The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Mechanism of inhibition of bovine F 1 -ATPase by resveratrol and related polyphenols
Open accessAbstract
The structures of F 1 -ATPase from bovine heart mitochondria inhibited with the dietary phytopolyphenol, resveratrol, and with the related polyphenols quercetin and piceatannol have been determined at 2.3-, 2.4- and 2.7-Å resolution, respectively. The inhibitors bind to a common site in the inside surface of an annulus made from loops in the three α- and three β-subunits beneath the “crown” of β-strands in their N-terminal domains. This region of F 1 -ATPase forms a bearing to allow the rotation of the tip of the γ-subunit inside the annulus during catalysis. The binding site is a hydrophobic pocket between the C-terminal tip of the γ-subunit and the β TP subunit, and the inhibitors are bound via H-bonds mostly to their hydroxyl moieties mediated by bound water molecules and by hydrophobic interactions. There are no equivalent sites between the γ-subunit and either the β DP or the β E subunit. The inhibitors probably prevent both the synthetic and hydrolytic activities of the enzyme by blocking both senses of rotation of the γ-subunit. The beneficial effects of dietary resveratrol may derive in part by preventing mitochondrial ATP synthesis in tumor cells, thereby inducing apoptosis.
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Metadata
- Authors
- Gledhill, J. R., Montgomery, M. G., Leslie, A. G. W., & Walker, J. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-08-21
- Volume
- 104
- Issue
- 34
- Pages
- 13632-13637
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2037998901
- Cited by
- 379
- References
- 77
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Gledhill, J. R., Montgomery, M. G., Leslie, A. G. W., & Walker, J. E. (2007). Mechanism of inhibition of bovine F 1 -ATPase by resveratrol and related polyphenols. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0706290104
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