Cited by 291Metabolism, Diabetes, and CancerLiver Disease Diagnosis and TreatmentMetabolism and Genetic Disorders

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

Open access

Zhang, Dongyan, Liu, Zhen-Xiang, Choi, Cheol Soo, Tian, Liqun, Kibbey, Richard, Dong, Jianying, Cline, Gary W., Wood, Philip A., Shulman, Gerald I.·2007·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0707060104PMC PMC2040460

Open this paper in CoChat — free account

Abstract

Alterations in mitochondrial function have been implicated in the pathogenesis of insulin resistance and type 2 diabetes. However, it is unclear whether the reduced mitochondrial function is a primary or acquired defect in this process. To determine whether primary defects in mitochondrial β-oxidation can cause insulin resistance, we studied mice with a deficiency of long-chain acyl-CoA dehydrogenase (LCAD), a key enzyme in mitochondrial fatty acid oxidation. Here, we show that LCAD knockout mice develop hepatic steatosis, which is associated with hepatic insulin resistance, as reflected by reduced insulin suppression of hepatic glucose production during a hyperinsulinemic-euglycemic clamp. The defects in insulin action were associated with an ≈40% reduction in insulin-stimulated insulin receptor substrate-2-associated phosphatidylinositol 3-kinase activity and an ≈50% decrease in Akt2 activation. These changes were associated with increased PKCε activity and an aberrant 4-fold increase in diacylglycerol content after insulin stimulation. The increase in diacylglycerol concentration was found to be caused by de novo synthesis of diacylglycerol from medium-chain acyl-CoA after insulin stimulation. These data demonstrate that primary defects in mitochondrial fatty acid oxidation capacity can lead to diacylglycerol accumulation, PKCε activation, and hepatic insulin resistance.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.0707060104

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824
Cellular mechanisms of insulin resistance
Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714
Self-citation
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193
Self-citation
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107
Self-citation
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952
Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle
Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561
Self-citation
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
Samuel, V. T., Liu, Z.-X., Qu, X., Elder, B. D., Bilz, S., Befroy, D., Romanelli, A. J., & Shulman, G. I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313478200 · Cited by 1,322
Self-citation
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232

Flagged first, then by citations

Show all 27 references

Sorted by citations

Items 201–290 of 290

Novel ACADVL variants resulting in mitochondrial defects in long-chain acyl-CoA dehydrogenase deficiency
Chen, T., Tong, F., Wu, X., Zhu, L., Yi, Q., Zheng, J., Yang, R., Zhao, Z., Cang, X., Shu, Q., et al. (2020) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2000339 · Cited by 10
Reception and intracellul ar mechanisms of insulin action (part 2)
Tronko, M. D., Ковзун, О. І., PUSHKAREV, V. V., SOKOLOVA, L. K., & Pushkarev, V. M. (2018) · Endokrynologia · doi:10.31793/1680-1466.2018.23-4.341 · Cited by 10
Bioinformatics reveals diagnostic potential of cuproptosis-related genes in the pathogenesis of sepsis
Sun, Z., Zhao, Q., Zhang, J., Hu, Y., Qu, J., Gao, H., & Peng, Z. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22664 · Cited by 9
Adipose Tissue Inflammation and Insulin Resistance
Francisco, L., Miriam, H., de Oliveira, A. C., & Alonso‐Vale, M. I. C. (2012) · InTech eBooks · doi:10.5772/53974 · Cited by 9
Recombinant adeno‐associated virus‐mediated gene delivery of long chain acyl coenzyme A dehydrogenase (LCAD) into LCAD‐deficient mice
Beattie, S. G., Goetzman, E. S., Tang, Q., Conlon, T. J., Campbell‐Thompson, M., Matern, D., Vockley, J. E., & Flotte, T. R. (2008) · The Journal of Gene Medicine · doi:10.1002/jgm.1242 · Cited by 9
Structural basis for expanded substrate specificities of human long chain acyl-CoA dehydrogenase and related acyl-CoA dehydrogenases
Narayanan, B., Xia, C., McAndrew, R. P., Shen, A. L., & Kim, J. J. (2024) · Scientific Reports · doi:10.1038/s41598-024-63027-6 · Cited by 8
Identification of differentially expressed genes in the livers of chronically i-As-treated hamsters
Hernández, A., Sampayo‐Reyes, A., & Marcos, R. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.05.013 · Cited by 8
Identification of molecular markers for superior quantitative traits in a novel sea cucumber strain by comparative microRNA-mRNA expression profiling
Chen, Y., Li, Y., Zhan, Y., Hu, W., Sun, J., Zhang, W., Song, J., Li, D., & Chang, Y. (2020) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2020.100686 · Cited by 8
RETRACTED: ACADL Functions as a Tumor Suppressor in Hepatocellular Carcinoma Metastasis by Inhibiting Matrix Metalloproteinase 14
Guo, D., Zhang, X., Cui, H., Yu, D., Zhang, H., Shi, X., Pang, C., Li, J., Guo, W., & Zhang, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.821484 · Cited by 8
Retracted
ACADL Promotes the Differentiation of Goat Intramuscular Adipocytes
Li, A., Li, Y., Wang, Y., Wang, Y., Li, X., Qubi, W., Xiong, Y., Zhu, J., Liu, W., & Lin, Y. (2023) · Animals · doi:10.3390/ani13020281 · Cited by 8
Construction of a fatty acid metabolism-related gene signature for predicting prognosis and immune response in breast cancer
Li, Q., Liu, Y., Lu, S., Yang, J., Miao, H., He, X., Huang, H., & Zhang, J. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1002157 · Cited by 8
Cellular and molecular effects of Baccharis dracunculifolia D.C. and Plectranthus barbatus Andrews medicinal plant extracts on retinoid metabolism in the human hepatic stellate cell LX-2
da Silva, C. M., Caetano, F. H., Pereira, F. D. C., Marin‐Morales, M. A., Sakane, K. K., & Moraes, K. C. M. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2591-8 · Cited by 8
Polyphenols and Exercise in Mitochondrial Biogenesis: Focus on Age-Related CNS Disorders
Tu, J. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05121-y · Cited by 11
Polystyrene microplastics modulation of hexavalent chromium toxicity in quails: transcriptomic and toxicological insights
Liu, D., Song, K., Li, M., Han, B., Lv, Z., Li, J., Li, S., Lu, J., Ji, S., Ma, J., et al. (2025) · Environmental Chemistry and Ecotoxicology · doi:10.1016/j.enceco.2025.12.021 · Cited by 7
Fas‐Associated Factor 1 Promotes Hepatic Insulin Resistance via JNK Signaling Pathway
Sun, B., Zhou, J., Gao, Y., He, F., Xu, H., Chen, X., Zhang, W., & Chen, L. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3756925 · Cited by 7
Research progress on ncRNAs regulation of mitochondrial dynamics in diabetes
Wu, Y., Lan, H., Zhang, D., Hu, Z., Zhang, J., Li, Z., Xia, P., Tang, X., Cai, X., & Yu, P. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30878 · Cited by 7
Self-citation
The role of lipid droplet associated proteins in inherited human disorders
Duan, X., & Savage, D. B. (2023) · FEBS Letters · doi:10.1002/1873-3468.14779 · Cited by 7
Do mitochondria care about insulin resistance?
Koliaki, C. C., & Roden, M. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.04.004 · Cited by 7
Normal rates of whole‐body fat oxidation and gluconeogenesis after overnight fasting and moderate‐intensity exercise in patients with medium‐chain acyl‐CoA dehydrogenase deficiency
Huidekoper, H. H., Ackermans, M. T., Koopman, R., van Loon, L. J. C., Sauerwein, H. P., & Wijburg, F. A. (2012) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-012-9532-8 · Cited by 7
Acadl-SNP based genotyping assay for long-chain acyl-CoA dehydrogenase deficient mice
Luther, R. J., Almodovar, A. J. O., Fullerton, R., & Wood, P. A. (2012) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2012.02.009 · Cited by 7
Self-citation
Proteomic Analysis of 3T3-L1 Adipocytes Treated with Insulin and TNF-α
Chan, H., Bhide, K. P., Vaidyam, A. N., Hedrick, V., Sobreira, T. J. P., Sors, T. G., Grant, R. W., & Aryal, U. K. (2019) · Proteomes · doi:10.3390/proteomes7040035 · Cited by 7
Disrupted metabolic flux balance between pyruvate dehydrogenase and pyruvate carboxylase in human fatty liver
Park, J. M., Lin, S., Baxter, J. D., Harrison, C. E., Leary, J., Mozingo, C., Liticker, J., Malloy, C. R., & Jin, E. S. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156151 · Cited by 6
Dietary formaldehyde: a silent aggravator of diabetes and cognitive impairments
Xu, H., Chen, H., Li, Y., Luo, T., Zhao, D., Chen, X., Zhang, H., Hu, X., Xu, H., Wang, Y., et al. (2025) · Nutrition and Diabetes · doi:10.1038/s41387-025-00390-x · Cited by 8
Effect of ACADL on the differentiation of goat subcutaneous adipocyte
Li, A., Li, Y., Qubi, W., Li, X., Zhang, H., Wang, Y., Wang, Y., Zhu, J., & Lin, Y. Q. (2023) · Animal Bioscience · doi:10.5713/ab.22.0308 · Cited by 6
A review of fatty acid oxidation disorder mouse models
Babcock, S. J., Houten, S. M., & Gillingham, M. B. (2024) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2024.108351 · Cited by 6
A Nutrigenomic Framework to Identify Time-Resolving Responses of Hepatic Genes in Diet-Induced Obese Mice
Heo, H., Kim, E., Jeon, S.-M., Kwon, E., Shin, S., Paik, H., Hur, C., & Choi, M. (2013) · Molecules and Cells · doi:10.1007/s10059-013-2336-3 · Cited by 6
The effects of E23K polymorphism in Kir6.2 subunit on insulin sensitivity in skeletal muscle cells by long-chain fatty acyl CoA
Wan, J., Jiang, X., Bai, J., She, Z., & Wang, T. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.02.070 · Cited by 6
Cellular Interactions in the Human Fatty Liver
Sovaila, S., Silvia Sovaila, 2. P. R. S., Purcărea, A., Gheonea, D. I., Ionescu, S. O., & Ciurea, T. (2019) · Journal of Medicine and Life · doi:10.25122/jml-2019-1010 · Cited by 6
Roles of calcium and Mitochondria-Associated Membranes in the development of obesity and diabetes
Cárdenas-Pérez, R. E., & Camacho, A. (2016) · Medicina Universitaria · doi:10.1016/j.rmu.2015.10.004 · Cited by 9
Transcriptomic analysis identifies the shared diagnostic biomarkers and immune relationship between Atherosclerosis and abdominal aortic aneurysm based on fatty acid metabolism gene set
Gu, X., Yu, Z., Qian, T., Jin, Y., Xu, G., Li, J., Gu, J., Li, M., & Tao, K. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1365447 · Cited by 5
β-Resorcylic acid prevents MASLD in ob/ob mice by modulating lipid metabolism and inflammation in the liver
López-Herrador, S., Torres‐Rusillo, S., González‐García, P., Jiménez-Sánchez, L., Corral-Sarasa, J., Bakkali, M., Díaz-Casado, M. E., & López, L. C. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107906 · Cited by 3
Preclinical research of dihydromyricetin for fibrotic diseases
Wang, X., Mai, P., Yuan, Z.-H., & Qiu, Z. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1691796 · Cited by 3
Redox proteomic investigation of tetracycline‐induced steatosis
Madian, A. G. (2014) · PROTEOMICS · doi:10.1002/pmic.201400554 · Cited by 3
Insulin and the Physiology of Carbohydrate Metabolism
Pereira, S., & Giacca, A. (2011) · Energy balance and cancer · doi:10.1007/978-1-4419-9911-5_1 · Cited by 3
A liquid chromatography tandem mass spectrometry method for a semiquantitative screening of cellular acyl-CoA
Pearce, R. W., Kodger, J. V., & Sandlers, Y. I. (2021) · Analytical Biochemistry · doi:10.1016/j.ab.2021.114430 · Cited by 3
Obesity and the Pathogenesis of Nonalcoholic Fatty Liver Disease
Fabbrini, E., & Magkos, F. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1203-2_9 · Cited by 3
Mitochondrial Dysfunction in Insulin Insensitivity and Type 2 Diabetes and New Insights for Their Prevention and Management
Wang, C., Chi, K.-T., & Wei, Y. (2012) · InTech eBooks · doi:10.5772/52320 · Cited by 2
Pathogenesis of Hepatic Steatosis and Fibrosis: Role of Leptin
Magkos, F., Fabbrini, E., & Klein, S. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_8 · Cited by 2
Combined analysis of whole-exome sequencing and RNA sequencing in type 2 diabetes mellitus patients with thirst and fatigue
Lv, B., Yang, X., An, T., Wu, Y., He, Z., Li, B., Wang, Y., Tan, F., Wang, T., Zhu, J., et al. (2022) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-022-00884-z · Cited by 2
Very long-chain acyl-CoA dehydrogenase deficiency and type I diabetes mellitus: Case report and management challenges
Al-Busaidi, S., Nou'mani, J. A. A., Falahi, Z. A., Al-Farsi, R., Kumar, S., Murshedi, F. A., Awlad‐Thani, K., Nabhani, A. A., & Alawi, A. M. A. (2023) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2023.03.005 · Cited by 2
Labeled breath tests in patients with NASH: Octanoate oxidation relates best to measures of glucose metabolism
Mucinski, J. M., Perry, A. M., Fordham, T. M., Diaz‐Arias, A. A., Ibdah, J. A., Rector, R. S., & Parks, E. J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1172675 · Cited by 2
Treatment with a polyherbal extract improves fat metabolism, attenuates hepatic stellate cell activation and fibrogenesisPreprint
Pavan, K. B., Baig, M. R., Murthy, M. O., Azeemuddin, M. M., Hariprasad, V. R., Rafiq, M., & Rao, R. P. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.06.455195 · Cited by 2
In Utero Protein Deficiency Leads to Impaired Hepatic Lipid Metabolism in Adult Male Rats
Vidyadharan, V. A., Yallampalli, C., & Blesson, C. S. (2026) · Journal of Nutrition · doi:10.1016/j.tjnut.2026.101405 · Cited by 1
SIRT3-mediated mitochondrial fatty acid oxidation protects against hepatic lipid deposition in fatty liver hemorrhagic syndrome
Cao, P., Chen, J., Zeng, C., Hu, Y., Jianyun, Y., Guo, X., Cao, H., Zhang, C., Zhuang, Y., & Hu, G. (2026) · Poultry Science · doi:10.1016/j.psj.2026.106901 · Cited by 1
Stealthy progression of type 2 diabetes mellitus due to impaired ketone production in an adult patient with multiple acyl-CoA dehydrogenase deficiency
Ikeda, N., Wada, Y., Izumi, T., Munakata, Y., Katagiri, H., & Kure, S. (2024) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2024.101061 · Cited by 1
Sphingolipid Metabolism and Insulin Resistance in Dairy Cattle
Navarrete, J. E. R. (2016) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.7238 · Cited by 1
Insulin Resistance
Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2009) · Wiley eBooks · doi:10.1002/9780470747919.ch31 · Cited by 1
Self-citation
Efeitos do deidroepiandrosterona (DHEA) sobre a função vascular e a resistência periférica à insulina em um modelo experimental de menopausa.
Camporez, J. P. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2012.tde-25072012-111253
Postprandial dysmetabolism and cell-derived microparticles as cardiovascular risk factors in metabolic syndrome and type 2 diabetes mellitus
Tushuizen, M. E. (2012) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)
Gastrointestinal Physiology in Obesity
Miras, A. D., & le Roux, C. W. (2012) · doi:10.1002/9781119962083.ch3
PHYTOMEDICINES FOR FATTY LIVER DISEASE AND FUNCTIONAL GASTROINTESTINAL CONDITIONS
Li, G. Q., Kim, M.-S., Jin, F., & Cho, J. (2015) · Wiley eBooks · doi:10.1002/9781119006039.ch17
THE ROLE OF LONG-CHAIN ACYL-COENZYME A SYNTHETASE 1 (ACSL-1) IN LIPID METABOLISM IN HUMAN SKELETAL MUSCLE PRIMARY MYOTUBES.
Ellis, R. J. (2011) · The Scholarship East Carolina University's Institutional Repository (East Carolina University)
Efeitos da suplementação com óleo de peixe sobre a resistência à insulina e a função mitocondrial no músculo esquelético de camundongos alimentados com dieta hiperlipídica.
Martins, A. R. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.87.2014.tde-05012015-152951
Metabolic Pathways of Type 2 Diabetes Intersection of Genetics, Transcriptomics, and Metabolite Profiling
Ferrara, C. T. (2008) · DukeSpace (Duke University)
O desregulador endócrino, dibutilestanho, é um antagonista de PPAR-alfa em ensaios de gene repórter
Prakasan, D. (2015) · RIUnB Institutional Repository (University of Brasília) · doi:10.26512/2015.12.t.20247
Protein kinase STK25 is a regulator of hepatic lipid partitioning and whole body metabolism
Amrutkar, M. (2016) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Efeitos da suplementação com óleo de peixe sobre a resistência à insulina e a função mitocondrial no músculo esquelético de camundongos alimentados com dieta hiperlipídica
Paulo, S., & Hirabara, M. (2014)
Transcriptional Regulation of Mitochondrial Biogenesis and Quality Control
Suliman, H. B., & Piantadosi, C. A. (2015) · Oxidative stress and disease · doi:10.1201/b19420-6
Effects of LXRα phosphorylation on the regulation of lipid metabolism and hepatic fibrosis
Bécares, N. (2017) · UCL Discovery (University College London)
Heat Shock Protein 72 Regulation of Metabolism
Archer, A. E. (2018) · KU ScholarWorks (The University of Kansas)
Tissue Specific Roles of Fatty Acid Oxidation
Lee, J. (2016)
Desnutrição proteica impede os efeitos da taurina sobre o mecanismo de secreção e ação da insulina em camundongos obesos
Branco, R. C. S. (2016) · doi:10.47749/t/unicamp.2016.978949
Papel da transidrogenase de nucleotídeo de nicotinamida mitocondrial (NNT) no metabolismo glicídico e no metabolismo lipídico
Rovani, J. C. (2018) · doi:10.47749/t/unicamp.2018.1064112
Sphingolipid Metabolism and Insulin Resistance in Dairy Cattle
Navarrete, J. E. R. (2016) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.7335
Lifestyle treatment in the regression of NASH: insulin resistance, lipid synthesis, and methodological innovation
Mucinski, J. M. (2022) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/93980
Effects of Trans Fats in Human Macrophages
Zacherl, J. R. (2014) · D-Scholarship@Pitt (University of Pittsburgh)
Additional file 1 of Combined analysis of whole-exome sequencing and RNA sequencing in type 2 diabetes mellitus patients with thirst and fatigue
Lv, B., Yang, X., An, T., Wu, Y., He, Z., Li, B., Wang, Y., Tan, F., Wang, T., Zhu, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20454628
The impact of apple cider vinegar on nonalcoholic fatty liver disease in rainbow trout, Oncorhynchus mykiss: A study of therapeutic potential and health benefits
Asadi, S., Motlagh, H. A., Safari, O., & Javadmanesh, A. (2024) · Journal of the World Aquaculture Society · doi:10.1111/jwas.13106
Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), An Underappreciated Threat.
Buzaid, N. O., & Lawgaly, S. A. (2025) · Benghazi University Medical Journal · doi:10.37376/benunivmedj.v1i1.7364
Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), An Underappreciated Threat.
Buzaid, N. O., & Lawgaly, S. A. (2025) · Benghazi University Medical Journal · doi:10.37376/benunivmedj.v2i1.7364
Papel de las lipasas metabólicas y la lipotoxicidad en el desarrollo de esteatosis hepática y esteatohepatitis no alcohólica
Berlanga, A., Guiu‐Jurado, E., Porras, J. A., Aragonès, G., & Auguet, T. (2015) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2015.03.003 · Cited by 1
Additional file 4 of Combined transcriptome and metabolome analysis reveal key regulatory genes and pathways of feed conversion efficiency of oriental river prawn Macrobrachium nipponense
Ling, F., Fan, Y., Wang, Z., Xie, N., Li, J., Wang, G., & Jianbin, F. (2023) · Figshare · doi:10.6084/m9.figshare.22978054
Additional file 6 of Combined transcriptome and metabolome analysis reveal key regulatory genes and pathways of feed conversion efficiency of oriental river prawn Macrobrachium nipponense
Ling, F., Fan, Y., Wang, Z., Xie, N., Li, J., Wang, G., & Jianbin, F. (2023) · Figshare · doi:10.6084/m9.figshare.22978060
Additional file 5 of Combined transcriptome and metabolome analysis reveal key regulatory genes and pathways of feed conversion efficiency of oriental river prawn Macrobrachium nipponense
Ling, F., Fan, Y., Wang, Z., Xie, N., Li, J., Wang, G., & Jianbin, F. (2023) · Figshare · doi:10.6084/m9.figshare.22978057
Additional file 7 of Combined transcriptome and metabolome analysis reveal key regulatory genes and pathways of feed conversion efficiency of oriental river prawn Macrobrachium nipponense
Ling, F., Fan, Y., Wang, Z., Xie, N., Li, J., Wang, G., & Jianbin, F. (2023) · Figshare · doi:10.6084/m9.figshare.22978063
Additional file 1 of Combined transcriptome and metabolome analysis reveal key regulatory genes and pathways of feed conversion efficiency of oriental river prawn Macrobrachium nipponense
Ling, F., Fan, Y., Wang, Z., Xie, N., Li, J., Wang, G., & Jianbin, F. (2023) · Figshare · doi:10.6084/m9.figshare.22978045
Additional file 3 of Combined transcriptome and metabolome analysis reveal key regulatory genes and pathways of feed conversion efficiency of oriental river prawn Macrobrachium nipponense
Ling, F., Fan, Y., Wang, Z., Xie, N., Li, J., Wang, G., & Jianbin, F. (2023) · Figshare · doi:10.6084/m9.figshare.22978051
Additional file 2 of Combined transcriptome and metabolome analysis reveal key regulatory genes and pathways of feed conversion efficiency of oriental river prawn Macrobrachium nipponense
Ling, F., Fan, Y., Wang, Z., Xie, N., Li, J., Wang, G., & Jianbin, F. (2023) · Figshare · doi:10.6084/m9.figshare.22978048
Restoration of Interaction Between Fatty Acid Oxidation and Electron Transport Chain Proteins In Vitro by Addition of Recombinant VLCAD
Wang, Y., Varga, G. J., Wang, M., Palmfeldt, J., Basu, S., Koppes, E., Jeffrey, A., Hannan, R. J., Sykuta, G., & Vockley, J. (2026) · Biomedicines · doi:10.3390/biomedicines14010222
Les mécanismes de réponse à l'inflammation chronique dans le foie stéatosique et les conséquences sur l'homéostasie cellulaire et la cancérogénèse
Esposti, D. D. (2011) · theses.fr (ABES) · doi:10.70675/b2a8993cz0743z4be8z979cz0a5a932b5326
Influence des polyphénols du raisin rouge sur le stress oxydant chez l'homme sain à risque métabolique : relation avec les mécanismes de l’insulinorésistance
Hokayem, M. (2013) · theses.fr (ABES) · doi:10.70675/8c701197ze5fdz40abza335zf347183fcc44
Implication of mitochondria endoplasmic-reticulum interactions in the control of hepatic metabolism
Theurey, P. (2015) · theses.fr (ABES) · doi:10.70675/c827066dz5c76z4f0azb465z409dc90bb0e5
Mécanisme de l'insulino-résistance lors de la modulation in vivo et in vitro par l'acide nicotinique et les polyphénols
Blond, E. (2012) · theses.fr (ABES) · doi:10.70675/189ac795z9e7az4eb1z9b88z991750b0b668
Rôle dimorphique du récepteur nucléaire CAR dans la régulation de l'homéostasie énergétique et des perturbations métaboliques induites par un mélange de pesticides
Lukowicz, C. (2018) · theses.fr (ABES) · doi:10.70675/881e84fazadd6z4a73zafdfzcf838fd002b4
Rôle des points de contact Réticulum Endoplasmique-Mitochondrie (MAMs) dans la régulation du métabolisme glucido-lipidique du foie et importance du Monoxyde d’Azote (NO)
Bassot, A. (2019) · theses.fr (ABES) · doi:10.70675/bf11117az778az470az8feczf040df41bbd1
Homéostasie des céramides et hépatopathies métaboliques
Régnier, M. (2018) · theses.fr (ABES) · doi:10.70675/2fb92711z373cz4b27z8082z7aa3f8930e63
Influence du sexe dans la susceptibilité aux hépatopathies métaboliques
Smati, S. (2019) · theses.fr (ABES) · doi:10.70675/01997f55za990z41e6z96baz8221de2a6281
Impact de l'obésité sur la toxicologie des contaminants alimentaires : l'exemple de la Fumonisine B1
Dopavogui, L. (2022) · theses.fr (ABES) · doi:10.70675/8fcfcad7z134cz4df2zade9z155636aa8994
GFPT2 promotes macrophage dysfunction in atherosclerosis via ACADL glycosylation-dependent suppression of ACADL and Arg1
Ke, K., Yan, L., Chen, R., Zhang, C., Yang, W., Zhang, Z., & Lin, J. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06203-3
Dioscin attenuates aniline-induced liver injury by targeting the ACOT2-mediated ROS–JAK2/STAT3–CLN5 axis and restoring mitochondrial fatty acid oxidation and lysosomal lipophagy
Xing, Y., Zhang, B., Chen, Y., Wang, H., Yu, S., Chen, L., & Wang, Y. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.10.039

Authors: Zhang, D., Liu, Z.-X., Choi, C. S., Tian, L., Kibbey, R., Dong, J., Cline, G. W., Wood, P. A., & Shulman, G. I.
Affiliations: Howard Hughes Medical Institute (US)
*Howard Hughes Medical Institute and
Departments of †Internal Medicine and
University of Alabama at Birmingham (US)
Corresponding author: Shulman, Gerald I.
ORCID: Zhang, Dongyan
Choi, Cheol Soo
Kibbey, Richard
Cline, Gary W.
Wood, Philip A.
Shulman, Gerald I.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2007-10-23
Volume: 104
Issue: 43
Pages: 17075-17080
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0707060104
PMC: PMC2040460
OpenAlex: W2091450162
Cited by: 291
References: 27
Citations by year: 2026: 5 · 2025: 11 · 2024: 10 · 2023: 22 · 2022: 14 · 2021: 11 · 2020: 9 · 2019: 14 · 2018: 13 · 2017: 19 · 2016: 15 · 2015: 19 · 2014: 25 · 2013: 15 · 2012: 22
FWCI: 6.76
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
U.S. Public Health Service (R01 DK-40936)
National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK40936, U24DK59635, R01DK040936, U24DK059635)
National Center for Research Resources (R01-RR02599, R01RR002599)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Keywords: long-chain acyl-CoA dehydrogenase deficiency, mitochondrial dysfunction, hepatic steatosis, hepatic insulin resistance, mitochondrial fatty acid oxidation, insulin receptor substrate 2, phosphatidylinositol 3-kinase, AKT2, protein kinase C epsilon, diacylglycerol, type 2 diabetes
MeSH terms: Acyl Coenzyme A, Animals, Calorimetry, Carbon Isotopes, Diglycerides, Energy Metabolism, Fatty Liver, Gene Expression Regulation, Glucose, Homeostasis, Insulin, Insulin Resistance, Liver, Mitochondria, Oxidation-Reduction, Triglycerides, Signal Transduction, Muscle, Skeletal, Acyl-CoA Dehydrogenase, Long-Chain, Mice, Protein Kinase C-epsilon

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks