The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens
Open accessAbstract
Fungi in the genus Malassezia are ubiquitous skin residents of humans and other warm-blooded animals. Malassezia are involved in disorders including dandruff and seborrheic dermatitis, which together affect >50% of humans. Despite the importance of Malassezia in common skin diseases, remarkably little is known at the molecular level. We describe the genome, secretory proteome, and expression of selected genes of Malassezia globosa . Further, we report a comparative survey of the genome and secretory proteome of Malassezia restricta , a close relative implicated in similar skin disorders. Adaptation to the skin environment and associated pathogenicity may be due to unique metabolic limitations and capabilities. For example, the lipid dependence of M. globosa can be explained by the apparent absence of a fatty acid synthase gene. The inability to synthesize fatty acids may be complemented by the presence of multiple secreted lipases to aid in harvesting host lipids. In addition, an abundance of genes encoding secreted hydrolases (e.g., lipases, phospholipases, aspartyl proteases, and acid sphingomyelinases) was found in the M. globosa genome. In contrast, the phylogenetically closely related plant pathogen Ustilago maydis encodes a different arsenal of extracellular hydrolases with more copies of glycosyl hydrolase genes. M. globosa shares a similar arsenal of extracellular hydrolases with the phylogenetically distant human pathogen, Candida albicans , which occupies a similar niche, indicating the importance of host-specific adaptation. The M. globosa genome sequence also revealed the presence of mating-type genes, providing an indication that Malassezia may be capable of sex.
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Cites
Improved Prediction of Signal Peptides: SignalP 3.0
Dyrløv Bendtsen, J., Nielsen, H., von Heijne, G., & Brunak, S. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.05.028 · Cited by 6,350
Eddy, S. R. (1998) · Bioinformatics · doi:10.1093/bioinformatics/14.9.755 · Cited by 5,515
Automated generation of heuristics for biological sequence comparison
Slater, G. S. C., & Birney, E. (2005) · BMC Bioinformatics · doi:10.1186/1471-2105-6-31 · Cited by 2,933
Birney, E., Clamp, M., & Durbin, R. (2004) · Genome Research · doi:10.1101/gr.1865504 · Cited by 2,542
Virulence factors of Candida albicans
Calderone, R. A., & Fonzi, W. A. (2001) · Trends in Microbiology · doi:10.1016/s0966-842x(01)02094-7 · Cited by 1,331
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
Kämper, J., Kahmann, R., Bölker, M., Ma, L.-J., Brefort, T., Saville, B. J., Banuett, F., Kronstad, J. W., Gold, S. E., Müller, O., et al. (2006) · Nature · doi:10.1038/nature05248 · Cited by 1,208
Self-citationCandida albicans Secreted Aspartyl Proteinases in Virulence and Pathogenesis
Naglik, J. R., Challacombe, S. J., & Hube, B. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.3.400-428.2003 · Cited by 1,179
Topley and Wilson's Microbiology and Microbial infections
Collier, L., Balows, A., & Sussman, M. (1998) · Edward Arnold eBooks · Cited by 788
The Ashbya gossypii Genome as a Tool for Mapping the Ancient Saccharomyces cerevisiae Genome
Dietrich, F. S., Voegeli, S., Brachat, S., Lerch, A., Gates, K., Steiner, S., Mohr, C., Pöhlmann, R., Luedi, P., Choi, S., et al. (2004) · Science · doi:10.1126/science.1095781 · Cited by 633
Skin diseases associated with Malassezia species
Gupta, A. K., Batra, R., Bluhm, R., Boekhout, T., & Dawson, T. L. (2004) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2003.12.034 · Cited by 518
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Cited by
Riley, R., Salamov, A. A., Brown, D. W., Nagy, L. G., Floudas, D., Held, B. W., Levasseur, A., Lombard, V., Morin, E., Otillar, R., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400592111 · Cited by 745
The Malassezia Genus in Skin and Systemic Diseases
Gaitanis, G., Magiatis, P., Hantschke, M., Bassukas, I. D., & Velegraki, A. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00021-11 · Cited by 642
Structure and function of the human skin microbiome
Schommer, N. N., & Gallo, R. L. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2013.10.001 · Cited by 532
Lundell, T. K., Mäkelä, M. R., & Hildén, K. (2010) · Journal of Basic Microbiology · doi:10.1002/jobm.200900338 · Cited by 477
Improved prediction of fungal effector proteins from secretomes with EffectorP 2.0
Sperschneider, J., Dodds, P. N., Gardiner, D. M., Singh, K. B., & Taylor, J. M. (2018) · Molecular Plant Pathology · doi:10.1111/mpp.12682 · Cited by 403
Metadata
- Authors
- Xu, J., Saunders, C. W., Hu, P., Grant, R. A., Boekhout, T., Kuramae, E. E., Kronstad, J. W., DeAngelis, Y. M., Reeder, N. L., Johnstone, K. R., Leland, M., Fieno, A. M., Begley, W. M., Sun, Y., Lacey, M. P., Chaudhary, T., Keough, T., Chu, L., Sears, R., Yuan, B., & Dawson, T. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-11-20
- Volume
- 104
- Issue
- 47
- Pages
- 18730-18735
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2157380302
- Cited by
- 431
- References
- 38
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Xu, J., Saunders, C. W., Hu, P., Grant, R. A., Boekhout, T., Kuramae, E. E., Kronstad, J. W., DeAngelis, Y. M., Reeder, N. L., Johnstone, K. R., Leland, M., Fieno, A. M., Begley, W. M., Sun, Y., Lacey, M. P., Chaudhary, T., Keough, T., Chu, L., Sears, R., . . . Dawson, T. L. (2007). Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0706756104
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