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Enterobactin: an archetype for microbial iron transport.
Open accessAbstract
Bacteria have aggressive acquisition processes for iron, an essential nutrient. Siderophores are small iron chelators that facilitate cellular iron transport. The siderophore enterobactin is a triscatechol derivative of a cyclic triserine lactone. Studies of the chemistry, regulation, synthesis, recognition, and transport of enterobactin make it perhaps the best understood of the siderophore-mediated iron uptake systems, displaying a lot of function packed into this small molecule. However, recent surprises include the isolation of corynebactin, a closely related trithreonine triscatechol derivative lactone first found in Gram-positive bacteria, and the crystal structure of a ferric enterobactin complex of a protein identified as an antibacterial component of the human innate immune system.
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“Given the low Fe bioavailability in an aqueous environment (free Fe3+ concentration below 10−9 M at pH 7) and the further strict active withholding of Fe within mammalian hosts (free serum Fe concentration of approximately 10−24 M) [9]”
From Host Iron Withholding Demands Siderophore Utilization for Candida glabrata to Survive Macrophage Killing (2011) · cites this paper as [9]
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Facile Siderophore Assembly Enables Bacterial Delivery of Nucleic Acid Therapeutics
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Medley, A. W., & Bender, T. A. (2026) · European Journal of Inorganic Chemistry · doi:10.1002/ejic.202500488 · Cited by 1
Metadata
- Authors
- Raymond, K. N., Dertz, E. A., & Kim, S. S.
- Affiliations
- University of California, Berkeley (US)
- ORCID
- Raymond, Kenneth N.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2003-03-24
- Volume
- 100
- Issue
- 7
- Pages
- 3584-3588
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC152965
- OpenAlex
- W1972422447
- Cited by
- 933
- References
- 83
- Citations by year
- 2026: 42 · 2025: 57 · 2024: 55 · 2023: 47 · 2022: 67 · 2021: 46 · 2020: 49 · 2019: 59 · 2018: 50 · 2017: 47 · 2016: 38 · 2015: 38 · 2014: 47 · 2013: 27 · 2012: 45
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI011744, AI-11744)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- enterobactin, siderophores, bacterial iron acquisition, iron transport, siderophore biosynthesis, innate immunity, Gram-positive bacteria
- MeSH terms
- Bacteria, Binding Sites, Carrier Proteins, Enterobactin, Iron, Models, Molecular, Protein Conformation, Protein Structure, Secondary
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