Cited by 229Hematopoietic Stem Cell TransplantationGenomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development

Open access
Pimanda, John E., Ottersbach, Katrin, Knezevic, Kathy, Kinston, Sarah, Chan, Wan Y. I., Wilson, Nicola K., Landry, Josette-Renée, Wood, Andrew D., Kolb-Kokocinski, Anja, Green, Anthony R., Tannahill, David, Lacaud, Georges, Kouskoff, Valerie, Göttgens, Berthold·2007·Proceedings of the National Academy of Sciences

Abstract

Conservation of the vertebrate body plan has been attributed to the evolutionary stability of gene-regulatory networks (GRNs). We describe a regulatory circuit made up of Gata2, Fli1, and Scl/Tal1 and their enhancers, Gata2-3 , Fli1 +12, and Scl +19, that operates during specification of hematopoiesis in the mouse embryo. We show that the Fli1 +12 enhancer, like the Gata2-3 and Scl +19 enhancers, targets hematopoietic stem cells (HSCs) and relies on a combination of Ets, Gata, and E-Box motifs. We show that the Gata2-3 enhancer also uses a similar cluster of motifs and that Gata2, Fli1, and Scl are expressed in embryonic day-11.5 dorsal aorta where HSCs originate and in fetal liver where they multiply. The three HSC enhancers in these tissues and in ES cell-derived hemangioblast equivalents are bound by each of these transcription factors (TFs) and form a fully connected triad that constitutes a previously undescribed example of both this network motif in mammalian development and a GRN kernel operating during the specification of a mammalian stem cell.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.0707045104

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 46 references

Research works printed but not linked: 1

  1. M Varterasian, S Lipkowitz, I Karsch-Mizrachi, B Paterson, I Kirsch Cell Growth Differ 4, 885–889 (1993).

Cited by

Sorted by citations

Items 101–200 of 229

Metadata

Authors
Pimanda, J. E., Ottersbach, K., Knezevic, K., Kinston, S., Chan, W. Y. I., Wilson, N. K., Landry, J.-R., Wood, A. D., Kolb-Kokocinski, A., Green, A. R., Tannahill, D., Lacaud, G., Kouskoff, V., & Göttgens, B.
Affiliations
  • University of Cambridge (GB)
  • The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, United Kingdom; and
  • Wellcome Sanger Institute (GB)
  • Cancer Research UK Manchester Institute (GB)
  • Paterson Institute for Cancer Research, Manchester M20 4BX, United Kingdom
Venue
Proceedings of the National Academy of Sciences
Published
2007-11-06
Volume
104
Issue
45
Pages
17692-17697
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1996351707
Cited by
228
References
46
Citations by year
2026: 5 · 2025: 4 · 2024: 3 · 2023: 11 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 19 · 2015: 16 · 2014: 17 · 2013: 22 · 2012: 18
FWCI
10.65
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
Funders
  • Wellcome Trust
  • Kay Kendall Leukaemia Fund
  • University of Oxford
  • Directorate for Biological Sciences
  • Medical Research Council
  • Biotechnology and Biological Sciences Research Council
  • National Health and Medical Research Council
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
GATA2, FLI1, SCL/TAL1, gene regulatory networks, hematopoietic stem cells, enhancers, transcription factor binding motifs, E-box motifs, dorsal aorta, fetal liver, hemangioblasts, embryonic stem cells, hematopoietic specification, network motifs
MeSH terms
T-Cell Acute Lymphocytic Leukemia Protein 1, Animals, Binding Sites, Blood Vessels, Embryo, Mammalian, Enhancer Elements, Genetic, Gene Expression Regulation, Hematopoiesis, Hematopoietic Stem Cells, Proto-Oncogene Proteins, GATA2 Transcription Factor, Mice, Proto-Oncogene Protein c-fli-1, Basic Helix-Loop-Helix Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review