The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1
Open accessAbstract
The cornified layer is a compacted lattice of lipid-embedded corneocytes that provides an organism's barrier to the external environment. Cornification is the final differentiative step for epidermal keratinocytes and involves dramatic cell condensation before death. Using conditional gene deletion in mice, we identified the transcriptional repressor Blimp-1 (B lymphocyte-induced maturation protein-1) as an important regulator of keratinocyte transition from the granular to the cornified layer. More than 250 genes are misregulated in conditional knockout epidermis, including those encoding transcription factors, signal transduction components, proteinases, and enzymes involved in lipid metabolism. Steady-state mRNA and ChIP analyses of a subset of these genes provide evidence that nfat5 , fos , prdm1 , and dusp16 are novel direct targets of Blimp-1. Identifying nfat5 as a target of Blimp-1 repression indicates that cornification involves suppression of normal osmotic regulation in granular cells. Consistently, conditional knockout mice have delayed barrier formation as embryos, enlarged granular layer cells and corneocytes, and a morphologically abnormal cornified layer. These studies provide insight into cornification, identifying transcriptional regulatory circuitry and indicating the importance of blocking osmotic homeostasis.
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“Alternatively, it has recently been suggested that Blimp1 functions in terminally differentiated sebocytes8 as well as in granular IFE cells9, 10.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [10]
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“Subsequently, it was described that terminally differentiated sebocytes8, as well as granular layer IFE keratinocytes9, 10 are marked by the Blimp1 protein.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [10]
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Items 101–152 of 152
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“In the skin, Blimp1 maintains tissue homeostasis and epithelial barrier function (Kretzschmar et al., 2014; Magnusdottir et al., 2007).”
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“Prdm1 governs germ cell specification [23–25] and regulates development of the sebaceous gland [26], skin epidermis [27], the posterior forelimb, caudal pharyngeal arches, sensory vibrissae, heart [28], photoreceptor [29], and intestine [30, 31].”
BackgroundForkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation
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“Blimp-1 knockout in keratinocytes resulted in a sequela termed by the investigators as ‘‘a cyst-like structure that proved to be filled with lipid’’ in the skin of adult mice (Magnusdottir et al., 2007).”
BackgroundBlimp-1 Connects the Intrinsic and Extrinsic Regulation of T Cell Homeostasis
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“Blimp-1 is also crucial for germ cell [24], skin [25], and sebaceous gland [26] development in the mouse and limb bud and muscle formation in zebrafish [27, 28], indicating an important role for Blimp-1 outside the hematopoietic system.”
BackgroundExpression patterns of prdm1 during chicken embryonic and germline development
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“2006) and is also an important regulator of epidermal terminal differentiation in mice (Magnusdottir et al. 2007).”
BackgroundInfluentialBlimp1: Driving Terminal Differentiation to a T
Xin, A., Nutt, S. L., Belz, G. T., & Kallies, A. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-5632-3_8 · Cited by 14
“expression [ 19 , 30, 114] and to restrict cell survival [14].”
BackgroundGlucose modulates IRF6 transcription factor dimerization to enable epidermal differentiation
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“Furthermore, expression of the transcription factor Blimp1, marking a subset of cells in the granular layer (Magnúsdóttir et al., 2007), was also reduced in K5-Ets1 BT skin (Fig.”
BackgroundManti, P. G., Darbellay, F., Leleu, M., Coughlan, A. Y., Moret, B., Cuennet, J. G., Droux, F., Stoudmann, M., Mancini, G., Hautier, A., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10102647 · Cited by 10
“Prdm1 (also known as Blimp1) is a zinc-finger transcriptional repressor [11] that was shown to be a master regulator controlling terminal differentiation of B-lymphocytes [12–14]; it also governs T-cell homeostasis [15] and primordial germ cell specification [16], stem cell maintenance in the sebaceous gland [17], and…”
BackgroundChang, H., Huang, D.-Y., Wu, N., Kannagi, R., Wang, L., & Lin, W. (2018) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2018.08.011 · Cited by 9
da Costa, L. C. O., Gardinassi, L. G., Veras, F. P., Milanezi, C., Ramalho, L. N. Z., Benevides, L., Alves-Filho, J. C., Silva, J. S., & Souza, C. D. S. (2022) · Archives of Dermatological Research · doi:10.1007/s00403-022-02379-3 · Cited by 8
“1 3 in the epidermis of CKO mice included the direct targets of Blimp-1 repression, those that require Blimp-1 for their expression in the epidermis, and genes encoding transcription factors, signal transduction components, proteinases, and enzymes involved in lipid metabolism [32].”
BackgroundWang, A. Y. L., Aviña, A. E., Liu, Y., Chang, Y., & Kao, H. (2025) · Antioxidants · doi:10.3390/antiox14020183 · Cited by 7
“Blimp-1 plays an integral role in terminal differentiation in epithelial tissues, and it is necessary for proper organ formation, such as the mammary glands and sebaceous glands [51].”
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Calame, K. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1090044 · Cited by 7
“Expression in adult tissues outside of the lymphoid lineages led to the understanding that Blimp-1 plays an important role in the terminal differentiation of epidermal keratinocytes (28) and epidermal sebocytes (29).”
BackgroundSelf-citationOne PRDM is not enough for germ cell development
Bikoff, E. K., & Robertson, E. J. (2008) · Nature Genetics · doi:10.1038/ng0808-934 · Cited by 6
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Downregulation of Blimp1 inhibits the maturation of bone marrow-derived dendritic cells
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“In addition, Blimp1 modulates lipopolysaccharide (LPS)‑induced differentiation of primary B lymphocytes (7), induces the differentiation of macrophages (8) and affects the maturation of DCs by regulating various signaling cascades (9).”
The BLIMP1—EZH2 nexus in a non-Hodgkin lymphoma
Anderson, K. J., Ósvaldsdóttir, Á. B., Atzinger, B., Traustadóttir, G. Á., Jensen, K. N., Lárusdóttir, A. E., Bergþorsson, J. Þ., Harðardóttir, I., & Magnúsdóttir, E. (2020) · Oncogene · doi:10.1038/s41388-020-1347-8 · Cited by 5
“Transcription factor ChIP for BLIMP1 and EZH2 was performed as previously described [32, 78, 79].”
MethodSelf-citationGlucose modulates transcription factor dimerization to enable tissue differentiationPreprint
Lopez-Pajares, V., Bhaduri, A., Zhao, Y., Gowrishankar, G., Donohue, L., Guo, M. G., Siprashvili, Z., Miao, W., Nguyen, D. T., Li, A. M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.28.518222 · Cited by 5
Disease-linked regulatory DNA variants and homeostatic transcription factors in epidermis
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NFAT5 Controls the Integrity of Epidermis
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Organoid Modeling of Mouse Anterior Tongue Epithelium Reveals Regional and Cellular Identities
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Metadata
- Authors
- Magnúsdóttir, E., Kalachikov, S., Mizukoshi, K., Savitsky, D., Ishida-Yamamoto, A., Panteleyev, A. A., & Calame, K.
- Affiliations
- Columbia University (US)
- Columbia Genome Center, and
- Asahikawa Medical College Hospital (JP)
- Department of Dermatology, Asahikawa Medical College, Asahikawa 078-8510, Japan
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-09-18
- Volume
- 104
- Issue
- 38
- Pages
- 14988-14993
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1986600
- OpenAlex
- W2148705591
- Semantic Scholar
- e4381d4ef6d206ca8953a70f0a5f76ffdfe8846d
- Cited by
- 152
- References
- 36
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 2 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 10 · 2016: 3 · 2015: 9 · 2014: 15 · 2013: 16 · 2012: 8
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI050659, R01 AI43576, R01-AI50659, R01AI043576)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR044535, K01 AR02204, K01AR002204)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Health Sciences › Medicine › Dermatology › Genetic and rare skin diseases.
- Keywords
- Blimp-1, keratinization, keratinocytes, cornified layer, transcriptional repression, conditional knockout mice, NFAT5, FOS, DUSP16, skin barrier, osmotic balance, granular layer, corneocytes, lipid metabolism
- MeSH terms
- Positive Regulatory Domain I-Binding Factor 1, Epidermal Cells, Animals, Cell Differentiation, Embryonic Structures, Epidermis, Humans, Phenotype, Repressor Proteins, RNA, Messenger, Transcription Factors, Keratinocytes, Proto-Oncogene Proteins c-fos, Gene Deletion, Mice, Knockout, Oligonucleotide Array Sequence Analysis, NFATC Transcription Factors, Mice, Dual-Specificity Phosphatases, Mitogen-Activated Protein Kinase Phosphatases
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