., & Lecommandoux, S. (2005) · Journal of the American Chemical Society · doi:10.1021/ja043920g · Cited by 678
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Luxenhofer, R., Han, Y., Schulz, A., Tong, J., He, Z., Kabanov, A. V., & Jordan, R. (2012) · Macromolecular Rapid Communications · doi:10.1002/marc.201200354 · Cited by 470
Self-assembling materials for therapeutic delivery
Branco, M. C., & Schneider, J. P. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2008.09.018 · Cited by 462
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Evilevitch, A., Lavelle, L., Knobler, C. M., Raspaud, E., & Gelbart, W. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1233721100 · Cited by 334
Metadata
- Authors
- Graff, A., Sauer, M., Van Gelder, P., & Meier, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-03-26
- Volume
- 99
- Issue
- 8
- Pages
- 5064-5068
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977665107
- Cited by
- 247
- References
- 0
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Graff, A., Sauer, M., Van Gelder, P., & Meier, W. (2002). Virus-assisted loading of polymer nanocontainer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.062654499
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