Göttgens, Berthold

PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells

Wolf, F. A., Hamey, F. K., Plass, M., Solana, J., Dahlin, J. S., Göttgens, B., Rajewsky, N., Simon, L., & Theis, F. J. (2019) · Genome Biology

Single-cell and spatial transcriptomicsTopological and Geometric Data Analysis

Cited by 1,698

A single-cell molecular map of mouse gastrulation and early organogenesis

Pijuan-Sala, B., Griffiths, J. A., Guibentif, C., Hiscock, T. W., Jawaid, W., Calero-Nieto, F. J., Mulas, C., Ibarra-Soria, X., Tyser, R. C. V., Ho, D. L. L., et al. (2019) · Nature

Single-cell and spatial transcriptomicsDevelopmental Biology and Gene Regulation

Cited by 1,033

A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation

Nestorowa, S., Hamey, F. K., Pijuan Sala, B., Diamanti, E., Shepherd, M., Laurenti, E., Wilson, N. K., Kent, D. G., & Göttgens, B. (2016) · Blood

Single-cell and spatial transcriptomicsHematopoietic Stem Cell Transplantation

Cited by 768

Single-cell multi-omics analysis of the immune response in COVID-19

Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID-19 BioResource Collaboration, Stephenson, E., Reynolds, G., Botting, R. A., Calero-Nieto, F. J., Morgan, M. D., Tuong, Z. K., Bach, K., Sungnak, W., Worlock, K. B., et al. (2021) · Nature Medicine

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 742

Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators

Wilson, N. K., Foster, S. D., Wang, X., Knezevic, K., Schütte, J., Kaimakis, P., Chilarska, P. M., Kinston, S., Ouwehand, W. H., Dzierzak, E., et al. (2010) · Cell stem cell

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 728

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions

Pietras, E. M., Reynaud, D., Kang, Y.-A., Carlin, D., Calero-Nieto, F. J., Leavitt, A. D., Stuart, J. M., Göttgens, B., & Passegué, E. (2015) · Cell stem cell

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 723

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal

Sun, D., Luo, M., Jeong, M., Rodriguez, B., Xia, Z., Hannah, R., Wang, H., Le, T., Faull, K. F., Chen, R., et al. (2014) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 686

Decoding human fetal liver haematopoiesis

Popescu, D.-M., Botting, R. A., Stephenson, E., Green, K., Webb, S., Jardine, L., Calderbank, E. F., Polanski, K., Goh, I., Efremova, M., et al. (2019) · Nature

Hematopoietic Stem Cell TransplantationSingle-cell and spatial transcriptomics

Cited by 606

Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes

Bruce, A. W., Donaldson, I. J., Wood, I. C., Yerbury, S. A., Sadowski, M. I., Chapman, M., Göttgens, B., & Buckley, N. J. (2004) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsNuclear Receptors and Signaling

Cited by 485

Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations

Wilson, N. K., Kent, D. G., Buettner, F., Shehata, M., Macaulay, I. C., Calero-Nieto, F. J., Sánchez Castillo, M., Oedekoven, C. A., Diamanti, E., Schulte, R., et al. (2015) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationSingle-cell and spatial transcriptomics

Cited by 466

Decoding the regulatory network of early blood development from single-cell gene expression measurements

Moignard, V., Woodhouse, S., Haghverdi, L., Lilly, A. J., Tanaka, Y., Wilkinson, A. C., Buettner, F., Macaulay, I. C., Jawaid, W., Diamanti, E., et al. (2015) · Nature Biotechnology

Gene Regulatory Network AnalysisSingle-cell and spatial transcriptomics

Cited by 380

Local and systemic responses to SARS-CoV-2 infection in children and adults

Yoshida, M., Worlock, K. B., Huang, N., Lindeboom, R. G. H., Butler, C. R., Kumasaka, N., Dominguez Conde, C., Mamanova, L., Bolt, L., Richardson, L., et al. (2022) · Nature

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 365

Large conserved domains of low DNA methylation maintained by Dnmt3a

Jeong, M., Sun, D., Luo, M., Huang, Y., Challen, G. A., Rodriguez, B., Zhang, X., Chavez, L., Wang, H., Hannah, R., et al. (2014) · Nature Genetics

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 324

The Epidermis Comprises Autonomous Compartments Maintained by Distinct Stem Cell Populations

Page, M. E., Lombard, P., Ng, F., Göttgens, B., & Jensen, K. B. (2013) · Cell Stem Cell

Hair Growth and DisordersSkin and Cellular Biology Research

Cited by 320

Resolving early mesoderm diversification through single-cell expression profiling

Scialdone, A., Tanaka, Y., Jawaid, W., Moignard, V., Wilson, N. K., Macaulay, I. C., Marioni, J. C., & Göttgens, B. (2016) · Nature

Developmental Biology and Gene RegulationPluripotent Stem Cells Research

Cited by 293

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice

Dahlin, J. S., Hamey, F. K., Pijuan-Sala, B., Shepherd, M., Lau, W. W. Y., Nestorowa, S., Weinreb, C., Wolock, S., Hannah, R., Diamanti, E., et al. (2018) · Blood

Single-cell and spatial transcriptomicsHematopoietic Stem Cell Transplantation

Cited by 233

Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development

Pimanda, J. E., Ottersbach, K., Knezevic, K., Kinston, S., Chan, W. Y. I., Wilson, N. K., Landry, J.-R., Wood, A. D., Kolb-Kokocinski, A., Green, A. R., et al. (2007) · Proceedings of the National Academy of Sciences

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 228

Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors

Göttgens, B., Nastos, A., Kinston, S., Piltz, S., Delabesse, E. C. M., Stanley, M., Sanchez, M., Ciau‐Uitz, A., Patient, R., & Green, A. R. (2002) · The EMBO Journal

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 212

Potential Autoregulation of Transcription Factor PU.1 by an Upstream Regulatory Element

Okuno, Y., Huang, G., Rosenbauer, F., Evans, E. K., Radomska, H. S., Iwasaki, H., Akashi, K., Moreau-Gachelin, F., Li, Y., Zhang, P., et al. (2005) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 174

Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells

Staber, P. B., Zhang, P., Ye, M., Welner, R. S., Nombela-Arrieta, C., Bach, C., Kerenyi, M., Bartholdy, B. A., Zhang, H., Alberich-Jordà, M., et al. (2013) · Molecular Cell

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 158

Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes

Beck, D., Thoms, J. A. I., Perera, D., Schütte, J., Unnikrishnan, A., Knezevic, K., Kinston, S. J., Wilson, N. K., O’Brien, T. A., Göttgens, B., et al. (2013) · Blood

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 133

Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells

Leddin, M., Perrod, C., Hoogenkamp, M., Ghani, S., Assi, S., Heinz, S., Wilson, N. K., Follows, G., Schönheit, J., Vockentanz, L., et al. (2011) · Blood

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 131

Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis

Dong, F., Hao, S., Zhang, S., Zhu, C., Cheng, H., Yang, Z., Hamey, F. K., Wang, X., Gao, A., Wang, F., et al. (2020) · Nature Cell Biology

Hematopoietic Stem Cell TransplantationSingle-cell and spatial transcriptomics

Cited by 121

The transcription factor ERG regulates super-enhancers associated with an endothelial-specific gene expression program

Kalna, V., Yang, Y., Peghaire, C. R., Frudd, K., Hannah, R., Shah, A. V., Osuna Almagro, L., Boyle, J. J., Göttgens, B., Ferrer, J., et al. (2019) · Circulation Research

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 119