Microtubule curvatures under perpendicular electric forces reveal a low persistence length
Open accessAbstract
The mechanics of microtubules, cylindrical protein filaments that constitute the cytoskeleton, have been well characterized on long length scales. Here, we investigate the persistence length of short (approximately 0.1 microm) ends of microtubules by measuring the trajectories of kinesin-propelled microtubules under perpendicular electric forces. We relate the measured trajectory curvatures to the biased thermal fluctuations of the leading microtubule end, and upon including all electrohydrodynamic forces, we find that the persistence length of the microtubule ends is only 0.08 +/- 0.02 mm. This is significantly shorter than the well established value of approximately 4-8 mm that is measured for long microtubules. Our data are in good agreement with recent theoretical predictions that microtubules mechanically behave as a loose assembly of independent protofilaments on these short length scales.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Alignment of microtubules in low intensity DC electric fields has been observed in kinesin-propelled microtubule assays.
“Alignment of microtubules in low intensity DC electric fields has been observed in kinesin-propelled microtubule assays [36].”
From Tumor Treating Fields (TTFields) Hinder Cancer Cell Motility through Regulation of Microtubule and Actin Dynamics (2020) · cites this paper as [36]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Flexural rigidity of microtubules and actin filaments measured from thermal fluctuations in shape
Gittes, F., Mickey, B., Nettleton, J., & Howard, J. (1993) · Journal of Cell Biology · doi:10.1083/jcb.120.4.923 · Cited by 1,788 · see citing works
Surface-Charge-Governed Ion Transport in Nanofluidic Channels
Stein, D., Kruithof, M., & Dekker, C. (2004) · Physical Review Letters · doi:10.1103/physrevlett.93.035901 · Cited by 1,169 · see citing works
Self-citationMotor Proteins at Work for Nanotechnology
van den Heuvel, M. G. L., & Dekker, C. (2007) · Science · doi:10.1126/science.1139570 · Cited by 562 · see citing works
Self-citationKinesin Takes One 8-nm Step for Each ATP That It Hydrolyzes
Coy, D. L., Wagenbach, M., & Howard, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.6.3667 · Cited by 390 · see citing works
Pampaloni, F., Lattanzi, G., Jonáš, A., Surrey, T., Frey, E., & Florin, E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603931103 · Cited by 359 · see citing works
Kis, A., Kasas, S., Babić, B., Kulik, A., Benoît, W., Briggs, G. A. D., Schönenberger, C., Catsicas, S., & Laszlo Forro, C. (2002) · Physical Review Letters · doi:10.1103/physrevlett.89.248101 · Cited by 352 · see citing works
Flexural rigidity of microtubules measured with the use of optical tweezers
Felgner, H., Frank, R. W., & Schliwa, M. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.2.509 · Cited by 297 · see citing works
Analysis of microtubule rigidity using hydrodynamic flow and thermal fluctuations.
Venier, P., Maggs, A. C., Carlier, M., & Pantaloni, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36840-0 · Cited by 255 · see citing works
Powering Nanodevices with Biomolecular Motors
Hess, H., Bachand, G. D., & Viola Vogel, B. (2004) · Chemistry - A European Journal · doi:10.1002/chem.200305712 · Cited by 252 · see citing works
Deformation and Collapse of Microtubules on the Nanometer Scale
de Pablo, P. J., Schaap, I. A. T., MacKintosh, F. C., & Schmidt, C. F. (2003) · Physical Review Letters · doi:10.1103/physrevlett.91.098101 · Cited by 250 · see citing works
Molecular Sorting by Electrical Steering of Microtubules in Kinesin-Coated Channels
van den Heuvel, M. G. L., de Graaff, M. P., & Dekker, C. (2006) · Science · doi:10.1126/science.1124258 · Cited by 244 · see citing works
Self-citationSuppressing Brownian motion of individual biomolecules in solution
Cohen, A. E., & Moerner, W. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509976103 · Cited by 242 · see citing works
A Bending Mode Analysis for Growing Microtubules: Evidence for a Velocity-Dependent Rigidity
Janson, M. E., & Dogterom, M. (2004) · Biophysical Journal · doi:10.1529/biophysj.103.038877 · Cited by 170 · see citing works
Acting on actin: the electric motility assay
Riveline, D., Ott, A., Jülicher, F., Winkelmann, D. A., Cardoso, O., Lacapère, J.-J., Magnúsdóttir, S., Viovy, J., Talini, L., & Prost, J. (1998) · European Biophysics Journal · doi:10.1007/s002490050147 · Cited by 151 · see citing works
Analysis of the migration behaviour of single microtubules in electric fields
Stracke, R., Böhm, K. J., Wollweber, L., Tuszynski, J. A., & Unger, E. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00251-6 · Cited by 147 · see citing works
Kerssemakers, J. W. J., Howard, J., Hess, H., & Diez, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510400103 · Cited by 137 · see citing works
Statistical Mechanics of Semiflexible Bundles of Wormlike Polymer Chains
Heussinger, C., Bathe, M., & Frey, E. (2007) · Physical Review Letters · doi:10.1103/physrevlett.99.048101 · Cited by 126 · see citing works
Microscale Transport and Sorting by Kinesin Molecular Motors
Jia, L., Moorjani, S. G., Jackson, T. N., & Hancock, W. O. (2004) · Biomedical Microdevices · doi:10.1023/b:bmmd.0000013368.89455.8d · Cited by 122 · see citing works
Clemmens, J., Hess, H., Howard, J., & Viola Vogel, B. (2002) · Langmuir · doi:10.1021/la026155x · Cited by 117 · see citing works
Kinesin swivels to permit microtubule movement in any direction.
Hunt, A. J., & Howard, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11653 · Cited by 105 · see citing works
"Gliding Assays" for Motor Proteins: A Theoretical Analysis
Duke, T. A. J., Holy, T. E., & Leibler, S. (1995) · Physical Review Letters · doi:10.1103/physrevlett.74.330 · Cited by 93 · see citing works
Dispersion in Active Transport by Kinesin-Powered Molecular Shuttles
Nitta, T., & Hess, H. (2005) · Nano Letters · doi:10.1021/nl050586t · Cited by 93 · see citing works
Effect of temperature on kinesin‐driven microtubule gliding and kinesin ATPase activity
Böhm, K. J., Stracke, R., Baum, M., Zieren, M., & Unger, E. (2000) · FEBS Letters · doi:10.1016/s0014-5793(99)01757-3 · Cited by 84 · see citing works
Active Alignment of Microtubules with Electric Fields
Kim, T., Kao, M., Hasselbrink, E. F., & Meyhöfer, E. (2006) · Nano Letters · doi:10.1021/nl061474k · Cited by 80 · see citing works
Electrophoresis of individual microtubules in microchannels
van den Heuvel, M. G. L., de Graaff, M. P., Lemay, S. G., & Dekker, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608316104 · Cited by 62 · see citing works
Self-citationElectrical Docking of Microtubules for Kinesin-Driven Motility in Nanostructures
van den Heuvel, M. G. L., Butcher, C. T., Lemay, S. G., Diez, S., & Dekker, C. (2005) · Nano Letters · doi:10.1021/nl048291n · Cited by 53 · see citing works
Self-citationTheory for the Hydrodynamic and Electrophoretic Stretch of Tethered B-DNA
Stigter, D., & Bustamante, C. (1998) · Biophysical Journal · doi:10.1016/s0006-3495(98)74039-1 · Cited by 52 · see citing works
Persistence Length Measurements from Stochastic Single-Microtubule Trajectories
van den Heuvel, M. G. L., Bolhuis, S., & Dekker, C. (2007) · Nano Letters · doi:10.1021/nl071696y · Cited by 50 · see citing works
Self-citationDepinning of semiflexible polymers
Benetatos, P., & Frey, E. (2003) · Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics · doi:10.1103/physreve.67.051108 · Cited by 46 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Bathe M, Heussinger C, Claessens M, Bausch A, Frey E (2006) arxiv.org:q-bio/0607040. · arXiv
Cited by
Sorted by citations
Ashkenasy, G., Hermans, T. M., Otto, S., & Taylor, A. F. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00117g · Cited by 595 · see citing works
Hawkins, T. L., Mirigian, M., Yasar, M. S., & Ross, J. L. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.09.005 · Cited by 271 · see citing works
Biomolecular motors at the intersection of nanotechnology and polymer science
Agarwal, A., & Hess, H. (2009) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.10.007 · Cited by 147 · see citing works
Voloshin, T., Schneiderman, R. S., Volodin, A., Shamir, R. R., Kaynan, N., Zeevi, E., Koren, L., Klein-Goldberg, A., Paz, R., Giladi, M., et al. (2020) · Cancers · doi:10.3390/cancers12103016 · Cited by 94 · see citing works
New Insights into the Mechanisms of Cytomotive Actin and Tubulin Filaments
Aylett, C. H. S., Löwe, J., & Amos, L. (2011) · International review of cytology · doi:10.1016/b978-0-12-386033-0.00001-3 · Cited by 69 · see citing works
Buckling of Microtubules on a 2D Elastic Medium
Kabir, A. M. R., Inoue, D., Afrin, T., Mayama, H., Sada, K., & Kakugo, A. (2015) · Scientific Reports · doi:10.1038/srep17222 · Cited by 58 · see citing works
Statics and dynamics of the wormlike bundle model
Heussinger, C., Schüller, F., & Frey, E. (2010) · Physical Review E · doi:10.1103/physreve.81.021904 · Cited by 56 · see citing works
A computational framework for cortical microtubule dynamics in realistically shaped plant cells
Chakrabortty, B., Blilou, I., Scheres, B., & Mulder, B. M. (2018) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005959 · Cited by 54 · see citing works
Microtubules soften due to cross-sectional flattening
Memet, E., Hilitski, F., MORRIS, M. A., Schwenger, W. J., Dogic, Z., & Mahadevan, L. (2018) · eLife · doi:10.7554/elife.34695 · Cited by 54 · see citing works
Takatsuki, H., Bengtsson, E., & Månsson, A. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.01.012 · Cited by 52 · see citing works
Bending Flexibility of Actin Filaments during Motor-Induced Sliding
Vikhorev, P. G., Vikhoreva, N. N., & Månsson, A. (2008) · Biophysical Journal · doi:10.1529/biophysj.108.140335 · Cited by 50 · see citing works
Molecular structural mechanics model for the mechanical properties of microtubules
Zhang, J., & Wang, C. (2014) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-014-0564-x · Cited by 39 · see citing works
Control of molecular shuttles by designing electrical and mechanical properties of microtubules
Isozaki, N., Shintaku, H., Kotera, H., Hawkins, T. L., Ross, J. L., & Yokokawa, R. (2017) · Science Robotics · doi:10.1126/scirobotics.aan4882 · Cited by 39 · see citing works
Tubulin Bistability and Polymorphic Dynamics of Microtubules
Mohrbach, H., Johner, A., & Kulić, I. M. (2010) · Physical Review Letters · doi:10.1103/physrevlett.105.268102 · Cited by 32 · see citing works
Yang, Q., Karpikov, A., Toomre, D. K., & Duncan, J. S. (2011) · IEEE Transactions on Image Processing · doi:10.1109/tip.2011.2114359 · Cited by 32 · see citing works
Spectral Analysis Methods for the Robust Measurement of the Flexural Rigidity of Biopolymers
Valdman, D., Atzberger, P. J., Yu, D., Kuei, S., & Valentine, M. T. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.01.045 · Cited by 32 · see citing works
Patterns of molecular motors that guide and sort filaments
Rupp, B., & Nédélec, F. (2012) · Lab on a Chip · doi:10.1039/c2lc40250e · Cited by 30 · see citing works
Xue, C., Shtylla, B., & Brown, A. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004406 · Cited by 30 · see citing works
New insights into F-pilus structure, dynamics, and function
Silverman, P. M., & Clarke, M. B. (2009) · Integrative Biology · doi:10.1039/b917761b · Cited by 30 · see citing works
Control of microtubule trajectory within an electric field by altering surface charge density
Isozaki, N., Suguru, A. N. D. O., NAKAHARA, T., Shintaku, H., Kotera, H., Meyhöfer, E., & Yokokawa, R. (2015) · Scientific Reports · doi:10.1038/srep07669 · Cited by 30 · see citing works
Kaneko, T., Furuta, K., Oiwa, K., Shintaku, H., Kotera, H., & Yokokawa, R. (2020) · Science Advances · doi:10.1126/sciadv.aax7413 · Cited by 29 · see citing works
Xiang, P., Zhang, L., & Liew, K. M. (2016) · Composite Structures · doi:10.1016/j.compstruct.2016.03.063 · Cited by 28 · see citing works
Confined-microtubule assembly shapes three-dimensional cell wall structures in xylem vessels
Sasaki, T., Saito, K., Inoue, D., Serk, H., Sugiyama, Y., Pesquet, E., Shimamoto, Y., & Oda, Y. (2023) · Nature Communications · doi:10.1038/s41467-023-42487-w · Cited by 26 · see citing works
In silico design and testing of guiding tracks for molecular shuttles powered by kinesin motors
Nitta, T., Tanahashi, A., & Hirano, M. (2010) · Lab on a Chip · doi:10.1039/b926210e · Cited by 25 · see citing works
Measurement of the persistence length of cytoskeletal filaments using curvature distributions
Wisanpitayakorn, P., Mickolajczyk, K. J., Hancock, W. O., Vidali, L., & Tüzel, E. (2022) · Biophysical Journal · doi:10.1016/j.bpj.2022.04.020 · Cited by 24 · see citing works
Single Centrosome Manipulation Reveals Its Electric Charge and Associated Dynamic Structure
Hormeño, S., Ibarra, B., Chichón, F. J., Habermann, K., Lange, B. M. H., Valpuesta, J., Carrascosa, J. L., & Arias‐Gonzalez, J. R. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.06.004 · Cited by 24 · see citing works
Wu, Z., Nogales, E., & Xing, J. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.05.003 · Cited by 23 · see citing works
Cooperative lattice dynamics and anomalous fluctuations of microtubules
Mohrbach, H., Johner, A., & Kulić, I. M. (2011) · European Biophysics Journal · doi:10.1007/s00249-011-0778-0 · Cited by 23 · see citing works
Tug-of-war of microtubule filaments at the boundary of a kinesin- and dynein-patterned surface
Ikuta, J., Kamisetty, N. K., Shintaku, H., Kotera, H., Kon, T., & Yokokawa, R. (2014) · Scientific Reports · doi:10.1038/srep05281 · Cited by 20 · see citing works
Optimization of Isopolar Microtubule Arrays
Agayan, R. R., Tucker, R., Nitta, T., Ruhnow, F., Walter, W. J., Diez, S., & Hess, H. (2013) · Langmuir · doi:10.1021/la303792v · Cited by 18 · see citing works
Kumar, K. R. S., Amrutha, A. S., & Tamaoki, N. (2016) · Lab on a Chip · doi:10.1039/c6lc01098a · Cited by 16 · see citing works
Modeling material transport regulation and traffic jam in neurons using PDE-constrained optimization
Li, A., & Zhang, Y. J. (2022) · Scientific Reports · doi:10.1038/s41598-022-07861-6 · Cited by 16 · see citing works
Measuring the number and spacing of molecular motors propelling a gliding microtubule
Fallesen, T. L., Macosko, J. C., & Holzwarth, G. (2011) · Physical Review E · doi:10.1103/physreve.83.011918 · Cited by 15 · see citing works
Single Filament Behavior of Microtubules in the Presence of Added Divalent Counterions
Bouxsein, N. F., & Bachand, G. D. (2014) · Biomacromolecules · doi:10.1021/bm500988r · Cited by 14 · see citing works
Elastic Anisotropy Scenario for Cooperative Binding of Kinesin-Coated Beads on Microtubules
Sekimoto, K., & Prost, J. (2016) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.6b01627 · Cited by 13 · see citing works
Kinesin motor density and dynamics in gliding microtubule motility
VanDelinder, V., Imam, Z. I., & Bachand, G. D. (2019) · Scientific Reports · doi:10.1038/s41598-019-43749-8 · Cited by 13 · see citing works
Modeling intracellular transport and traffic jam in 3D neurons using PDE-constrained optimization
Li, A., & Zhang, Y. J. (2022) · Journal of Mechanics · doi:10.1093/jom/ufac007 · Cited by 13 · see citing works
Biophysical ordering transitions underlie genome 3D re-organization during cricket spermiogenesis
Orsi, G. A., Tortora, M. M. C., Horard, B., Baas, D., Kleman, J.-P., Bucevičius, J., Lukinavičius, G., Jost, D., & Loppin, B. (2023) · Nature Communications · doi:10.1038/s41467-023-39908-1 · Cited by 12 · see citing works
Effect of Nucleotide State on the Protofilament Conformation of Tubulin Octamers
Manandhar, A., Kang, M., Chakraborty, K., & Loverde, S. M. (2018) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.8b02193 · Cited by 11 · see citing works
Actin Architecture Steers Microtubules in Active Cytoskeletal Composite
Kučera, O., Gaillard, J., Guérin, C., Utzschneider, C., Théry, M., & Blanchoin, L. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c03117 · Cited by 9 · see citing works
Properties of Microtubules with Isotropic and Anisotropic Mechanics
Sim, H., & Sept, D. (2013) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-013-0302-y · Cited by 9 · see citing works
DRY & WET: meniscus splitting from a mixture of polysaccharides and water
Okeyoshi, K. (2020) · Polymer Journal · doi:10.1038/s41428-020-0369-y · Cited by 9 · see citing works
Dual-wavelength stopped-flow analysis of the lateral and longitudinal assembly kinetics of vimentin
Schween, L., Mücke, N., Portet, S., Goldmann, W. H., Herrmann, H. O., & Fabry, B. (2022) · Biophysical Journal · doi:10.1016/j.bpj.2022.09.008 · Cited by 8 · see citing works
Analytical and Numerical Methods for Capturing the Thermal Fluctuations of Semiflexible Polymers
Poelert, S. L., & ZADPOOR, A. A. (2012) · Macromolecular Theory and Simulations · doi:10.1002/mats.201100110 · Cited by 8 · see citing works
A Fluorescent GTP Analog as a Specific, High-Precision Label of Microtubules
Anderson, E. K., & Martin, D. S. (2011) · BioTechniques · doi:10.2144/000113703 · Cited by 8 · see citing works
Transport of microtubules according to the number and spacing of kinesin motors on gold nano-pillars
Kaneko, T., Suguru, A. N. D. O., Furuta, K., Oiwa, K., Shintaku, H., Kotera, H., & Yokokawa, R. (2019) · Nanoscale · doi:10.1039/c9nr01324e · Cited by 8 · see citing works
Measurement of the Persistence Length of Cytoskeletal Filaments using Curvature DistributionsPreprint
Wisanpitayakorn, P., Mickolajczyk, K. J., Hancock, W. O., Vidali, L., & Tüzel, E. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/252551 · Cited by 8 · see citing works
Building on-chip cytoskeletal circuits via branched microtubule networks
Zaferani, M., Song, R., Petry, S., & Stone, H. A. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315992121 · Cited by 6 · see citing works
Molecular recognition mechanisms directing the self-assembly of biological structures
CIFERRI, A. (2020) · Soft Matter · doi:10.1039/d0sm01301c · Cited by 6 · see citing works
Electro-detachment of kinesin motor domain from microtubule in silico
Průša, J., & Cifra, M. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.01.018 · Cited by 6 · see citing works
Maxian, O., & Peskin, C. S. (2020) · SIAM Journal on Scientific Computing · doi:10.1137/19m1280879 · Cited by 6 · see citing works
Analysis of flexural rigidity of actin filaments propelled by surface adsorbed myosin motors
Bengtsson, E., Persson, M., & Månsson, A. (2013) · Cytoskeleton · doi:10.1002/cm.21138 · Cited by 5 · see citing works
A nonequilibrium power balance relation for analyzing dissipative filament dynamics
Ziebert, F., Mohrbach, H., & Kulić, I. M. (2015) · The European Physical Journal E · doi:10.1140/epje/i2015-15129-9 · Cited by 4 · see citing works
Recent Mathematical Models of Axonal Transport
Xue, C., & Jameson, G. (2017) · Springer eBooks · doi:10.1007/978-3-319-62627-7_12 · Cited by 5 · see citing works
Zhou, H., Jung, W., Farhana, T. I., Fujimoto, K., Kim, T., & Yokokawa, R. (2022) · ACS Nano · doi:10.1021/acsnano.2c05593 · Cited by 5 · see citing works
Amiri, A., Dietz, C., Rapp, A. W., Cardoso, M. C., & Stark, R. W. (2023) · Nanoscale · doi:10.1039/d3nr02226a · Cited by 4 · see citing works
Swimming at Low Reynolds Number: From Sheets to the African Trypanosome
Babu, S. B., Schmeltzer, C., & Stark, H. (2012) · Notes on numerical fluid mechanics and multidisciplinary design · doi:10.1007/978-3-642-28302-4_2 · Cited by 4 · see citing works
Zhou, H., Isozaki, N., Fujimoto, K., & Yokokawa, R. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00960-y · Cited by 4 · see citing works
Linking path and filament persistence lengths of microtubules gliding over kinesin
Sweet, M., Kang’iri, S. M., & Nitta, T. (2022) · Scientific Reports · doi:10.1038/s41598-022-06941-x · Cited by 4 · see citing works
Transport of Ions, DNA Polymers, and Microtubules in the Nanofluidic Regime
Stein, D., van den Heuvel, M. G. L., & Dekker, C. (2016) · Royal Society of Chemistry eBooks · doi:10.1039/9781849735230-00001 · Cited by 4 · see citing works
Self-citationProtein design of two-component tubular assemblies similar to cytoskeletons
Noji, M., Sugita, Y., Yamazaki, Y., Miyazaki, M., & Suzuki, Y. (2025) · Nature Communications · doi:10.1038/s41467-025-62076-3 · Cited by 3 · see citing works
Sen, A., Chowdhury, D., & Kunwar, A. (2024) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.12.005 · Cited by 3 · see citing works
Measuring Microtubule Persistence Length Using a Microtubule Gliding Assay
Martin, D. S. (2013) · Methods in cell biology · doi:10.1016/b978-0-12-407757-7.00002-5 · Cited by 3 · see citing works
Flexural rigidity measurements of biopolymers using gliding assays.
Martin, D. S., Yu, L., & Hoozen, B. L. V. (2012) · Journal of Visualized Experiments · doi:10.3791/50117 · Cited by 2 · see citing works
Motility Resilience of Molecular Shuttles Against Defective Motors
Kang'iri, S. M., & Nitta, T. (2022) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2022.3170562 · Cited by 2 · see citing works
Mennona, N. J., Владимировна, С. А., Echchgadda, I., & Losert, W. (2023) · Physical review. E · doi:10.1103/physreve.108.034411 · Cited by 2 · see citing works
Miyazako, H., Kawamura, R., & Hoshino, T. (2022) · Biomicrofluidics · doi:10.1063/5.0124921 · Cited by 2 · see citing works
Modeling the lamellipodium of motile cells
Zimmermann, J. (2014) · edoc Publication server (Humboldt University of Berlin) · doi:10.18452/16871 · Cited by 2 · see citing works
Structure and dynamics of a four-protofilament microtubule from Heimdallarchaeales α/β-tubulin
Tran, L. T., Ali, S., Matsumoto, T., Yamazaki, Y., Narita, A., Miyazaki, M., & Robinson, R. C. (2026) · Science Advances · doi:10.1126/sciadv.aeh4305 · Cited by 1 · see citing works
Stability of Mitotic Spindle Using Computational Mechanics
Iakovliev, A., Dasmahapatra, S., & Bhaskar, A. (2019) · International Conference on Bioscience, Biochemistry and Bioinformatics (ICBBB) · doi:10.1145/3314367.3314373 · Cited by 1 · see citing works
Local direction change of surface gliding microtubules
Li, F., Pan, J., & Choi, J. H. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.26933 · Cited by 1 · see citing works
FINITE ELEMENT MODELING OF THE THERMAL FLUCTUATIONS OF A SINGLE ANISOTROPIC POLYMER
Poelert, S. L., Weinans, H., & ZADPOOR, A. A. (2013) · Journal of Mechanics in Medicine and Biology · doi:10.1142/s0219519413500565 · Cited by 1 · see citing works
Nishi, K., Raja, S. O., Pham, A., Freeman, R., Roll‐Mecak, A., MacKintosh, F. C., & Schmidt, C. F. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.26.564252 · Cited by 1 · see citing works
Magnetic steering at the nanoscale
Stickar, P. G. (2012) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-007339629
Optical velocity control of microtubules driven by kinesin motors
NAKAHARA, T., Shintaku, H., Kotera, H., & Yokokawa, R. (2014) · IEEE International Conference on Nanotechnology (IEEE-NANO) · doi:10.1109/nano.2014.6968019
Microtubule sortiing within a given electric field by designing flexural rigidity
Isozaki, N., Shintaku, H., Kotera, H., Meyhöfer, E., & Yokokawa, R. (2015) · IEEE International Conference on Micro Electro Mechanical Systems (MEMS) · doi:10.1109/memsys.2015.7050932
NAKAHARA, T., Isozaki, N., Suguru, A. N. D. O., Kamisetty, N. K., Shintaku, H., Kotera, H., & Yokokawa, R. (2014) · IEEJ Transactions on Sensors and Micromachines · doi:10.1541/ieejsmas.134.64
The influence of molecular charges on microtubule curvatures in an electrical field
Isozaki, N., NAKAHARA, T., Suguru, A. N. D. O., Kamisetty, N. K., Shintaku, H., Kotera, H., Meyhöfer, E., & Yokokawa, R. (2013) · International Conference on Solid-State Sensors, Actuators and Microsystems · doi:10.1109/transducers.2013.6627221
Thermal Fluctuations of Anisotropic Semiflexible PolymersPreprint
Poelert, S. L., Weinans, H., & ZADPOOR, A. A. (2011) · arXiv (Cornell University) · doi:10.48550/arxiv.1110.5613
Understanding molecular and cellular processes using statistical physics
Wu, Z. (2011) · VTechWorks (Virginia Tech)
MICROTUBULE GLIDING AT THE BOUNDARY OF KINESIN AND DYNEIN PATTERNED SURFACE
Ikuta, J., Kamisetty, N. K., Shintaku, H., Kotera, H., & Yokokawa, R. (2013)
Microtubule dynamics is required for rapid coiling of haptonemata in haptophyte algaePreprint
Nomura, M., Atsuji, K., Hirose, K., Shiba, K., Nakayama, T., Ishida, K., & Inaba, K. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/322453
Cooperative Lattice Dynamics and Anomalous Fluctuations of MicrotubulesPreprint
Mohrbach, H., Johner, A., & Kulić, I. M. (2011) · arXiv (Cornell University) · doi:10.48550/arxiv.1108.4800
Design of Mechanical and Electrical Properties for Multidirectional Control of Microtubules
Zhou, H., Kaneko, T., Isozaki, N., & Yokokawa, R. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-1983-4_7
Zhou, H., Isozaki, N., Fujimoto, K., & Yokokawa, R. (2021) · Figshare · doi:10.6084/m9.figshare.15020555
Small electrical field effects on biological polymers
Abazari, P., Shariatpanahi, S. P., & Goliaei, B. (2026) · Protein Science · doi:10.1002/pro.70701
Giv, A., Arani, A. G., & Haghparast, E. (2026) · Proceedings of the Institution of Mechanical Engineers Part C Journal of Mechanical Engineering Science · doi:10.1177/09544062261469004
- Authors
- Van den Heuvel, M. G. L., de Graaff, M. P., & Dekker, C.
- Affiliations
- Kavli Institute of Nanoscience, Section Molecular Biophysics, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands
- Delft University of Technology (NL)
- ORCID
- Dekker, C.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-06-10
- Volume
- 105
- Issue
- 23
- Pages
- 7941-7946
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2786941
- OpenAlex
- W2000946608
- Cited by
- 88
- References
- 29
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 11 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 7
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Electrostatics and Colloid Interactions
- Keywords
- microtubules, persistence length, microtubule ends, kinesin, electric force, electrohydrodynamic force, thermal fluctuations, microtubule curvature, cytoskeleton mechanics, protofilaments, microtubule mechanics
- MeSH terms
- Animals, Biomechanical Phenomena, Cattle, Drosophila melanogaster, Electricity, Microtubules
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review