The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Meeting of the minds: Metalloneurochemistry
Open accessAbstract
Metalloneurochemistry is the study of metal ion function in the brain and nervous system at the molecular level. Research in this area is exemplified through discussion of several forefront areas where significant progress has been made in recent years. The structure and function of ion channels have been elucidated through high-resolution x-ray structural work on the bacterial K + ion channel. Selection of potassium over sodium ions is achieved by taking advantage of key principles of coordination chemistry. The role of calcium ions in neuronal signal transduction is effected by several Ca 2+ -binding protein such as calmodulin, calcineurin, and synaptotagmin. Structural changes in response to calcium ion concentrations allow these proteins to function in memory formation and other neurochemical roles. Metallochaperones help to achieve metal ion homeostasis and thus prevent neurological diseases because of metal ion imbalance. Much detailed chemical information about these systems has become available recently. Zinc is another important metal ion in neuroscience. Its concentration in brain is in part controlled by metallothionein, and zinc is released in the hippocampus at glutamatergic synapses. New fluorescent sensors have become available to help track such zinc release.
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Cites
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The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia
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Cited by
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Jiang, P., & Guo, Z. (2004) · Coordination Chemistry Reviews · doi:10.1016/j.cct.2003.10.013 · Cited by 989
Small-Molecule Fluorescent Sensors for Investigating Zinc Metalloneurochemistry
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Self-citationMetal-associated amyloid-β species in Alzheimer's disease
Pithadia, A. S., & Lim, M. H. (2012) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2012.01.016 · Cited by 259
High-Efficiency in Vitro and in Vivo Detection of Zn2+ by Dye-Assembled Upconversion Nanoparticles
Peng, J., Xu, W., Teoh, C. L., Han, S., Kim, B., Samanta, A., Er, J. C., Wang, L., Yuan, L., Liu, X., et al. (2015) · Journal of the American Chemical Society · doi:10.1021/ja5115248 · Cited by 257
Metadata
- Authors
- Burdette, S. C., & Lippard, S. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-03-24
- Volume
- 100
- Issue
- 7
- Pages
- 3605-3610
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1967123623
- Cited by
- 269
- References
- 88
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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