Cited by 939Bacterial Genetics and BiotechnologyMicrobial Natural Products and BiosynthesisIron Metabolism and Disorders

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Enterobactin: an archetype for microbial iron transport.

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Raymond, Kenneth N., Dertz, Emily A., Kim, Sanggoo S.·2003·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0630018100PMC PMC152965

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Abstract

Bacteria have aggressive acquisition processes for iron, an essential nutrient. Siderophores are small iron chelators that facilitate cellular iron transport. The siderophore enterobactin is a triscatechol derivative of a cyclic triserine lactone. Studies of the chemistry, regulation, synthesis, recognition, and transport of enterobactin make it perhaps the best understood of the siderophore-mediated iron uptake systems, displaying a lot of function packed into this small molecule. However, recent surprises include the isolation of corynebactin, a closely related trithreonine triscatechol derivative lactone first found in Gram-positive bacteria, and the crystal structure of a ferric enterobactin complex of a protein identified as an antibacterial component of the human innate immune system.

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Authors: Raymond, K. N., Dertz, E. A., & Kim, S. S.
Affiliations: University of California, Berkeley (US)
ORCID: Raymond, Kenneth N.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2003-03-24
Volume: 100
Issue: 7
Pages: 3584-3588
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0630018100
PMC: PMC152965
OpenAlex: W1972422447
Cited by: 933
References: 83
Citations by year: 2026: 42 · 2025: 57 · 2024: 55 · 2023: 47 · 2022: 67 · 2021: 46 · 2020: 49 · 2019: 59 · 2018: 50 · 2017: 47 · 2016: 38 · 2015: 38 · 2014: 47 · 2013: 27 · 2012: 45
FWCI: 1.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01AI011744, AI-11744)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: enterobactin, siderophores, bacterial iron acquisition, iron transport, siderophore biosynthesis, innate immunity, Gram-positive bacteria
MeSH terms: Bacteria, Binding Sites, Carrier Proteins, Enterobactin, Iron, Models, Molecular, Protein Conformation, Protein Structure, Secondary

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Enterobactin: an archetype for microbial iron transport.

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