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Cited by 939Bacterial Genetics and BiotechnologyMicrobial Natural Products and BiosynthesisIron Metabolism and Disorders

The DOI matches its Crossref record; 80 of the 83 references it cites were found in a registry or an index.

Enterobactin: an archetype for microbial iron transport.

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Raymond, Kenneth N., Dertz, Emily A., Kim, Sanggoo S.·2003·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0630018100PMC PMC152965
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Abstract

Bacteria have aggressive acquisition processes for iron, an essential nutrient. Siderophores are small iron chelators that facilitate cellular iron transport. The siderophore enterobactin is a triscatechol derivative of a cyclic triserine lactone. Studies of the chemistry, regulation, synthesis, recognition, and transport of enterobactin make it perhaps the best understood of the siderophore-mediated iron uptake systems, displaying a lot of function packed into this small molecule. However, recent surprises include the isolation of corynebactin, a closely related trithreonine triscatechol derivative lactone first found in Gram-positive bacteria, and the crystal structure of a ferric enterobactin complex of a protein identified as an antibacterial component of the human innate immune system.

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Crossref · 10.1073/pnas.0630018100

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Research works printed but not linked: 5

  1. J J Bullen, L C Leigh, H J Rogers Immunology 15, 581–588 (1968).
  2. 10.1016/0378-1097(90)90522-R · DOI
  3. J J Bullen, H J Rogers, J E Lewin Immunology 20, 391–406 (1971).
  4. A Trousseau Lect Clin Med 5, 95–117 (1872).
  5. V Braun, K Hantke CRC Handbook of Microbial Iron Chelators, ed G Winkelmann (CRC, Boca Raton, FL), pp. 107–138 (1991).

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Metadata

Authors
Raymond, K. N., Dertz, E. A., & Kim, S. S.
Affiliations
University of California, Berkeley (US)
ORCID
Raymond, Kenneth N.
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2003-03-24
Volume
100
Issue
7
Pages
3584-3588
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0630018100
PMC
PMC152965
OpenAlex
W1972422447
Cited by
933
References
83
Citations by year
2026: 42 · 2025: 57 · 2024: 55 · 2023: 47 · 2022: 67 · 2021: 46 · 2020: 49 · 2019: 59 · 2018: 50 · 2017: 47 · 2016: 38 · 2015: 38 · 2014: 47 · 2013: 27 · 2012: 45
FWCI
1.91
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (R01AI011744, AI-11744)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
enterobactin, siderophores, bacterial iron acquisition, iron transport, siderophore biosynthesis, innate immunity, Gram-positive bacteria
MeSH terms
Bacteria, Binding Sites, Carrier Proteins, Enterobactin, Iron, Models, Molecular, Protein Conformation, Protein Structure, Secondary

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