Metal-associated amyloid-β species in Alzheimer's disease

Pithadia, Amit S; Lim, Mi Hee

doi:10.1016/j.cbpa.2012.01.016

Cited by 259Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAluminum toxicity and tolerance in plants and animals

Metal-associated amyloid-β species in Alzheimer's disease

Pithadia, Amit S, Lim, Mi Hee·2012·Current Opinion in Chemical Biology

DOI 10.1016/j.cbpa.2012.01.016

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Abstract

Highly concentrated metals such as Cu, Zn, and Fe are found in amyloid-β (Aβ) plaques within the brain of Alzheimer's disease (AD). In vitro and in vivo studies have suggested that metal binding to Aβ could facilitate Aβ aggregation and generate reactive oxygen species (ROS), which could contribute to the neuropathogenesis of AD. The connection between metal-Aβ interaction/reactivity and AD development, however, has not been clearly revealed owing to the complexity of the disease. In this review, metal-Aβ interaction/reactivity and its relation to neurotoxicity are briefly discussed. Additionally, our review illustrates the recent progress of small molecules, capable of targeting metal-Aβ species and modulating their interaction/reactivity, which could offer a promising approach to interrogate their role in AD.

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Recent efforts to control abnormal Aβ-metal interactions have focused on small molecules, bifunctional chelators (BFCs), that have binding affinity for both metal ions and Aβ aggregates.
“Recent efforts to control abnormal Aβ–metal interactions have focused on small molecules, bifunctional chelators (BFCs), that have binding affinity for both metal ions and Aβ aggregates.20,25,27−30”
From Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity (2014) · cites this paper as [29]

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Self-citation

Authors: Pithadia, A. S., & Lim, M. H.
Affiliations: University of Michigan (US)
Corresponding author: Lim, Mi Hee
ORCID: Lim, Mi Hee
Venue: Current Opinion in Chemical Biology
Publisher: Elsevier BV
Published: 2012-04
Volume: 16
Issue: 1-2
Pages: 67-73
ISSN: 1367-5931 (ISSN-L)
DOI: 10.1016/j.cbpa.2012.01.016
OpenAlex: W1984223653
Cited by: 259
References: 48
Citations by year: 2026: 3 · 2025: 12 · 2024: 10 · 2023: 14 · 2022: 11 · 2021: 17 · 2020: 21 · 2019: 28 · 2018: 30 · 2017: 25 · 2016: 16 · 2015: 18 · 2014: 26 · 2013: 20 · 2012: 8
FWCI: 2.48
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Chemical Biology (publishedVersion)
PubMed (publishedVersion)
Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
Keywords: Alzheimer's disease, amyloid-beta, metal ion binding, copper, zinc, iron, amyloid plaques, amyloid-beta aggregation, reactive oxygen species, neurotoxicity, metal chelators
MeSH terms: Alzheimer Disease, Amyloid, Humans, Metals, Reactive Oxygen Species

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Metal-associated amyloid-β species in Alzheimer's disease

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