The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency
Open accessAbstract
Embryonic stem cells (ESCs) represent an important research tool and a potential resource for regenerative medicine. Generally, ESCs are cocultured with a supportive feeder cell layer of murine embryonic fibroblasts, which maintain the ESCs' capacity for self-renewal and block spontaneous differentiation. These cumbersome conditions, as well as the risk of xenobiotic contamination of human ESCs grown on murine embryonic fibroblasts, make it a priority to develop chemically defined methods that can be safely used for the expansion of ESCs. Using a high-throughput, cell-based assay, we identified the small molecule IQ-1 that allows for the Wnt/β-catenin-driven long-term expansion of mouse ESCs and prevents spontaneous differentiation. We demonstrate that IQ-1, by targeting the PR72/130 subunit of the serine/threonine phosphatase PP2A, prevents β-catenin from switching coactivator usage from CBP to p300. The increase in β-catenin/CBP-mediated transcription at the expense of β-catenin/p300-mediated transcription is critical for the maintenance of murine stem cell pluripotency.
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Citations
Cites
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
Wnt and calcium signaling: β-Catenin-independent pathways
Kohn, A. D., & Moon, R. T. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.06.022 · Cited by 730
Cited by
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
Nusse, R., & Clevers, H. (2017) · Cell · doi:10.1016/j.cell.2017.05.016 · Cited by 4,342
The many faces and functions of β‐catenin
Valenta, T., Hausmann, G., & Basler, K. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.150 · Cited by 1,598
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
Liu, Y., Dentin, R., Chen, D., Hedrick, S., Ravnskjaer, K., Schenk, S., Milne, J., Meyers, D. J., Cole, P., III, J. Y., et al. (2008) · Nature · doi:10.1038/nature07349 · Cited by 484
Mitotic and mitogenic Wnt signalling
Niehrs, C., & Acebron, S. P. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.124 · Cited by 305
Sampath, P., Pritchard, D. K., Pabon, L., Reinecke, H., Schwartz, S. M., Morris, D. R., & Murry, C. E. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.03.013 · Cited by 277
Metadata
- Authors
- Miyabayashi, T., Teo, J.-L., Yamamoto, M., McMillan, M., Nguyen, C., & Kahn, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-03-27
- Volume
- 104
- Issue
- 13
- Pages
- 5668-5673
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2038833190
- Cited by
- 310
- References
- 2
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Miyabayashi, T., Teo, J.-L., Yamamoto, M., McMillan, M., Nguyen, C., & Kahn, M. (2007). Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0701331104
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